On stochastic spatial patterns and neuronal polarity

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Polarization refers to asymmetric changes in cellular organization that occur in response to external or internal signals. Although neurons can spontaneously establish and maintain asymmetric distributions of signalling molecules on the plasma membrane, it is not clear how intrinsic noise affects ne...

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Autores principales: Menchón, Silvia Adriana, Wio, Horacio Sergio
Formato: article
Lenguaje:Inglés
Publicado: 2022
Materias:
Modelos estocásticos espaciales
Biofísica
Stochastic spatial patterns
Biophysics
Acceso en línea:http://hdl.handle.net/11086/24805
http://dx.doi.org/10.1140/epjb/e2014-50267-1
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-24805
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Modelos estocásticos espaciales
Biofísica
Stochastic spatial patterns
Biophysics
spellingShingle Modelos estocásticos espaciales
Biofísica
Stochastic spatial patterns
Biophysics
Menchón, Silvia Adriana
Wio, Horacio Sergio
On stochastic spatial patterns and neuronal polarity
topic_facet Modelos estocásticos espaciales
Biofísica
Stochastic spatial patterns
Biophysics
description Polarization refers to asymmetric changes in cellular organization that occur in response to external or internal signals. Although neurons can spontaneously establish and maintain asymmetric distributions of signalling molecules on the plasma membrane, it is not clear how intrinsic noise affects neuronal polarization. In this work we present a stochastic model based on endocytosis, exocytosis and lateral diffusion, to study the effects of low number of molecules, (high noise intensity), on neuronal polarization. Numerical results were obtained by solving the master equation using Gillespie?s algorithm. Our model suggests that the formation of a single pole of molecular asymmetry is very robust to noise; furthermore, in the presence of noise, neuronal polarization could occur even with reduced feedback strength.
format article
author Menchón, Silvia Adriana
Wio, Horacio Sergio
author_facet Menchón, Silvia Adriana
Wio, Horacio Sergio
author_sort Menchón, Silvia Adriana
title On stochastic spatial patterns and neuronal polarity
title_short On stochastic spatial patterns and neuronal polarity
title_full On stochastic spatial patterns and neuronal polarity
title_fullStr On stochastic spatial patterns and neuronal polarity
title_full_unstemmed On stochastic spatial patterns and neuronal polarity
title_sort on stochastic spatial patterns and neuronal polarity
publishDate 2022
url http://hdl.handle.net/11086/24805
http://dx.doi.org/10.1140/epjb/e2014-50267-1
work_keys_str_mv AT menchonsilviaadriana onstochasticspatialpatternsandneuronalpolarity
AT wiohoraciosergio onstochasticspatialpatternsandneuronalpolarity
bdutipo_str Repositorios
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