Chronic a administration of nonsteroidal - antiinflammatory drugs (NDAIDS): effects upon mouse reproductive funcions

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Although nonsteroidal-antiinflamatory drugs (NSAIDs) are widely employed, reproductive side effects of prostaglandins long-term inhibition remain unknown. The objective of the present study wasto evaluate the effects of chronic low/moderate NSAIDs doses upon mice reproductive functions. Male or fema...

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Autores principales: Martini, Ana C, Vincenti, Laura M, Santillán, María E, Stutz, Graciela, Kaplan, Raquel, Ruiz, Rubén D, Fiol de Cuneo, María Marta
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020
Materias:
nonsteroidal-antiinflamatory drugs
prostaglandins
reproduction
sperm functional activity
oocyte
ibuprofen
piroxicam
antiinflamatorios no esteroideos
prostaglandinas
reproducción
actividad funcional espermática
ovocito
ibuprofeno
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/27715
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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institution Universidad Nacional de Córdoba
institution_str I-10
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container_title_str Revistas de la UNC
language Español
format Artículo revista
topic nonsteroidal-antiinflamatory drugs
prostaglandins
reproduction
sperm functional activity
oocyte
ibuprofen
piroxicam
antiinflamatorios no esteroideos
prostaglandinas
reproducción
actividad funcional espermática
ovocito
ibuprofeno
piroxicam
spellingShingle nonsteroidal-antiinflamatory drugs
prostaglandins
reproduction
sperm functional activity
oocyte
ibuprofen
piroxicam
antiinflamatorios no esteroideos
prostaglandinas
reproducción
actividad funcional espermática
ovocito
ibuprofeno
piroxicam
Martini, Ana C
Vincenti, Laura M
Santillán, María E
Stutz, Graciela
Kaplan, Raquel
Ruiz, Rubén D
Fiol de Cuneo, María Marta
Chronic a administration of nonsteroidal - antiinflammatory drugs (NDAIDS): effects upon mouse reproductive funcions
topic_facet nonsteroidal-antiinflamatory drugs
prostaglandins
reproduction
sperm functional activity
oocyte
ibuprofen
piroxicam
antiinflamatorios no esteroideos
prostaglandinas
reproducción
actividad funcional espermática
ovocito
ibuprofeno
piroxicam
author Martini, Ana C
Vincenti, Laura M
Santillán, María E
Stutz, Graciela
Kaplan, Raquel
Ruiz, Rubén D
Fiol de Cuneo, María Marta
author_facet Martini, Ana C
Vincenti, Laura M
Santillán, María E
Stutz, Graciela
Kaplan, Raquel
Ruiz, Rubén D
Fiol de Cuneo, María Marta
author_sort Martini, Ana C
title Chronic a administration of nonsteroidal - antiinflammatory drugs (NDAIDS): effects upon mouse reproductive funcions
title_short Chronic a administration of nonsteroidal - antiinflammatory drugs (NDAIDS): effects upon mouse reproductive funcions
title_full Chronic a administration of nonsteroidal - antiinflammatory drugs (NDAIDS): effects upon mouse reproductive funcions
title_fullStr Chronic a administration of nonsteroidal - antiinflammatory drugs (NDAIDS): effects upon mouse reproductive funcions
title_full_unstemmed Chronic a administration of nonsteroidal - antiinflammatory drugs (NDAIDS): effects upon mouse reproductive funcions
title_sort chronic a administration of nonsteroidal - antiinflammatory drugs (ndaids): effects upon mouse reproductive funcions
description Although nonsteroidal-antiinflamatory drugs (NSAIDs) are widely employed, reproductive side effects of prostaglandins long-term inhibition remain unknown. The objective of the present study wasto evaluate the effects of chronic low/moderate NSAIDs doses upon mice reproductive functions. Male or female mice were injected (i.p. for 60 or 35 days respectively) with: ibuprofen doses A, B or C (0.56, 1.12 or 1.68mg/100g/day respectively) or piroxicam doses A, B or C (0.028, 0.056 or 0.084mg/100g/day respectively). Parameters evaluated were: a) in females, spontaneous and induced ovulation, oocyte maturity and spermatozoa migration through genital tract, b) in males, epididymal spermatozoa concentration, motility, viability, resistance to hypoosmotic shock, acrosomal status and membrane maturity and c) in both genders, in vitro and in vivo fertilization, reproductive hormones plasma levels and cyclooxigenase inhibition in reproductive tissues. In females ibuprofen (dose A) elicited a significant reduction in spontaneous and induced ovulation rates and piroxicam (dose A) diminished the concentration of spermatozoa found in the uterus after mating. Males treated with ibuprofen (dose B) showed a reduction in the in vitro fertilization ability. Our data reveal that chronic administration of ibuprofen or piroxicam can exert detrimental effects upon reproductive physiology, which depends on the doses and/or the drug employed.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2020
url https://revistas.unc.edu.ar/index.php/med/article/view/27715
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