Carbapenems resistance in Pseudomonas aeruginosa during a 10-year period at Rawson Hospital

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Backgrounds: Pae is a non-fermenting, Gram-negative bacillus that is associated with nosocomial infections and can easily be transmitted through the hands of health staff from patient to patient. Pae has a wide variety of natural resistance mechanisms and a great capacity to acquire new resistance m...

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Autores principales: Orecchini, Luisa A., López, Teresa, Littvik, Ana
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2010
Materias:
carbapenemes
pseudomonas aeruginosa
carbapenems
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/22565
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10article-22565
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic carbapenemes
pseudomonas aeruginosa
carbapenems
pseudomonas aeruginosa
spellingShingle carbapenemes
pseudomonas aeruginosa
carbapenems
pseudomonas aeruginosa
Orecchini, Luisa A.
López, Teresa
Littvik, Ana
Carbapenems resistance in Pseudomonas aeruginosa during a 10-year period at Rawson Hospital
topic_facet carbapenemes
pseudomonas aeruginosa
carbapenems
pseudomonas aeruginosa
author Orecchini, Luisa A.
López, Teresa
Littvik, Ana
author_facet Orecchini, Luisa A.
López, Teresa
Littvik, Ana
author_sort Orecchini, Luisa A.
title Carbapenems resistance in Pseudomonas aeruginosa during a 10-year period at Rawson Hospital
title_short Carbapenems resistance in Pseudomonas aeruginosa during a 10-year period at Rawson Hospital
title_full Carbapenems resistance in Pseudomonas aeruginosa during a 10-year period at Rawson Hospital
title_fullStr Carbapenems resistance in Pseudomonas aeruginosa during a 10-year period at Rawson Hospital
title_full_unstemmed Carbapenems resistance in Pseudomonas aeruginosa during a 10-year period at Rawson Hospital
title_sort carbapenems resistance in pseudomonas aeruginosa during a 10-year period at rawson hospital
description Backgrounds: Pae is a non-fermenting, Gram-negative bacillus that is associated with nosocomial infections and can easily be transmitted through the hands of health staff from patient to patient. Pae has a wide variety of natural resistance mechanisms and a great capacity to acquire new resistance mechanisms or to increase the expression of their natural resistance. Carbapenems resistance may be offered by impermeability mechanisms, increase in the efflux or enzymatic pump (production of carbapenemases).Purpose: To determine prevailing carbapenems resistance mechanisms in Pae and their evolution.Materials and methods: 372 Pae strains were collected during a ten-year period. The strains were identified through biochemical tests and performed a sensitivity test through diffusion and microbiological method.Results: carbapenems resistance mechanisms for efflux in the year 2000 were, 50%; 2001 16.6%, 2002 6.3%, 2003 23.9%, 2004 18%, 2005 8.8%, 2006 17.8%, 2007 31.8%, 2008 2.5%, 2009 5.2%. As regards impermeability: 2000 33%, 2001 21.4%, 2002 8.5%, 2003 30.4%, 2004 14.7%, 2005 28.8%, 2006 23.5%, 2007 13.6%, 2008 2.5%, 2009 5.2%. The microbiological test was negative for all studied strains.Conclusion: carbapenems resistance during this period was offered by impermeability and an increase in the expression of the efflux mechanism, not by enzymatic mechanism in our hospital. This is a very important issue from an epidemiological point of view because of the rapid horizontal transmission of the strains with this resistance mechanism.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2010
url https://revistas.unc.edu.ar/index.php/med/article/view/22565
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