IL-6, MMP 3 and prognosis in previously healthy sepsis patients

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Sepsis and septic shock are clinical conditions with high mortality despite advances in technology and are the leading cause of death in intensive care. Clinical manifestations and morbidity may be attributable to a disproportionate increase in proinflammatory cytokines. The aim of this study was to...

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Autores principales: Ricarte-Bratti, Juan Pablo, Jaime-Albarrán, Nicolas, Montrull, Hilda Lucrecia, Brizuela, Nilda Yolanda
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
Sepsis
Cytokines
Matrix Metalloproteases
Interleukin 6
Prognosis
Mortality
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/14608
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10article-14608
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Inglés
format Artículo revista
topic Sepsis
Cytokines
Matrix Metalloproteases
Interleukin 6
Prognosis
Mortality
spellingShingle Sepsis
Cytokines
Matrix Metalloproteases
Interleukin 6
Prognosis
Mortality
Ricarte-Bratti, Juan Pablo
Jaime-Albarrán, Nicolas
Montrull, Hilda Lucrecia
Brizuela, Nilda Yolanda
IL-6, MMP 3 and prognosis in previously healthy sepsis patients
topic_facet Sepsis
Cytokines
Matrix Metalloproteases
Interleukin 6
Prognosis
Mortality
author Ricarte-Bratti, Juan Pablo
Jaime-Albarrán, Nicolas
Montrull, Hilda Lucrecia
Brizuela, Nilda Yolanda
author_facet Ricarte-Bratti, Juan Pablo
Jaime-Albarrán, Nicolas
Montrull, Hilda Lucrecia
Brizuela, Nilda Yolanda
author_sort Ricarte-Bratti, Juan Pablo
title IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_short IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_full IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_fullStr IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_full_unstemmed IL-6, MMP 3 and prognosis in previously healthy sepsis patients
title_sort il-6, mmp 3 and prognosis in previously healthy sepsis patients
description Sepsis and septic shock are clinical conditions with high mortality despite advances in technology and are the leading cause of death in intensive care. Clinical manifestations and morbidity may be attributable to a disproportionate increase in proinflammatory cytokines. The aim of this study was to evaluate the ability to predict mortality from interleukin 6 [IL-6] and matrix metalloproteinase 3 [MMP-3]. This single-center, observational, prospective study included 48 adult patients admitted to the Hospital Nacional de Clinicas in Cordoba, Argentina, with sepsis or septic shock. Serum levels of IL-6 and MMP-3 were measured at the time of diagnosis and 72 hours later. At time of admission, MMP-3 was 13.77 mg/ml in patients who died and 10.55 mg/ml in patients who survived up to 28 days after hospitalization [p = 0.012], while IL-6 did not differ between the groups. The change in IL-6 over 72 hours was increased in nonsurvivors by 21.11 ± 11.81 pg/ml and decreased in survivors by 40.87 ± 14.94 pg/ml [p = 0.007]. No difference in the change of MMP-3 over 72 hours was observed between survivors and nonsurvivors. This study shows that MMP-3 at admission and the change in IL-6 over the first 72 hours of hospitalization could provide prognostic information in septic patients. Further studies are needed to define the utility of these cytokines as a measure of sepsis severity and as predictors of mortality.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/14608
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AT jaimealbarrannicolas il6mmp3andprognosisinpreviouslyhealthysepsispatients
AT montrullhildalucrecia il6mmp3andprognosisinpreviouslyhealthysepsispatients
AT brizuelanildayolanda il6mmp3andprognosisinpreviouslyhealthysepsispatients
bdutipo_str Revistas
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