Characterization of the problem of the therapeutic use of Cannabis Oil in Córdoba, Argentina
The therapeutic use of “cannabis” oil is a social problem that puts legal, health, scientific and cultural aspects under stress. The difficulty in access generates an emptiness than is exploited by illegal market, to which patients and relatives resort to improve their health and quality of life. Th...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/30922 |
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I10-R10-article-30922 |
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ojs |
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Universidad Nacional de Córdoba |
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Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
dronabinol cannabidiol cannabinoids (therapeutic use) dronabinol cannabidiol cannabinoides (uso terapéutico) dronabinol canabidiol canabinoides (uso terapéutico) |
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dronabinol cannabidiol cannabinoids (therapeutic use) dronabinol cannabidiol cannabinoides (uso terapéutico) dronabinol canabidiol canabinoides (uso terapéutico) Manzo, Pablo Gabriel Martín, Sandra Uema, Sonia Charles, Germán Montero Bruni, Felipe Núñez Montoya, Susana Bertotto , María Eugenia Eynard , Martín Armando, Pedro Bustos Fierro, Carolina Characterization of the problem of the therapeutic use of Cannabis Oil in Córdoba, Argentina |
| topic_facet |
dronabinol cannabidiol cannabinoids (therapeutic use) dronabinol cannabidiol cannabinoides (uso terapéutico) dronabinol canabidiol canabinoides (uso terapéutico) |
| author |
Manzo, Pablo Gabriel Martín, Sandra Uema, Sonia Charles, Germán Montero Bruni, Felipe Núñez Montoya, Susana Bertotto , María Eugenia Eynard , Martín Armando, Pedro Bustos Fierro, Carolina |
| author_facet |
Manzo, Pablo Gabriel Martín, Sandra Uema, Sonia Charles, Germán Montero Bruni, Felipe Núñez Montoya, Susana Bertotto , María Eugenia Eynard , Martín Armando, Pedro Bustos Fierro, Carolina |
| author_sort |
Manzo, Pablo Gabriel |
| title |
Characterization of the problem of the therapeutic use of Cannabis Oil in Córdoba, Argentina |
| title_short |
Characterization of the problem of the therapeutic use of Cannabis Oil in Córdoba, Argentina |
| title_full |
Characterization of the problem of the therapeutic use of Cannabis Oil in Córdoba, Argentina |
| title_fullStr |
Characterization of the problem of the therapeutic use of Cannabis Oil in Córdoba, Argentina |
| title_full_unstemmed |
Characterization of the problem of the therapeutic use of Cannabis Oil in Córdoba, Argentina |
| title_sort |
characterization of the problem of the therapeutic use of cannabis oil in córdoba, argentina |
| description |
The therapeutic use of “cannabis” oil is a social problem that puts legal, health, scientific and cultural aspects under stress. The difficulty in access generates an emptiness than is exploited by illegal market, to which patients and relatives resort to improve their health and quality of life. These oils, with unknown chemical composition, are used without a therapeutic follow-up. An interdisciplinary team from the UNC got involved in this problem with the aim of proving elements for its characterization in our environment. Methodology: Observational-descriptive and cross-sectional study (approved by CIEIS-HNC-UNC): interviews with patients/caregivers of legal age who were using “cannabis” oil (2019). Experimental study: analysis of oil samples obtained from interviewees to determine their cannabinoids content (THC and CBD), by means of HPLC technique. Results: thirty-seven interviews were conducted, and 48 samples were analysed. The 73% were adults and older adults. The 79% started using the oil on the recommendation of relatives/friends or on their self-initiative, mainly due to the lack of effectiveness of other therapies (54%) and searching for alternatives (33%). The 84% perceived it effective (moderate to highly effective), and 78% did not report adverse events. Main uses: refractory epilepsy 27% and arthritis/arthrosis 24%. Fifteen percent of the samples did not show any quantifiable content of CBD nor THC, and 67% had only THC. The quantifiable contents of cannabinoids were very low. Conclusions: an approach to therapeutic use of “cannabis” oil in Córdoba and its quality were obtained. Discrepancy between the perceived effectiveness and the low content of cannabinoids detected was observed. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/30922 |
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I10-R10-article-309222022-08-19T21:47:05Z Characterization of the problem of the therapeutic use of Cannabis Oil in Córdoba, Argentina Caracterización de la problemática del uso terapéutico del Aceite de Cannabis en Córdoba, Argentina Caracterização do problema do uso terapêutico do óleo de cannabis em Córdoba, Argentina Manzo, Pablo Gabriel Martín, Sandra Uema, Sonia Charles, Germán Montero Bruni, Felipe Núñez Montoya, Susana Bertotto , María Eugenia Eynard , Martín Armando, Pedro Bustos Fierro, Carolina dronabinol cannabidiol cannabinoids (therapeutic use) dronabinol cannabidiol cannabinoides (uso terapéutico) dronabinol canabidiol canabinoides (uso terapéutico) The therapeutic use of “cannabis” oil is a social problem that puts legal, health, scientific and cultural aspects under stress. The difficulty in access generates an emptiness than is exploited by illegal market, to which patients and relatives resort to improve