Weight changes in patients subjected to total thyroidectomy for thyroid cancer
Abstract: Thyroid cancer usually affects overweight and obese patients. Total thyroidectomy is associated to weight gain, which in turn is linked to the need for dosage changes in treatment and more aggressive characteristics of the disease. 1- Analyze changes in weight and body mass...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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I10-R10-article-34860 |
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Universidad Nacional de Córdoba |
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Revistas de la UNC |
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Artículo revista |
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thyroid cancer thyroidectomy weight cáncer de tiroides tiroidectomía ponderal . |
| spellingShingle |
thyroid cancer thyroidectomy weight cáncer de tiroides tiroidectomía ponderal . Prietto , DS Geres , A Olivero, M Mereshian , P Weight changes in patients subjected to total thyroidectomy for thyroid cancer |
| topic_facet |
thyroid cancer thyroidectomy weight cáncer de tiroides tiroidectomía ponderal . |
| author |
Prietto , DS Geres , A Olivero, M Mereshian , P |
| author_facet |
Prietto , DS Geres , A Olivero, M Mereshian , P |
| author_sort |
Prietto , DS |
| title |
Weight changes in patients subjected to total thyroidectomy for thyroid cancer |
| title_short |
Weight changes in patients subjected to total thyroidectomy for thyroid cancer |
| title_full |
Weight changes in patients subjected to total thyroidectomy for thyroid cancer |
| title_fullStr |
Weight changes in patients subjected to total thyroidectomy for thyroid cancer |
| title_full_unstemmed |
Weight changes in patients subjected to total thyroidectomy for thyroid cancer |
| title_sort |
weight changes in patients subjected to total thyroidectomy for thyroid cancer |
| description |
Abstract:
Thyroid cancer usually affects overweight and obese patients. Total thyroidectomy is associated to weight gain, which in turn is linked to the need for dosage changes in treatment and more aggressive characteristics of the disease.
1- Analyze changes in weight and body mass index (BMI) in totally thyroidectomized patients. 2- Study pre and postsurgical weight changes according to age, sex, and treatment with levothyroxine (LT4).
This is a longitudinal analytic observational study. We examined 52 thyroidectomized patients. We recorded weight and pre and postsurgical BMI after 6 to 12 months (POP 6-12) and after 13 to 24 months (POP 13-24). We applied paired t-tests to intragroup and interperiod comparisons. Significance level was <0.05.
We evaluated 9 men (20%) and 43 women (80%). The age of women and men was X=52.5±15.2 and 46.4±16.3 years, respectively.
BMI (kg/m2): Women before surgery: 28±6.3; POP 6-12: 27.7±5.6 (p=0.79); POP 13-24: 27.9±6.6 (p=0.9). Men before surgery 27.5±2.9; POP 6-12: 26.8±1.7 (p=0.4); POP 13-24: 28.9±3.2 (p=0.08). The difference in BMI between sexes in all periods was p>0.05.
Weight (kg): Women before surgery: 71.9±15.6; POP 6-12: 71.3±13.9 (p=0.88), POP 13-24: 71.7±15.6 (p=0.73). Men before surgery: 83.7±9.7; POP 6-12: 86.4±9.4 (p=0.5); POP 13-24: 89.6±8.2 (p=0.08).
Weight (kg) by age group: <40 years old (n=11, 22%) before surgery: 67.4±19.1; POP 6-12: 68.7±19.8 (p=0.76); POP 13-24:70.3±19.8 (p=0.45). 40-59 years old (n=22, 43%) before surgery: 76.1±12.7; POP 6-12: 76±12.2 (p=0.9); POP 13-24: 77.1±12.2 (p=0.3). ≥60 years old (n=19, 35%) before surgery: 75.3±15.6; POP 6-12: 77± 3.2 (p=0.13); POP 13-24: 76±17.1 (p=0.65).
BMI (kg/m2) by age group: <40 years old before surgery: 23.7±3.8; POP 6-12: 23.9±3.7 (p=0.86); POP 13-24: 24.2±3.9 (p=0.4). 40-59 years old before surgery: 28.1±5.3; POP 6-12: 28.1±5.1 (p=0.9); POP 13-24: 28.6±5.9 (p=0.23). ≥60 years old before surgery: 30±6.3; POP 6-12: 30.5±4.7 (p=0.12); POP 13-24: 30±6.5 (p=0.62).
