EGFR gene mutation, ALK and PDL-1 expression in non-small cell lung cancer. Local and multicenter study

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During the last decades there have been changes in the epidemiology of non-small cell lung cancer (NSCLC), there was an increase in the histologicallineage adenocarcinoma. Substantial progress has been made in the characterization of molecular abnormalities in the EGFR gene, ALK gene fusion andPDL-1...

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Autores principales: Pilnik , Norma, Bengió , V, Canigiani , Maximiliano, Maldini , C
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019
Materias:
lungcancer
EGFR
ALK
PDL-1
adenocarcinoma
cáncer de pulmón
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/25543
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic lungcancer
EGFR
ALK
PDL-1
adenocarcinoma
cáncer de pulmón
EGFR
ALK
PDL-1
adenocarcinoma
spellingShingle lungcancer
EGFR
ALK
PDL-1
adenocarcinoma
cáncer de pulmón
EGFR
ALK
PDL-1
adenocarcinoma
Pilnik , Norma
Bengió , V
Canigiani , Maximiliano
Maldini , C
EGFR gene mutation, ALK and PDL-1 expression in non-small cell lung cancer. Local and multicenter study
topic_facet lungcancer
EGFR
ALK
PDL-1
adenocarcinoma
cáncer de pulmón
EGFR
ALK
PDL-1
adenocarcinoma
author Pilnik , Norma
Bengió , V
Canigiani , Maximiliano
Maldini , C
author_facet Pilnik , Norma
Bengió , V
Canigiani , Maximiliano
Maldini , C
author_sort Pilnik , Norma
title EGFR gene mutation, ALK and PDL-1 expression in non-small cell lung cancer. Local and multicenter study
title_short EGFR gene mutation, ALK and PDL-1 expression in non-small cell lung cancer. Local and multicenter study
title_full EGFR gene mutation, ALK and PDL-1 expression in non-small cell lung cancer. Local and multicenter study
title_fullStr EGFR gene mutation, ALK and PDL-1 expression in non-small cell lung cancer. Local and multicenter study
title_full_unstemmed EGFR gene mutation, ALK and PDL-1 expression in non-small cell lung cancer. Local and multicenter study
title_sort egfr gene mutation, alk and pdl-1 expression in non-small cell lung cancer. local and multicenter study
description During the last decades there have been changes in the epidemiology of non-small cell lung cancer (NSCLC), there was an increase in the histologicallineage adenocarcinoma. Substantial progress has been made in the characterization of molecular abnormalities in the EGFR gene, ALK gene fusion andPDL-1 expression in NSCLC, which are being used as molecular targets and predictive biomarkers.The purpose of this study was to determine the frequency of molecular alterations in the EGFR gene, ALK gene fusion and PD-L1 expression and toevaluate the association with age, gender and tobacco habit in the local population.We studied 171 biopsies and resection samples from patients (pts) with NSCLC during the period 2014 - 2019. Characteristics of histopathological type,immunohistochemical (IHC) and molecular profile were analyzed, a subgroup of 39 pts was analyzed for PD-L1 expression. Molecular profiles werecorrelated with different clinical variables (age, sex and tobacco use). Qualitative variables were compared with the chi-square or Fisher test andquantitative variables were compared with the Test-T.Tobacco use was associated with sex 29.82% and 59% of smokers were women and men, respectively (p = 0.012). Women were younger than men (p =0.032). EGFR alterations ware associated with sex (p = 0.002), women were more likely to have positive gene alterations. Only 1.8% of subjects reportedALK alterations and they were not related to sex (p = 0.55). In a patients subgroup where PD-L1 was tested, univariate analysis showed no association ofPD-L1 expression with sex (p = 0.3006), age (p = 0.7747), tobacco habit (p = 1) and EGFR gene mutation (p = 1).The results showed a frequency of expression of mutations in EGFR and ALK fusion oncogene comparable to the data reported in the westernpopulation. The alterations present in the EGFR are the most prevalent in women with adenocarcinoma. Keywords: lungcancer; EGFR; ALK; adenocarcinoma  
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2019
url https://revistas.unc.edu.ar/index.php/med/article/view/25543
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