Use in the real world of Aspirin 100 mg in high risk pregnancies to prevent Preeclampsia.

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Objectives The objective of the present study was to analyse the use of 100 g aspirin dose as prevention method for preeclampsia in high risk pregnant patients. Methods A retrospective cohort study was performed in high risk pregnant patients with a blood pressure protocol, and the use of 100 mg of...

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Autores principales: Espeche, Walter Gaston, Minetto, Julian, Salazar, Martin Rogelio
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022
Materias:
preeclampsia
eclampsia
hypertension
pregnancy
aspirin
embarazo
hipertension
aspirina
Pré-eclâmpsia
Hipertensão
gravidez
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/32783
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-32783
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic preeclampsia
eclampsia
hypertension
pregnancy
aspirin
preeclampsia
eclampsia
embarazo
hipertension
aspirina
Pré-eclâmpsia
eclampsia
Hipertensão
gravidez
aspirina
spellingShingle preeclampsia
eclampsia
hypertension
pregnancy
aspirin
preeclampsia
eclampsia
embarazo
hipertension
aspirina
Pré-eclâmpsia
eclampsia
Hipertensão
gravidez
aspirina
Espeche, Walter Gaston
Minetto, Julian
Salazar, Martin Rogelio
Use in the real world of Aspirin 100 mg in high risk pregnancies to prevent Preeclampsia.
topic_facet preeclampsia
eclampsia
hypertension
pregnancy
aspirin
preeclampsia
eclampsia
embarazo
hipertension
aspirina
Pré-eclâmpsia
eclampsia
Hipertensão
gravidez
aspirina
author Espeche, Walter Gaston
Minetto, Julian
Salazar, Martin Rogelio
author_facet Espeche, Walter Gaston
Minetto, Julian
Salazar, Martin Rogelio
author_sort Espeche, Walter Gaston
title Use in the real world of Aspirin 100 mg in high risk pregnancies to prevent Preeclampsia.
title_short Use in the real world of Aspirin 100 mg in high risk pregnancies to prevent Preeclampsia.
title_full Use in the real world of Aspirin 100 mg in high risk pregnancies to prevent Preeclampsia.
title_fullStr Use in the real world of Aspirin 100 mg in high risk pregnancies to prevent Preeclampsia.
title_full_unstemmed Use in the real world of Aspirin 100 mg in high risk pregnancies to prevent Preeclampsia.
title_sort use in the real world of aspirin 100 mg in high risk pregnancies to prevent preeclampsia.
description Objectives The objective of the present study was to analyse the use of 100 g aspirin dose as prevention method for preeclampsia in high risk pregnant patients. Methods A retrospective cohort study was performed in high risk pregnant patients with a blood pressure protocol, and the use of 100 mg of aspirin vs. its non-use was evaluated in the incidence of PREEC.  Estimations between the two groups were performed with and without variable adjustment by means of binary logistic regression models. Results 633 high risk pregnant patients were evaluated. The average age was 30±7 years old, and 25±8 weeks of pregnancy. 281 women (44.3 %) within this group received aspirin. The total prevalence of PREEC in our sample was 151 pregnant women (23.8 %).Pregnant patients under the aspirin treatment developed less PREEC events (19.2% vs 27.5%, p=0.019); with OR not adjusted 0.62 (IC95% 0.43-0.91 p= 0.017). The risk was similar when it was adjusted by age, preeclampsia history, diabetes mellitus and chronic high blood pressure. (OR adjusted 0.63 IC95% 0.43-0.92 p= 0.017). Conclusions The use of 100 mg of aspirin a day before the 20th week of pregnancy in high risk pregnant patients decreased the risk of developing PREEC, regardless the age and risk factors.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2022
url https://revistas.unc.edu.ar/index.php/med/article/view/32783
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AT salazarmartinrogelio useintherealworldofaspirin100mginhighriskpregnanciestopreventpreeclampsia
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first_indexed 2022-08-20T01:27:50Z
last_indexed 2022-08-20T01:27:50Z
