Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study

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Aims: Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by the type A receptor (EDNRA). This action may play a significant role in the etiology of hypertension. There are different works that shows an association between certain polymorphisms of endothelin axis a...

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Autores principales: Lassen, Oscar, Herrera, Jimena, Dotto, Gladys, Ojeda, Silvia María, Garutti, Alicia, Bertolotto, Patricia Isolina, Tabares, Sandra, Sembaj, Adela
Formato: article
Lenguaje:Inglés
Publicado: 2022
Materias:
Endothelin-1 gene
Endothelin receptor a gene
Genetic variation
Hypertension
Acceso en línea:http://hdl.handle.net/11086/23477
https://doi.org/10.9734/BJMMR/2016/20520
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-23477
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Endothelin-1 gene
Endothelin receptor a gene
Genetic variation
Hypertension
spellingShingle Endothelin-1 gene
Endothelin receptor a gene
Genetic variation
Hypertension
Lassen, Oscar
Herrera, Jimena
Dotto, Gladys
Ojeda, Silvia María
Garutti, Alicia
Bertolotto, Patricia Isolina
Tabares, Sandra
Sembaj, Adela
Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study
topic_facet Endothelin-1 gene
Endothelin receptor a gene
Genetic variation
Hypertension
description Aims: Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by the type A receptor (EDNRA). This action may play a significant role in the etiology of hypertension. There are different works that shows an association between certain polymorphisms of endothelin axis and clinical phenotype of hypertension. We describe the genetic variability +138/ex1 insertion/deletion (I/D) adenosine (A) in the ET-1 gene and polymorphism thymidine/cytosine (T/C) His323His in the EDNRA gene associated at the clinical variability in hypertensive patients. Study Design: Observational, transversal and analytical study. Place and Duration of Study: Hypertension Service at the Internal Medicine Department of Córdoba Hospital, and Biochemical and Molecular Biology Department in School of Medicine, National University of Cordoba, Argentine. Patients considered hypertensive between April 2009 and April 2010. Methodology: Were assessed 136 patients serum lipid profiles, renal and hepatic functions and were taken Thoracic X-rays, electrocardiograms, and echocardiographs. DNA extracted from circulating leukocyte were used to analyze the polymorphisms of genes by PCR-RFLP. Results: For the polymorphisms of Receptor A from Endothelin -1 studied the presence of cytosine homozygous genotype was less frequent in males (P = .02). For both genders, the same genotype was associated to low plasma alkaline phosphatase activity and cholesterol levels. The presence of thymidine nucleotide allele correlated with plasma alkaline phosphatase activity and cholesterol levels. The Thymidine allele correlated with the degree of cardiovascular compromise (r = 0.54, P= .002). For the genetic variant in the ET-1 gene, the homozygous adenine deletion was associated to normal plasma levels of glutamate/pyruvate transaminase enzyme activity, uric acid concentration, cholesterol, and Low Density Lipoprotein in hypertensive subjects without clinical risk. Conclusion: We observed a gender-specific protective effect for EDNRA gene variations, the subjects that carried the TT genotype presented more aggressive symptomatology. These results show an association between plasmatic biochemical parameters, the clinical condition, and polymorphisms in the endothelin axis genes.
format article
author Lassen, Oscar
Herrera, Jimena
Dotto, Gladys
Ojeda, Silvia María
Garutti, Alicia
Bertolotto, Patricia Isolina
Tabares, Sandra
Sembaj, Adela
author_facet Lassen, Oscar
Herrera, Jimena
Dotto, Gladys
Ojeda, Silvia María
Garutti, Alicia
Bertolotto, Patricia Isolina
Tabares, Sandra
Sembaj, Adela
author_sort Lassen, Oscar
title Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study
title_short Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study
title_full Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study
title_fullStr Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study
title_full_unstemmed Plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study
title_sort plasmatic biochemical variables associated with polymorphisms in the endothelin-1 and endothelin-1 receptor a genes in hypertensive patients : pilot study
publishDate 2022
url http://hdl.handle.net/11086/23477
https://doi.org/10.9734/BJMMR/2016/20520
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