their health and quality of life. These oils, with unknown chemical composition, are used without a therapeutic follow-up. An interdisciplinary team from the UNC got involved in this problem with the aim of proving elements for its characterization in our environment. Methodology: Observational-descriptive and cross-sectional study (approved by CIEIS-HNC-UNC): interviews with patients/caregivers of legal age who were using “cannabis” oil (2019). Experimental study: analysis of oil samples obtained from interviewees to determine their cannabinoids content (THC and CBD), by means of HPLC technique. Results: thirty-seven interviews were conducted, and 48 samples were analysed. The 73% were adults and older adults. The 79% started using the oil on the recommendation of relatives/friends or on their self-initiative, mainly due to the lack of effectiveness of other therapies (54%) and searching for alternatives (33%). The 84% perceived it effective (moderate to highly effective), and 78% did not report adverse events. Main uses: refractory epilepsy 27% and arthritis/arthrosis 24%. Fifteen percent of the samples did not show any quantifiable content of CBD nor THC, and 67% had only THC. The quantifiable contents of cannabinoids were very low. Conclusions: an approach to therapeutic use of “cannabis” oil in Córdoba and its quality were obtained. Discrepancy between the perceived effectiveness and the low content of cannabinoids detected was observed. El uso terapéutico del aceite de “cannabis” es una problemática social que pone en tensión aspectos legales, sanitarios, científicos y culturales. La dificultad en el acceso genera un vacío aprovechado por el mercado ilegal, al que recurren pacientes y familiares para mejorar su salud y calidad de vida. Estos aceites, de composición química desconocida, se emplean sin un seguimiento terapéutico. Un equipo interdisciplinario de la UNC se involucró en esta problemática con el objetivo de aportar elementos para su caracterización en nuestro medio. Metodología: Estudio observacional-descriptivo y transversal (aprobado por el CIEIS-HNC-UNC): entrevistas a pacientes/cuidadores mayores de edad que usaban el aceite (2019). Estudio experimental: análisis de muestras de aceites de los entrevistados para determinar su contenido de cannabinoides (THC y CBD), mediante HPLC. Resultados: Se realizaron 37 entrevistas y analizaron 48 muestras. El 73% fueron adultos y adultos-mayores. El 79% empiezan a usar el aceite por recomendación de parientes/amigos o por iniciativa propia, principalmente por falta de efectividad de otras terapias (54%) y por búsqueda de alternativas (33%). El 84% lo percibe efectivo (moderado-muy efectivo) y el 78% no manifestó eventos adversos. Usos principales: epilepsia refractaria 27% y artritis/artrosis 24%. El 15% de las muestras no presentaron contenidos cuantificables de CBD y THC, y el 67% presentó THC sin CBD. El contenido de cannabinoides cuantificables fue muy bajo. Conclusiones: Se obtuvo una aproximación sobre el uso terapéutico del aceite de “cannabis” en Córdoba y su calidad. Se observó discrepancia entre la efectividad percibida y el bajo contenido de cannabinoides detectados. O uso terapêutico do óleo de “cannabis” é um problema social que coloca em questão os aspectos jurídicos, de saúde, científicos e culturais. A dificuldade de acesso gera um vazio que não é explorado pelo mercado ilegal, ao qual pacientes e familiares recorrem para melhorar sua saúde e qualidade de vida. Esses óleos, de composição química desconhecida, são utilizados sem acompanhamento terapêutico. Uma equipe interdisciplinar da UNC se envolveu neste problema com o objetivo de fornecer elementos para sua caracterização em nosso meio. Metodologia: Estudo observacional-descritivo e transversal (aprovado pelo CIEIS-HNC-UNC): entrevistas com pacientes / cuidadores maiores de idade que faziam uso de óleo de “cannabis” (2019). Estudo experimental: análise de amostras de óleo obtidas dos entrevistados para determinação do teor de canabinóides (THC e CBD), por meio da técnica de HPLC. Resultados: foram realizadas trinta e sete entrevistas e analisadas 48 amostras. Os 73% eram adultos e idosos. Os 79% começaram a usar o óleo por indicação de parentes / amigos ou por iniciativa própria, principalmente devido à falta de eficácia de outras terapias (54%) e na busca de alternativas (33%). Os 84% perceberam que é eficaz (moderado a altamente eficaz) e 78% não relataram eventos adversos. Principais utilizações: epilepsia refratária 27% e artrite / artrose 24%. Quinze por cento das amostras não apresentaram qualquer conteúdo quantificável de CBD ou THC, e 67% tinham apenas THC. Os conteúdos quantificáveis de canabinóides eram muito baixos. Conclusões: foi obtida uma abordagem para o uso terapêutico do óleo de “cannabis” em Córdoba e sua qualidade. Foi observada discrepância entre a eficácia percebida e o baixo teor de canabinóides detectados. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-06-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/30922 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. 2 (2022); 123-131 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. 2 (2022); 123-131 Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. 2 (2022); 123-131 1853-0605 0014-6722 10.31053/1853.0605.v79.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/30922/37665 https://revistas.unc.edu.ar/index.php/med/article/view/30922/37535 Derechos de autor 2022 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |