Validation of a high sensitive troponin 99th percentile obtained in a general hospital.
High sensitivity cardiac Troponin T (hs-cTnT) dosage is recommended for myocardial infarction diagnosis, by applying the 99th percentile obtained from a healthy population by the manufacturer. The objective is to validate the 99th percentile in a population from our hospital (99L), compared with the...
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2020
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/27473 |
| Aporte de: |
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I10-R10article-27473 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-10 |
| container_title_str |
Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
Troponin T myocardial infarction validation studies Troponina T infarto de miocardio estudios de validación Troponina T infarto do miocárdio estudos de validação |
| spellingShingle |
Troponin T myocardial infarction validation studies Troponina T infarto de miocardio estudios de validación Troponina T infarto do miocárdio estudos de validação Martínez, María Laura Bertazzo, Brunella Bianca Gonzalez Grima, Juan Figueroa Córdoba, Ana Virginia Konicoff, Mailen Martina, Luciana Rossa, Victoria Amuchastegui, Marcos Brenna, Eduardo Javier Salomone, Oscar Ferrero Guadagnoli, Adolfo Contreras, Alejandro Ernesto Validation of a high sensitive troponin 99th percentile obtained in a general hospital. |
| topic_facet |
Troponin T myocardial infarction validation studies Troponina T infarto de miocardio estudios de validación Troponina T infarto do miocárdio estudos de validação |
| author |
Martínez, María Laura Bertazzo, Brunella Bianca Gonzalez Grima, Juan Figueroa Córdoba, Ana Virginia Konicoff, Mailen Martina, Luciana Rossa, Victoria Amuchastegui, Marcos Brenna, Eduardo Javier Salomone, Oscar Ferrero Guadagnoli, Adolfo Contreras, Alejandro Ernesto |
| author_facet |
Martínez, María Laura Bertazzo, Brunella Bianca Gonzalez Grima, Juan Figueroa Córdoba, Ana Virginia Konicoff, Mailen Martina, Luciana Rossa, Victoria Amuchastegui, Marcos Brenna, Eduardo Javier Salomone, Oscar Ferrero Guadagnoli, Adolfo Contreras, Alejandro Ernesto |
| author_sort |
Martínez, María Laura |
| title |
Validation of a high sensitive troponin 99th percentile obtained in a general hospital. |
| title_short |
Validation of a high sensitive troponin 99th percentile obtained in a general hospital. |
| title_full |
Validation of a high sensitive troponin 99th percentile obtained in a general hospital. |
| title_fullStr |
Validation of a high sensitive troponin 99th percentile obtained in a general hospital. |
| title_full_unstemmed |
Validation of a high sensitive troponin 99th percentile obtained in a general hospital. |
| title_sort |
validation of a high sensitive troponin 99th percentile obtained in a general hospital. |
| description |
High sensitivity cardiac Troponin T (hs-cTnT) dosage is recommended for myocardial infarction diagnosis, by applying the 99th percentile obtained from a healthy population by the manufacturer. The objective is to validate the 99th percentile in a population from our hospital (99L), compared with the manufacturer´s 99th percentile (99F) by using coronary angiography as gold standard.
Materials and method:
Retrospective analysis of every hs-cTnT (Roche) obtained from patients admitted with acute coronary syndromes (ACS) who underwent coronary angiography between 2015 and 2018.
Results:
415 patients were included for analysis (118 females, 64.2 yo). 99F sensitivity (Sn) for significant coronary artery disease (stenosis >70%) was 83.6%, with a specificity (Sp) of 44.5%. Positive predictive value (PPV) and negative predictive value (NPV) were 77% and 55% respectively. 99L Sn was 69.7% and Sp 58.6%. PPV was 79% and NPV 46%. ROC curve was 0.641 for 99F and 0.641 for 99L.
Conclusion:
Given the importance of hs-cTnT in ACS diagnosis, the 99F should be the preferred upper reference limit since the sensitivity is better, although lower compared to prior studies. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2020 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/27473 |
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