Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients
Introduction: COVID-19 disease shows a marked heterogeneity in its clinical course, with descriptions of some factors associated with a worse prognosis. Knowledge of the disease behavior in the local scenario is relevant to allow a better approach. Methods: Retrospective study in...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/32518 |
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I10-R10-article-32518 |
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Universidad Nacional de Córdoba |
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Revistas de la UNC |
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Español |
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Artículo revista |
| topic |
coronavirus infections pneumonia inpatients prognosis betacoronavirus COVID-19 coronavirus SARS-CoV-2 hospitalized patients pneumonia infecciones por coronavirus neumonía pacientes internos pronóstico betacoronavirus COVID-19 coronavirus SARS-CoV-2 pacientes hospitalizados neumonía infecções por coronavirus pneumonia pacientes internados prognóstico betacoronavirus COVID-19 coronavírus SARS-CoV-2 pacientes hospitalizados pneumonia |
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coronavirus infections pneumonia inpatients prognosis betacoronavirus COVID-19 coronavirus SARS-CoV-2 hospitalized patients pneumonia infecciones por coronavirus neumonía pacientes internos pronóstico betacoronavirus COVID-19 coronavirus SARS-CoV-2 pacientes hospitalizados neumonía infecções por coronavirus pneumonia pacientes internados prognóstico betacoronavirus COVID-19 coronavírus SARS-CoV-2 pacientes hospitalizados pneumonia Saad, Emanuel José Correa Barovero, María Antonella Marucco , Federico Ariel Rodríguez Bonazzi, Silvina Trinidad Tarditi Barra, Ayelén Zlotogora, Melani Villada, Sofía María Douthat y Barrionuevo , Augusto Heredia, María Celeste Caeiro, Juan Pablo Fernández, Pehuén Albertini, Ricardo Arturo Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients |
| topic_facet |
coronavirus infections pneumonia inpatients prognosis betacoronavirus COVID-19 coronavirus SARS-CoV-2 hospitalized patients pneumonia infecciones por coronavirus neumonía pacientes internos pronóstico betacoronavirus COVID-19 coronavirus SARS-CoV-2 pacientes hospitalizados neumonía infecções por coronavirus pneumonia pacientes internados prognóstico betacoronavirus COVID-19 coronavírus SARS-CoV-2 pacientes hospitalizados pneumonia |
| author |
Saad, Emanuel José Correa Barovero, María Antonella Marucco , Federico Ariel Rodríguez Bonazzi, Silvina Trinidad Tarditi Barra, Ayelén Zlotogora, Melani Villada, Sofía María Douthat y Barrionuevo , Augusto Heredia, María Celeste Caeiro, Juan Pablo Fernández, Pehuén Albertini, Ricardo Arturo |
| author_facet |
Saad, Emanuel José Correa Barovero, María Antonella Marucco , Federico Ariel Rodríguez Bonazzi, Silvina Trinidad Tarditi Barra, Ayelén Zlotogora, Melani Villada, Sofía María Douthat y Barrionuevo , Augusto Heredia, María Celeste Caeiro, Juan Pablo Fernández, Pehuén Albertini, Ricardo Arturo |
| author_sort |
Saad, Emanuel José |
| title |
Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients |
| title_short |
Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients |
| title_full |
Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients |
| title_fullStr |
Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients |
| title_full_unstemmed |
Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients |
| title_sort |
clinical and epidemiological characteristics of patients hospitalized for sars-cov-2 infection in two hospitals in córdoba: sars-cov-2 infection in hospitalized patients |
| description |
Introduction: COVID-19 disease shows a marked heterogeneity in its clinical course, with descriptions of some factors associated with a worse prognosis. Knowledge of the disease behavior in the local scenario is relevant to allow a better approach.
Methods: Retrospective study in two hospitals in the city of Córdoba, Argentina, with patients aged 18 years or more, hospitalized for active SARS-CoV-2 infection, from March to October, 2020.
