Influence of β-cyclodextrin on the Properties of Norfloxacin Form A

Cyclodextrins are able to form host-guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid s...

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Autores principales: Chierentin, Lucas, Garnero, Claudia, Chattah, Ana Karina, Delvadia, Poonam, Karnes, Thomas, Longhi, Marcela Raquel, Salgado, Hérida Regina Nunes
Formato: article
Lenguaje:Inglés
Publicado: 2022
Materias:
Bioassay
Complexation
Intrinsic dissolution
Norfloxacin
β-cyclodextrin
Beta-cyclodextrin
Acceso en línea:https://link.springer.com/article/10.1208/s12249-014-0259-8
http://hdl.handle.net/11086/27914
http://dx.doi.org/10.1208/s12249-014-0259-8
http://dx.doi.org/10.1208/s12249-014-0259-8
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-27914
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Bioassay
Complexation
Intrinsic dissolution
Norfloxacin
β-cyclodextrin
Beta-cyclodextrin
spellingShingle Bioassay
Complexation
Intrinsic dissolution
Norfloxacin
β-cyclodextrin
Beta-cyclodextrin
Chierentin, Lucas
Garnero, Claudia
Chattah, Ana Karina
Delvadia, Poonam
Karnes, Thomas
Longhi, Marcela Raquel
Salgado, Hérida Regina Nunes
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
topic_facet Bioassay
Complexation
Intrinsic dissolution
Norfloxacin
β-cyclodextrin
Beta-cyclodextrin
description Cyclodextrins are able to form host-guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.
format article
author Chierentin, Lucas
Garnero, Claudia
Chattah, Ana Karina
Delvadia, Poonam
Karnes, Thomas
Longhi, Marcela Raquel
Salgado, Hérida Regina Nunes
author_facet Chierentin, Lucas
Garnero, Claudia
Chattah, Ana Karina
Delvadia, Poonam
Karnes, Thomas
Longhi, Marcela Raquel
Salgado, Hérida Regina Nunes
author_sort Chierentin, Lucas
title Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_short Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_full Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_fullStr Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_full_unstemmed Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
title_sort influence of β-cyclodextrin on the properties of norfloxacin form a
publishDate 2022
url https://link.springer.com/article/10.1208/s12249-014-0259-8
http://hdl.handle.net/11086/27914
http://dx.doi.org/10.1208/s12249-014-0259-8
http://dx.doi.org/10.1208/s12249-014-0259-8
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