Weight (kg) according to presurgical LT4: With LT4 (n=19, 36%): before surgery: 73.6±14.9; POP 6-12: 74.9±14.7 (p=0.81); POP 13-24: 73.9±15.8 (p=0.69). Without LT4 (n=33, 64%): before surgery: 74.5±15.8; POP 6-12: 74.4±14.4 (p=0.36); POP 13-24: 76.3±16.5 (p=0.44).
The relationship between weight at 6 to 12 months and postsurgical LT4 dose was r= 0.01, p<0.05.
Our population was characterized by being overweight and obese and did not show postsurgical weight changes according to age, sex and previous treatment with LT4.
Higher postsurgical LT4 doses were inversely related to weight in the first postsurgical period.
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| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/34860 |
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2022-10-04T12:56:15Z |
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I10-R10-article-348602022-06-07T14:43:30Z Weight changes in patients subjected to total thyroidectomy for thyroid cancer Variaciones ponderales en pacientes sometidos a tiroidectomía total por cáncer de tiroides A Prietto , DS Geres , A Olivero, M Mereshian , P thyroid cancer thyroidectomy weight cáncer de tiroides tiroidectomía ponderal . Abstract: Thyroid cancer usually affects overweight and obese patients. Total thyroidectomy is associated to weight gain, which in turn is linked to the need for dosage changes in treatment and more aggressive characteristics of the disease. 1- Analyze changes in weight and body mass index (BMI) in totally thyroidectomized patients. 2- Study pre and postsurgical weight changes according to age, sex, and treatment with levothyroxine (LT4). This is a longitudinal analytic observational study. We examined 52 thyroidectomized patients. We recorded weight and pre and postsurgical BMI after 6 to 12 months (POP 6-12) and after 13 to 24 months (POP 13-24). We applied paired t-tests to intragroup and interperiod comparisons. Significance level was <0.05. We evaluated 9 men (20%) and 43 women (80%). The age of women and men was X=52.5±15.2 and 46.4±16.3 years, respectively. BMI (kg/m2): Women before surgery: 28±6.3; POP 6-12: 27.7±5.6 (p=0.79); POP 13-24: 27.9±6.6 (p=0.9). Men before surgery 27.5±2.9; POP 6-12: 26.8±1.7 (p=0.4); POP 13-24: 28.9±3.2 (p=0.08). The difference in BMI between sexes in all periods was p>0.05. Weight (kg): Women before surgery: 71.9±15.6; POP 6-12: 71.3±13.9 (p=0.88), POP 13-24: 71.7±15.6 (p=0.73). Men before surgery: 83.7±9.7; POP 6-12: 86.4±9.4 (p=0.5); POP 13-24: 89.6±8.2 (p=0.08). Weight (kg) by age group: <40 years old (n=11, 22%) before surgery: 67.4±19.1; POP 6-12: 68.7±19.8 (p=0.76); POP 13-24:70.3±19.8 (p=0.45). 40-59 years old (n=22, 43%) before surgery: 76.1±12.7; POP 6-12: 76±12.2 (p=0.9); POP 13-24: 77.1±12.2 (p=0.3). ≥60 years old (n=19, 35%) before surgery: 75.3±15.6; POP 6-12: 77± 3.2 (p=0.13); POP 13-24: 76±17.1 (p=0.65). BMI (kg/m2) by age group: <40 years old before surgery: 23.7±3.8; POP 6-12: 23.9±3.7 (p=0.86); POP 13-24: 24.2±3.9 (p=0.4). 