Primary effusion lymphoma with multisystemic extracavitary involvement in HIV negative diagnosed by autopsy
Introduction: Primary effusion lymphoma is a low-frequency and high-grade non-Hodgkin lymphoma caused by the Human Herpes virus 8. It mainly affects individuals infected with the human immunodeficiency virus (HIV), although it has also been described in HIV-negative cases. It is characterized by the...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/32945 |
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I10-R10-article-32945 |
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Universidad Nacional de Córdoba |
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Revistas de la UNC |
| language |
Español |
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Artículo revista |
| topic |
lymphoma, primary effusion lymphoma, non-Hodgkin pleural effusion ascites Hematology linfoma de efusión primaria linfoma no Hodgkin derrame pleural ascitis Hematologia linfoma de efusão primária linfoma não Hodgkin derrame pleural ascite hematologia |
| spellingShingle |
lymphoma, primary effusion lymphoma, non-Hodgkin pleural effusion ascites Hematology linfoma de efusión primaria linfoma no Hodgkin derrame pleural ascitis Hematologia linfoma de efusão primária linfoma não Hodgkin derrame pleural ascite hematologia Milanesio, Martín Sánchez, Ana Victoria Guanchiale, Luciana Kaplan, Ruth Lía Primary effusion lymphoma with multisystemic extracavitary involvement in HIV negative diagnosed by autopsy |
| topic_facet |
lymphoma, primary effusion lymphoma, non-Hodgkin pleural effusion ascites Hematology linfoma de efusión primaria linfoma no Hodgkin derrame pleural ascitis Hematologia linfoma de efusão primária linfoma não Hodgkin derrame pleural ascite hematologia |
| author |
Milanesio, Martín Sánchez, Ana Victoria Guanchiale, Luciana Kaplan, Ruth Lía |
| author_facet |
Milanesio, Martín Sánchez, Ana Victoria Guanchiale, Luciana Kaplan, Ruth Lía |
| author_sort |
Milanesio, Martín |
| title |
Primary effusion lymphoma with multisystemic extracavitary involvement in HIV negative diagnosed by autopsy |
| title_short |
Primary effusion lymphoma with multisystemic extracavitary involvement in HIV negative diagnosed by autopsy |
| title_full |
Primary effusion lymphoma with multisystemic extracavitary involvement in HIV negative diagnosed by autopsy |
| title_fullStr |
Primary effusion lymphoma with multisystemic extracavitary involvement in HIV negative diagnosed by autopsy |
| title_full_unstemmed |
Primary effusion lymphoma with multisystemic extracavitary involvement in HIV negative diagnosed by autopsy |
| title_sort |
primary effusion lymphoma with multisystemic extracavitary involvement in hiv negative diagnosed by autopsy |
| description |
Introduction: Primary effusion lymphoma is a low-frequency and high-grade non-Hodgkin lymphoma caused by the Human Herpes virus 8. It mainly affects individuals infected with the human immunodeficiency virus (HIV), although it has also been described in HIV-negative cases. It is characterized by the presence of a malignant lymphomatous effusion in the different serous cavities, the pleural cavity being the most affected. Involvement outside the serosae is very rare. Diagnosis is made by analysis of the fluid accumulated in the serosae or by biopsy of the same, demonstrating the presence of characteristic neoplastic lymphocytes. Treatment consists of different chemotherapy regimens associated with antiretroviral therapy in HIV-positive patients. The prognosis of this disease is poor, with a survival of a few months after diagnosis.
Methodology: We present the case of an 83-year-old man, HIV negative, with left pleural effusion and ascites, observing a fluid with a predominance of mononuclear cells without the presence of malignant cells on cytological examination.
Results: The patient died and the autopsy made the diagnosis of Primary effusion lymphoma, also observing multisystemic extracavitary involvement.
