EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION

<div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 127.333px; transform: scale(1.01035, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.0640176448823">Previous studies indicate a...

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Autor principal: Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L.
Formato: article
Lenguaje:Inglés
Publicado: 2019
Materias:
sex chromosome; fore core genotype mouse model; sex differences; sodium appetite
Acceso en línea:http://hdl.handle.net/11086/13466
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-13466
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic sex chromosome; fore core genotype mouse model; sex differences; sodium appetite
spellingShingle sex chromosome; fore core genotype mouse model; sex differences; sodium appetite
Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L.
EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION
topic_facet sex chromosome; fore core genotype mouse model; sex differences; sodium appetite
format article
author Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L.
author_facet Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L.
author_sort Dadam, F.; Caeiro, X.; Cisternas, C.D.; Macchione, A.F.; Cambiasso, M.J.; Vivas, L.
title EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION
title_short EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION
title_full EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION
title_fullStr EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION
title_full_unstemmed EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS-IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION
title_sort effect of sex chromosome complement on sodium appetite and fos-immunoreactivity induced by sodium depletion
publishDate 2019
url http://hdl.handle.net/11086/13466
work_keys_str_mv AT dadamfcaeiroxcisternascdmacchioneafcambiassomjvivasl effectofsexchromosomecomplementonsodiumappetiteandfosimmunoreactivityinducedbysodiumdepletion
bdutipo_str Repositorios
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description <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 127.333px; transform: scale(1.01035, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.0640176448823">Previous studies indicate a sex chromosome complement (SCC) effect on the Angiotensin</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 194.8px; transform: scale(0.947701, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.3133509856461">II-sexually dimorphic hypertensive and bradycardic baroreflex responses. We sought to evaluate whether SCC may differentially modulate sexually dimorphic induced sodium</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 228.533px; transform: scale(1.01391, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.122684313297">appetite and specific brain activity due to physiological stimulation of the rennin angiotensin</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 164.133px; top: 262.267px; transform: scale(1.03821, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="541.948016151309">system. For this purpose, we used the "four core genotypes" mouse model, in which the</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 296px; transform: scale(1.02057, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="591.9320176409481">effect of gonadal sex and SCC is dissociated, allowing comparisons of sexually dimorphic</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 329.733px; transform: scale(1.03147, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.0640176448823">traits between XX and XY females as well as in XX and XY males. Gonadectomized mice</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 363.467px; transform: scale(1.05091, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="542.2706828275919">were sodium depleted by furosemide (50 mg/kg) and low sodium diet treatment;</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 397.2px; transform: scale(1.02997, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="516.0173487118483"> control groups were administered the vehicle and maintained on normal sodium diet. </div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 219.067px; top: 532.133px; transform: scale(1.05343, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="486.6840145043136">Twenty-one hours later, the mice were divided into two groups: one was submitted to the water/NaCl 2% choice intake test, while the other was perfused and their brains subjected to the Fos-immunoreactivity (Fos-ir) procedure. Sodium depletion, regardless of genetic sex (XX or XY), induced a significantly lower sodium and water intake in females than in males,</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 429.2px; top: 599.6px; transform: scale(1.02563, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="276.92134158623224">confirming the existence in mice of sexual dimorphism in sodium appetite and the organizational involvement of gonadal steroids. Moreover, our results demonstrate a SCC</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 633.333px; transform: scale(0.999959, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="591.9760176422602">effect on induced brain Fos-ir, showing increased brain activity in XX-SCC mice at the</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 667.067px; transform: scale(1.04449, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.2253509830233">paraventricular nucleus, nucleus of the solitary tract and lateral parabrachial nucleus, as</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 700.8px; transform: scale(1.03925, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.3720176540613">well as an XX-SCC augmented effect on sodium-depletion induced brain activity at two</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 734.533px; transform: scale(1.01565, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="592.1226843132972">circumventricular organs, the subfornical organ and area postrema, nuclei closely involved</div> <div dir="ltr" style="font-size: 14.6667px; font-family: sans-serif; left: 113.6px; top: 768.267px; transform: scale(1.00202, 1); transform-origin: 0% 0% 0px;" data-font-name="g_font_p0_3" data-canvas-width="266.53734127676506">in fluid and blood pressure homeostasis. </div>

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