Genetic of obesity
Background: Obesity is a complex phenomenon that involves interactions between environmental and genetics factors. The genetic studies in animal models and humans has allowed great progress in the knowledge of body weight regulation. Identifying the hypothalamic leptin/melanocortin pathway as critic...
Guardado en:
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| Formato: | Artículo revista |
| Lenguaje: | Inglés |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/23569 |
| Aporte de: |
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I10-R10article-23569 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-10 |
| container_title_str |
Revistas de la UNC |
| language |
Inglés |
| format |
Artículo revista |
| topic |
obesidad genética niño adolescente obesity genetics child adolescent |
| spellingShingle |
obesidad genética niño adolescente obesity genetics child adolescent Cuestas, Eduardo Genetic of obesity |
| topic_facet |
obesidad genética niño adolescente obesity genetics child adolescent |
| author |
Cuestas, Eduardo |
| author_facet |
Cuestas, Eduardo |
| author_sort |
Cuestas, Eduardo |
| title |
Genetic of obesity |
| title_short |
Genetic of obesity |
| title_full |
Genetic of obesity |
| title_fullStr |
Genetic of obesity |
| title_full_unstemmed |
Genetic of obesity |
| title_sort |
genetic of obesity |
| description |
Background: Obesity is a complex phenomenon that involves interactions between environmental and genetics factors. The genetic studies in animal models and humans has allowed great progress in the knowledge of body weight regulation. Identifying the hypothalamic leptin/melanocortin pathway as critical in many cases of monogenic obesity has permitted targeted, hypothesis-driven experiments to be performed, and has implicated new candidates as causative for previously uncharacterized clinical cases of obesity.Data sources: Narrative review. PubMed, Lilacs and ScieLo databases were searched with the terms “obesity”, “genetics” and limited only for “ all child 0-18 years”.Results: Numerous studies in children and adolescents, have tried to identify candidate genes. At present, the results are not conclusive. Thus, is yet premature genotype obese child on a large scale for predictive testing. Meanwhile, the effects of mutations in the melanocortin-4 receptor gene, for which the obese phenotype varies in the degree of severity among individuals, are now thought to be influenced by one's environmental surroundings. Molecular approaches have revealed that syndromes previously assumed to be controlled by a single gene are conversely regulated by multiple elements.Conclusions: When specific treatments based on recent discoveries become available, genetic testing could help to discriminate different types of obesity that may respond differentially to therapeutic measures. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2019 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/23569 |
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AT cuestaseduardo geneticofobesity AT cuestaseduardo geneticayobesidad |
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Revistas |
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1764819782064930820 |