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spelling I10-R10-article-327832022-06-06T11:18:17Z Use in the real world of Aspirin 100 mg in high risk pregnancies to prevent Preeclampsia. Utilización de aspirina 100 mg/día para prevenir Preeclampsia, en embarazos de alto riego, en una cohorte de Argentina Uso de aspirina 100 mg / dia para prevenção da pré-eclâmpsia, em gestações de alto risco, em uma coorte da Argentina Espeche, Walter Gaston Minetto, Julian Salazar, Martin Rogelio preeclampsia eclampsia hypertension pregnancy aspirin preeclampsia eclampsia embarazo hipertension aspirina Pré-eclâmpsia eclampsia Hipertensão gravidez aspirina Objectives The objective of the present study was to analyse the use of 100 g aspirin dose as prevention method for preeclampsia in high risk pregnant patients. Methods A retrospective cohort study was performed in high risk pregnant patients with a blood pressure protocol, and the use of 100 mg of aspirin vs. its non-use was evaluated in the incidence of PREEC.  Estimations between the two groups were performed with and without variable adjustment by means of binary logistic regression models. Results 633 high risk pregnant patients were evaluated. The average age was 30±7 years old, and 25±8 weeks of pregnancy. 281 women (44.3 %) within this group received aspirin. The total prevalence of PREEC in our sample was 151 pregnant women (23.8 %).Pregnant patients under the aspirin treatment developed less PREEC events (19.2% vs 27.5%, p=0.019); with OR not adjusted 0.62 (IC95% 0.43-0.91 p= 0.017). The risk was similar when it was adjusted by age, preeclampsia history, diabetes mellitus and chronic high blood pressure. (OR adjusted 0.63 IC95% 0.43-0.92 p= 0.017). Conclusions The use of 100 mg of aspirin a day before the 20th week of pregnancy in high risk pregnant patients decreased the risk of developing PREEC, regardless the age and risk factors. Objetivos El objetivo de este estudio fue analizar la utilidad de la dosis de 100 mg de aspirina como medida de prevención para preeclampsia en pacientes embarazadas de alto riesgo. Métodos Se realizó un estudio de cohorte retrospectivo de embarazadas de alto riesgo en seguimiento con un protocolo de tensión arterial y se evaluó la utilización de aspirina 100 mg vs la no utilización de la misma, en la incidencia de PREEC. Se realizó estimaciones de riesgos entre ambos grupos sin y con ajuste de variables con modelos de regresión logística binaria. Resultados Fueron evaluadas 633 embarazadas de alto riesgo con promedio de 30±7 años y 25±8 semanas de gestación, de las cuales 281 mujeres (44,3%) recibieron aspirina. La prevalencia total de PREEC en nuestra muestra fue de 151 embarazadas (23,8%).Las embarazadas que estaban ingiriendo aspirina, desarrollaron menos eventos de PREEC (19.2% vs 27.5%, p=0.019); con OR no ajustado 0.62 (IC95% 0.43-0.91 p= 0.017). Siendo este riesgo similar cuando fue ajustado por edad, antecedentes de preeclampsia, diabetes mellitus e hipertensión arterial crónica. (OR ajustado 0.63 IC95% 0.43-0.92 p= 0.017). Conclusiones La utilización de Aspirina 100 mg por día antes de las 20 semanas de gestación en embarazadas de alto riesgo disminuyó el riesgo de desarrollar PREEC, independientemente de la edad y factores de riesgo. Metas O objetivo deste estudo foi analisar a utilidade da dose de 100 mg de aspirina como medida preventiva para pré-eclâmpsia em gestantes de alto risco. Métodos Realizou-se estudo de coorte retrospectivo de gestantes de alto risco em acompanhamento com protocolo de pressão arterial e avaliou-se o uso de aspirina 100 mg versus não uso na incidência de PREEC. As estimativas de risco foram feitas entre os dois grupos sem e com ajuste das variáveis ​​com modelos de regressão logística binária. Resultados Foram avaliadas 633 gestantes de alto risco com média de 30 ± 7 anos e 25 ± 8 semanas de gestação, sendo que 281 (44,3%) mulheres receberam aspirina. A prevalência total do PREEC em nossa amostra foi de 151 gestantes (23,8%). Mulheres grávidas que estavam tomando aspirina desenvolveram menos eventos PREEC (19,2% vs 27,5%, p = 0,019); com OR não ajustado 0,62 (IC 95% 0,43-0,91 p = 0,017). Esse risco é semelhante quando ajustado para idade, história de pré-eclâmpsia, diabetes mellitus e hipertensão arterial crônica. (OR ajustado 0,63 IC 95% 0,43-0,92 p = 0,017). Conclusões O uso de Aspirina 100 mg por dia antes da 20ª semana de gestação em gestantes de alto risco diminuiu o risco de desenvolver PREEC, independentemente da idade e dos fatores de risco. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-03-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/32783 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. 1 (2022); 4-9 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. 1 (2022); 4-9 Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. 1 (2022); 4-9 1853-0605 0014-6722 10.31053/1853.0605.v79.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/32783/37232 https://revistas.unc.edu.ar/index.php/med/article/view/32783/37020 Derechos de autor 2022 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0

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