Results: 448 patients were included, of which 95.75% corresponded to COVID-19 pneumonia. Most of the episodes occurred in men (63.6%), the median age was 63 years (IQR: 53-75), and the most frequent comorbidities were arterial hypertension (55.1%), obesity (31.7%) and diabetes mellitus (28.1%). 162 patients (36.2%) needed admission to the intensive care unit and 66 (14.7%) were placed on mechanical ventilation. 67 patients (15%) died within the first 30 days of follow-up. In the multivariate analysis, the only independent variable predictive of mortality at 30 days was age (adjusted Odds ratio [aOR] = 1.08, 95% CI = 1.04-1.11, p <0.001). The 4C-Score and CALL-Score prognostic scores showed good discrimination (Area under the curve [AUC] = 0.766, 95% CI = 0.72-0.80 and AUC = 0.785, 95% CI = 0.70-0.85 respectively) and the predicted percentages of mortality were quite close to what was observed in the present study.
Conclusions: Most of the patients hospitalized with SARS-CoV-2 infection presented comorbidities and were admitted with pneumonia, associated with high mortality. The prognostic scores with the best performance to predict complications were the 4C-score and the CALL-score. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/32518 |
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I10-R10-article-325182021-11-18T12:43:09Z Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients Características clínicas y epidemiológicas de pacientes hospitalizados por infección por SARS-CoV-2 en dos hospitales en Córdoba: Infección por SARS-CoV-2 en pacientes hospitalizados Características clínicas e epidemiológicas de pacientes internados por infecção por SARS-CoV-2 em dois hospitais de Córdoba: Infecção por SARS-CoV-2 em pacientes hospitalizados Saad, Emanuel José Correa Barovero, María Antonella Marucco , Federico Ariel Rodríguez Bonazzi, Silvina Trinidad Tarditi Barra, Ayelén Zlotogora, Melani Villada, Sofía María Douthat y Barrionuevo , Augusto Heredia, María Celeste Caeiro, Juan Pablo Fernández, Pehuén Albertini, Ricardo Arturo coronavirus infections pneumonia inpatients prognosis betacoronavirus COVID-19 coronavirus SARS-CoV-2 hospitalized patients pneumonia infecciones por coronavirus neumonía pacientes internos pronóstico betacoronavirus COVID-19 coronavirus SARS-CoV-2 pacientes hospitalizados neumonía infecções por coronavirus pneumonia pacientes internados prognóstico betacoronavirus COVID-19 coronavírus SARS-CoV-2 pacientes hospitalizados pneumonia Introduction: COVID-19 disease shows a marked heterogeneity in its clinical course, with descriptions of some factors associated with a worse prognosis. Knowledge of the disease behavior in the local scenario is relevant to allow a better approach. Methods: Retrospective study in two hospitals in the city of Córdoba, Argentina, with patients aged 18 years or more, hospitalized for active SARS-CoV-2 infection, from March to October, 2020. Results: 448 patients were included, of which 95.75% corresponded to COVID-19 pneumonia. Most of the episodes occurred in men (63.6%), the median age was 63 years (IQR: 53-75), and the most frequent comorbidities were arterial hypertension (55.1%), obesity (31.7%) and diabetes mellitus (28.1%). 162 patients (36.2%) needed admission to the intensive care unit and 66 (14.7%) were placed on mechanical ventilation. 67 patients (15%) died within the first 30 days of follow-up. In the multivariate analysis, the only independent variable predictive of mortality at 30 days was age (adjusted Odds ratio [aOR] = 1.08, 95% CI = 1.04-1.11, p <0.001). The 4C-Score and CALL-Score prognostic scores showed good discrimination (Area under the curve [AUC] = 0.766, 95% CI = 0.72-0.80 and AUC = 0.785, 95% CI = 0.70-0.85 respectively) and the predicted percentages of mortality were quite close to what was observed in the present study. Conclusions: Most of the patients hospitalized with SARS-CoV-2 infection presented comorbidities and were admitted with pneumonia, associated with high mortality. The prognostic scores with the best performance to predict