Conclusion: Although Primary effusion lymphoma preferentially affects HIV-positive individuals, the absence of HIV infection should not rule out the disease. Extracavitary involvement should be sought even in asymptomatic patients. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/32945 |
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2022-08-20T01:27:51Z |
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I10-R10-article-329452021-12-29T20:14:46Z Primary effusion lymphoma with multisystemic extracavitary involvement in HIV negative diagnosed by autopsy Linfoma primario de las efusiones con afectación extracavitaria multisistémica en HIV negativo diagnosticado mediante autopsia Linfoma primário de efusões com envolvimento extracavitário multissistêmico em HIV negativo diagnosticado por autópsia Milanesio, Martín Sánchez, Ana Victoria Guanchiale, Luciana Kaplan, Ruth Lía lymphoma, primary effusion lymphoma, non-Hodgkin pleural effusion ascites Hematology linfoma de efusión primaria linfoma no Hodgkin derrame pleural ascitis Hematologia linfoma de efusão primária linfoma não Hodgkin derrame pleural ascite hematologia Introduction: Primary effusion lymphoma is a low-frequency and high-grade non-Hodgkin lymphoma caused by the Human Herpes virus 8. It mainly affects individuals infected with the human immunodeficiency virus (HIV), although it has also been described in HIV-negative cases. It is characterized by the presence of a malignant lymphomatous effusion in the different serous cavities, the pleural cavity being the most affected. Involvement outside the serosae is very rare. Diagnosis is made by analysis of the fluid accumulated in the serosae or by biopsy of the same, demonstrating the presence of characteristic neoplastic lymphocytes. Treatment consists of different chemotherapy regimens associated with antiretroviral therapy in HIV-positive patients. The prognosis of this disease is poor, with a survival of a few months after diagnosis. Methodology: We present the case of an 83-year-old man, HIV negative, with left pleural effusion and ascites, observing a fluid with a predominance of mononuclear cells without the presence of malignant cells on cytological examination. Results: The patient died and the autopsy made the diagnosis of Primary effusion lymphoma, also observing multisystemic extracavitary involvement. Conclusion: Although Primary effusion lymphoma preferentially affects HIV-positive individuals, the absence of HIV infection should not rule out the disease. Extracavitary involvement should be sought even in asymptomatic patients. Introducción: El Linfoma primario de las efusiones es un Linfoma no Hodgkin de alto grado y escasa frecuencia producido por el virus Herpes Humano 8. Afecta principalmente a individuos infectados por el virus de la inmunodeficiencia humana (HIV), aunque también se ha descripto en HIV negativos. Se caracteriza por la presencia de derrame linfomatoso maligno en las distintas cavidades serosas siendo la cavidad pleural la más afectada. La afectación fuera de las serosas es muy poco frecuente. El diagnóstico se realiza por análisis del líquido acumulado en las serosas o mediante biopsia de las mismas demostrando la presencia de linfocitos neoplásicos característicos. El tratamiento consiste en distintos regímenes de quimioterapia asociados a terapia antirretroviral en pacientes HIV positivos. El pronóstico de esta enfermedad es pobre, con una supervivencia de escasos meses posteriores al diagnóstico. Metodología: Presentamos el caso de un varón de 83 años, HIV negativo, con derrame pleural izquierdo y ascitis, observándose un líquido con predominio de mononucleares sin presencia de células malignas al examen citológico. Resultados: El paciente falleció y mediante la autopsia se llegó al diagnóstico de Linfoma primario de las efusiones, observándose además afectación extracavitaria multisistémica. Conclusión: Si bien el Linfoma primario de las efusiones afecta preferentemente a individuos HIV positivos, la ausencia de infección por HIV no debe descartar la enfermedad. El compromiso extracavitario debe ser buscado aún en pacientes asintomáticos. Introdução: O linfoma de derrame primário é um linfoma não Hodgkin de alto grau raro, causado pelo vírus do herpes humano 8. Afeta principalmente indivíduos infectados com o vírus da imunodeficiência humana (HIV), embora também tenha sido descrito em casos HIV negativos. É caracterizada pela presença de derrame linfomatoso maligno nas diferentes cavidades serosas, sendo a cavidade pleural a mais acometida. O envolvimento fora da serosa é muito raro. O diagnóstico é feito pela análise do líquido acumulado na serosa ou por biópsia da mesma, demonstrando a presença de linfócitos neoplásicos característicos. O tratamento consiste em diferentes regimes de quimioterapia associados à terapia antirretroviral em pacientes HIV-positivos. O prognóstico da doença é ruim, com sobrevida de alguns meses após o diagnóstico. Metodologia: Apresentamos o caso de um homem de 83 anos, HIV negativo, com derrame pleural à esquerda e ascite, observando ao exame citológico um líquido com predomínio de células mononucleares sem a presença de células malignas. Resultados: O paciente foi a óbito e a autópsia fez o diagnóstico de linfoma primário de derrames, observando também acometimento extracavitário multissistêmico. Conclusão: Embora o linfoma primário afete preferencialmente indivíduos HIV-positivos, a ausência de infecção pelo HIV não deve excluir a doença. O envolvimento extracavitário deve ser procurado mesmo em pacientes assintomáticos. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-12-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/32945 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. 4 (2021); 391-394 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. 4 (2021); 391-394 Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. 4 (2021); 391-394 1853-0605 0014-6722 10.31053/1853.0605.v78.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/32945/35635 https://revistas.unc.edu.ar/index.php/med/article/view/32945/36595 Derechos de autor 2021 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |