Current characteristics of methods for determining cardiac troponins and their diagnostic value: a mini-review
The expansion and discovery of new diagnostic possibilities for the use of many biomarkers of cardiovascular diseases (CVDs), including cardiospecific troponin isoforms (cTnI, cTnT), is due to improved laboratory methods for their determination. Throughout a long history of the creation and improvem...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/32988 |
| Aporte de: |
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I10-R10article-32988 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
| repository_str |
R-10 |
| container_title_str |
Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
hs-cTnI hs-cTnT immunochemical methods of determination diagnostics acute myocardial infarction non-invasive diagnostics hs-cTnI hs-cTnT métodos inmunoquímicos de determinación diagnóstico infarto agudo de miocardio diagnóstico no invasivo hs-cTnI hs-cTnT métodos imunoquímicos de determinação diagnóstico infarto agudo do miocárdio diagnóstico não invasivo não financiado conflito de interesses-ausente |
| spellingShingle |
hs-cTnI hs-cTnT immunochemical methods of determination diagnostics acute myocardial infarction non-invasive diagnostics hs-cTnI hs-cTnT métodos inmunoquímicos de determinación diagnóstico infarto agudo de miocardio diagnóstico no invasivo hs-cTnI hs-cTnT métodos imunoquímicos de determinação diagnóstico infarto agudo do miocárdio diagnóstico não invasivo não financiado conflito de interesses-ausente Chaulin, Aleksey Current characteristics of methods for determining cardiac troponins and their diagnostic value: a mini-review |
| topic_facet |
hs-cTnI hs-cTnT immunochemical methods of determination diagnostics acute myocardial infarction non-invasive diagnostics hs-cTnI hs-cTnT métodos inmunoquímicos de determinación diagnóstico infarto agudo de miocardio diagnóstico no invasivo hs-cTnI hs-cTnT métodos imunoquímicos de determinação diagnóstico infarto agudo do miocárdio diagnóstico não invasivo não financiado conflito de interesses-ausente |
| author |
Chaulin, Aleksey |
| author_facet |
Chaulin, Aleksey |
| author_sort |
Chaulin, Aleksey |
| title |
Current characteristics of methods for determining cardiac troponins and their diagnostic value: a mini-review |
| title_short |
Current characteristics of methods for determining cardiac troponins and their diagnostic value: a mini-review |
| title_full |
Current characteristics of methods for determining cardiac troponins and their diagnostic value: a mini-review |
| title_fullStr |
Current characteristics of methods for determining cardiac troponins and their diagnostic value: a mini-review |
| title_full_unstemmed |
Current characteristics of methods for determining cardiac troponins and their diagnostic value: a mini-review |
| title_sort |
current characteristics of methods for determining cardiac troponins and their diagnostic value: a mini-review |
| description |
The expansion and discovery of new diagnostic possibilities for the use of many biomarkers of cardiovascular diseases (CVDs), including cardiospecific troponin isoforms (cTnI, cTnT), is due to improved laboratory methods for their determination. Throughout a long history of the creation and improvement of immunochemical methods for the determination of cTnI and cTnT, significant changes were observed in the concept of biology and its diagnostic value as CVD biomarkers. The obsolete methods of detection of cTnI, cTnT, named low sensitivity and moderate, were distinguished by a relatively low sensitivity, which led to the confirmation late in the diagnosis of acute myocardial infarction (AMI) and, therefore, such methods were gradually replaced by new methods of high and moderate sensitivity, such as definitions of methods, ultra-sensitive (hs-cTnI, hs-cTnT). With the introduction of hs-cTnI and hs-cTnT in clinical practice, the possibility of early diagnosis and exclusion of AMI through the evaluation of the kinetics of the concentration of hs-cTnI and hs-cTnT in the first hours (0-1 hour, 0-2 hours, 0-3 hours) from the moment the patient enters the emergency room. In addition, some of our ideas about the biology of cardiac troponins have changed, and promising new opportunities for their use in medicine have emerged. This manuscript analyzes the key analytical characteristics of hs-cTnI and hs-cTnT detection methods compared to moderately sensitive methods, and reports on new biological data and some new diagnostic possibilities for the use of hs-cTnI and hs-cTnT in modern clinical practice. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/32988 |
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