complications were the 4C-score and the CALL-score. Introducción: La enfermedad COVID-19 muestra una marcada heterogeneidad en su curso clínico, habiéndose descripto algunos factores que se asocian un peor pronóstico. El conocimiento del comportamiento de la enfermedad en el escenario local es de gran relevancia para permitir un mejor abordaje. Métodos: Estudio retrospectivo en dos hospitales de la ciudad de Córdoba, Argentina, de pacientes de 18 años o más hospitalizados por infección activa por SARS-CoV-2, desde marzo a octubre del año 2020. Resultados: Se incluyeron 448 pacientes, de los cuales el 95.75% correspondieron a neumonía COVID-19. La mayoría de los episodios ocurrieron en hombres (63.6%), la mediana de edad fue 63 años (RIC:53-75), y las comorbilidades más frecuentes fueron hipertensión arterial (55.1%), obesidad (31.7%) y diabetes mellitus (28.1%). Requirieron ingreso a unidad de cuidados intensivos 162 pacientes (36.2%) y 66 (14.7%), asistencia respiratoria mecánica. Fallecieron 67 pacientes (15%) dentro de los primeros 30 días de seguimiento. En el análisis multivariado la única variable independiente predictora de mortalidad a los 30 días fue la edad (Odds ratio ajustado [ORa]=1.08, IC95%=1.04-1.11, p<0.001). Los scores pronósticos 4C-Score y CALL-Score presentaron muy buena discriminación (Área bajo la curva [ABC]=0.766, IC95%=0.72-0.80 y ABC=0.785, IC95%=0.70-0.85, respectivamente) y los porcentajes predichos de mortalidad se aproximaron bastante a lo observado en el presente estudio. Conclusiones: La mayoría de los pacientes hospitalizados por infección por SARS-CoV-2 presentaban comorbilidades y se presentaron como neumonía, asociada a una elevada mortalidad. Los scores pronósticos con mejor rendimiento para predecir complicaciones fueron el 4C-Score y el CALL score. Introdução: A doença COVID-19 apresenta uma acentuada heterogeneidade em seu curso clínico, sendo descritos alguns fatores associados a um pior prognóstico. O conhecimento do comportamento da doença no cenário local é de grande relevância para permitir uma melhor abordagem. Métodos: Estudo retrospectivo em dois hospitais da cidade de Córdoba, Argentina, de pacientes com 18 anos ou mais internados por infecção ativa de SARS-CoV-2, de março a outubro de 2020. Resultados: foram incluídos 448 pacientes, dos quais 95,75% correspondiam a pneumonia COVID-19. A maioria dos episódios ocorreu em homens (63,6%), a mediana de idade foi de 63 anos (IQR: 53-75) e as comorbidades mais frequentes foram hipertensão arterial (55,1%), obesidade (31,7%) e diabetes mellitus (28,1%) ) 162 pacientes (36,2%) e 66 (14,7%) em ventilação mecânica necessitaram de internação em unidade de terapia intensiva. 67 (15%) pacientes morreram nos primeiros 30 dias de acompanhamento. Na análise multivariada, a única variável independente preditiva de mortalidade em 30 dias foi a idade (Odds ratio ajustada [ORa] = 1,08, IC 95% = 1,04-1,11, p <0,001). Os escores prognósticos 4C-Score e CALL-Score apresentaram discriminação muito boa (Área abaixo da curva [ABC] = 0,766, IC 95% = 0,72-0,80 e ABC = 0,785, IC 95% = 0,70-0,85 respectivamente) e os percentuais previstos de mortalidade foram bastante próximos ao observado no presente estudo. Conclusões: A maioria dos pacientes internados por infecção por SARS-CoV-2 apresentava comorbidades e se apresentava como pneumonia, associada a alta mortalidade. Os escores prognósticos com melhor desempenho para predizer complicações foram o 4C-score e CALL-score. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-09-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/32518 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. 3 (2021); 303-312 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. 3 (2021); 303-312 Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. 3 (2021); 303-312 1853-0605 0014-6722 10.31053/1853.0605.v78.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/32518/35231 https://revistas.unc.edu.ar/index.php/med/article/view/32518/35285 Derechos de autor 2021 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |