Central nervous system relapse in diffuse large B lymphoma: a retrospective cohort study: CNS relapse in LDCGB

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Introduction: CNS relapse in patients with LDCGB is a poor prognosis event. The incidence of relapse is variable according to the literature. Data in Latin America is lacking. Methods: In order to establish the incidence of CNS relapse in our cohort, time to CNS relapse and the impact of CNS relapse...

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Autores principales: Warley, Fernando, Cristaldo, Nancy, Colucci, Giuliana, Otero, Victoria
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021
Materias:
lymphoma, non-hodgkin
lymphoma, large b-cell, diffuse
neoplasm recurrence, local
linfoma no hodgkin
recurrencia local de neoplasia
sistema nervioso central
Linfoma de Células B Grandes Difuso
linfoma não-hodgkin
linfoma difuso de grandes células b
recidiva local de neoplasia
sistema nervoso central
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/28183
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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container_title_str Revistas de la UNC
language Español
format Artículo revista
topic lymphoma, non-hodgkin
lymphoma, large b-cell, diffuse
neoplasm recurrence, local
linfoma no hodgkin
recurrencia local de neoplasia
sistema nervioso central
Linfoma de Células B Grandes Difuso
linfoma não-hodgkin
linfoma difuso de grandes células b
recidiva local de neoplasia
sistema nervoso central
spellingShingle lymphoma, non-hodgkin
lymphoma, large b-cell, diffuse
neoplasm recurrence, local
linfoma no hodgkin
recurrencia local de neoplasia
sistema nervioso central
Linfoma de Células B Grandes Difuso
linfoma não-hodgkin
linfoma difuso de grandes células b
recidiva local de neoplasia
sistema nervoso central
Warley, Fernando
Cristaldo, Nancy
Colucci, Giuliana
Otero, Victoria
Central nervous system relapse in diffuse large B lymphoma: a retrospective cohort study: CNS relapse in LDCGB
topic_facet lymphoma, non-hodgkin
lymphoma, large b-cell, diffuse
neoplasm recurrence, local
linfoma no hodgkin
recurrencia local de neoplasia
sistema nervioso central
Linfoma de Células B Grandes Difuso
linfoma não-hodgkin
linfoma difuso de grandes células b
recidiva local de neoplasia
sistema nervoso central
author Warley, Fernando
Cristaldo, Nancy
Colucci, Giuliana
Otero, Victoria
author_facet Warley, Fernando
Cristaldo, Nancy
Colucci, Giuliana
Otero, Victoria
author_sort Warley, Fernando
title Central nervous system relapse in diffuse large B lymphoma: a retrospective cohort study: CNS relapse in LDCGB
title_short Central nervous system relapse in diffuse large B lymphoma: a retrospective cohort study: CNS relapse in LDCGB
title_full Central nervous system relapse in diffuse large B lymphoma: a retrospective cohort study: CNS relapse in LDCGB
title_fullStr Central nervous system relapse in diffuse large B lymphoma: a retrospective cohort study: CNS relapse in LDCGB
title_full_unstemmed Central nervous system relapse in diffuse large B lymphoma: a retrospective cohort study: CNS relapse in LDCGB
title_sort central nervous system relapse in diffuse large b lymphoma: a retrospective cohort study: cns relapse in ldcgb
description Introduction: CNS relapse in patients with LDCGB is a poor prognosis event. The incidence of relapse is variable according to the literature. Data in Latin America is lacking. Methods: In order to establish the incidence of CNS relapse in our cohort, time to CNS relapse and the impact of CNS relapse risk factors, a retrospective cohort study was performed, from January 2012 to June 2017. Results: One hundred and forty seven patients were analyzed. The median age was 66 years (ICR 56-76); 76 patients (51.70%) were men. The IPI was low or intermediate/low in 115 (78.2%) cases. The CNS IPI was intermediate in 77 (52.4%) and high in 14 (9.5%) of cases. Thirty-five (23.81%) patients received intrathecal prophylaxis. No patient received systemic prophylaxis. During the follow-up, 8 (4.59%) patients had CNS relapse, none of them with high IPI. The median time to relapse was 6.5 months (ICR 5.5-10). Seven (87.5%) patients relapsed within the year of diagnosis. We found no risk factors for CNS involvement in the bivariate analysis. The incidence of relapse was 2.7% (CI 0.2% -4.6%), 4.8% (CI 1.8% -8.9%) and 5.4% (CI 4.5- 8.9%) at 6, 12 and 24 months, respectively. Discussion: The incidence of CNS relapse was similar to that described in the international series. Our study confirms that the majority of patients relapse during the first year of follow up. We must carry out broader collaborative work to better establish the risk factor for CNS relapse.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2021
url https://revistas.unc.edu.ar/index.php/med/article/view/28183
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