Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma

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The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present...

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Autores principales:	Morelatto, Rosana, Itoiz, María-Elina, Guiñazu, Natalia, Piccini, Daniel, Gea, Susana, López de Blanc, Silvia
Formato:	article
Lenguaje:	Inglés
Publicado:	Acta Odontológica Latinoamericana 2020
Materias:	Field cancerization Oral squamous cell carcinoma Nitric Oxide Synthase 2 (NOS2) Malignity markers Cancerización de campo Carcinoma oral de células escamosas Marcadores de malignidad
Acceso en línea:	http://dx.doi.org/doi:10.4317/medoral.19351 http://hdl.handle.net/11086/15649
Aporte de:	Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba

id	I10-R141-11086-15649
record_format	dspace
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-141
collection	Repositorio Digital Universitario (UNC)
language	Inglés
topic	Field cancerization Oral squamous cell carcinoma Nitric Oxide Synthase 2 (NOS2) Malignity markers Cancerización de campo Carcinoma oral de células escamosas Marcadores de malignidad
spellingShingle	Field cancerization Oral squamous cell carcinoma Nitric Oxide Synthase 2 (NOS2) Malignity markers Cancerización de campo Carcinoma oral de células escamosas Marcadores de malignidad Morelatto, Rosana Itoiz, María-Elina Guiñazu, Natalia Piccini, Daniel Gea, Susana López de Blanc, Silvia Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
topic_facet	Field cancerization Oral squamous cell carcinoma Nitric Oxide Synthase 2 (NOS2) Malignity markers Cancerización de campo Carcinoma oral de células escamosas Marcadores de malignidad
description	The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.
format	article
author	Morelatto, Rosana Itoiz, María-Elina Guiñazu, Natalia Piccini, Daniel Gea, Susana López de Blanc, Silvia
author_facet	Morelatto, Rosana Itoiz, María-Elina Guiñazu, Natalia Piccini, Daniel Gea, Susana López de Blanc, Silvia
author_sort	Morelatto, Rosana
title	Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_short	Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_full	Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_fullStr	Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_full_unstemmed	Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_sort	nitric oxide synthase 2 (nos2) expression in histologically normal margins of oral squamous cell carcinoma
publisher	Acta Odontológica Latinoamericana
publishDate	2020
url	http://dx.doi.org/doi:10.4317/medoral.19351 http://hdl.handle.net/11086/15649
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bdutipo_str	Repositorios
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Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma

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