40-59 years old before surgery: 28.1±5.3; POP 6-12: 28.1±5.1 (p=0.9); POP 13-24: 28.6±5.9 (p=0.23). ≥60 years old before surgery: 30±6.3; POP 6-12: 30.5±4.7 (p=0.12); POP 13-24: 30±6.5 (p=0.62). Weight (kg) according to presurgical LT4: With LT4 (n=19, 36%): before surgery: 73.6±14.9; POP 6-12: 74.9±14.7 (p=0.81); POP 13-24: 73.9±15.8 (p=0.69). Without LT4 (n=33, 64%): before surgery: 74.5±15.8; POP 6-12: 74.4±14.4 (p=0.36); POP 13-24: 76.3±16.5 (p=0.44). The relationship between weight at 6 to 12 months and postsurgical LT4 dose was r= 0.01, p<0.05. Our population was characterized by being overweight and obese and did not show postsurgical weight changes according to age, sex and previous treatment with LT4. Higher postsurgical LT4 doses were inversely related to weight in the first postsurgical period. Resumen: El cáncer tiroideo suele presentarse en pacientes con sobrepeso y obesidad. La tiroidectomía total asociase a ganancia ponderal, entidad esta, que a su vez se vincula a necesidad de cambios posológicos en el tratamiento y características más agresivas de la enfermedad. 1- Analizar modificaciones de peso e índice de masa corporal (IMC) en tiroidectomizados totales. 2- Estudiar cambios ponderales pre y postquirúrgicos en función a edad, sexo y tratamiento con levotiroxina (LT4). Estudio observacional analítico longitudinal. Examinamos 52 tiroidectomizados. Registramos peso, IMC basal prequirúrgico y a los 6-12 (POP 6-12) y 13-24 meses (POP 13-24) postcirugía. Aplicamos test T apareado para las comparaciones intragrupo y entre periodos. Nivel de significación <0,05. Evaluamos 9 hombres (20%) y 43 mujeres (80%). Edad de mujeres y hombres: X=52,5±15,2; 46,4±16,3 años, respectivamente. IMC (Kg/m2): Mujeres, basal: 28±6,3; POP 6-12 meses: 27,7±5,6(p=0,79); POP 13-24 meses: 27,9±6,6(p=0,9). Hombres: basal 27,5±2,9; POP 6-12 meses: 26,8±1,7(p=0,4); POP 13-24 meses: 28,9±3,2(p=0,08). Diferencia de IMC entre sexos en todos los períodos (p>0,05). Peso (Kg): Mujeres, basal:71,9±15,6; POP 6-12 meses: 71,3±13,9(p=0,88), POP 13-24 meses:71,7±15,6(p=0,73). Hombres: basal:83,7±9,7; POP 6-12 meses: 86,4±9,4(p=0,5); POP 13-24 meses:89,6±8,2(p=0,08). Por grupo etario, peso (Kg): <40 años (n=11, 22%): basal:67,4±19,1; POP 6-12 meses: 68,7±19,8(p=0,76); POP 13-24 meses:70,3±19,8(p=0,45). 40-59 años (n=22, 43%) Basal: 76,1±12,7; POP 6-12 meses: 76±12,2(p=0,9); POP 13-24 meses: 77,1±12,2 (p=0,3). ≥60 años (n=19, 35%): basal: 75,3±15,6; POP 6-12 meses: 77± 3,2(p=0,13); POP 13-24 meses: 76±17,1(p=0,65). Por grupo etario, IMC (Kg/m2): <40 años, basal:23,7±3,8; POP 6-12 meses: 23,9±3,7 (p=0,86); POP 13-24 meses:24,2±3,9 (p=0,4). 40-59 años, basal: 28,1±5,3; POP 6-12 meses: 28,1±5,1(p=0,9); POP 13-24 meses: 28,6±5,9(p=0,23). ≥60 años, basal:30±6,3; POP 6-12: 30,5±4,7(p=0,12); POP 13-24: 30±6,5(p=0,62). Según LT4 prequirúrgica, peso (Kg): Con LT4 (n=19, 36%): basal:73,6±14,9; POP 6-12 meses: 74,9±14,7(p=0,81); POP 13-24 meses: 73,9±15,8(p=0,69). Sin LT4 (n=33, 64%): basal:74,5±15,8; POP 6-12: 74,4±14,4(p=0,36); POP 13-24:76,3±16,5(p=0,44). Relación entre peso 6-12 meses y dosis LT4 postquirúrgica r= 0,01, p<0,05. Nuestra población caracterizase por tener sobrepeso y obesidad no demostrando cambios ponderales postquirúrgicos ni en función a edad, sexo y/o tratamiento previo con LT4. Mayores dosis de LT4 postquirúrgicas relacionanse inversamente al peso del primer periodo postoperatorio . Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/34860 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |