Evaluation of the INTERGROWTH-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality
Introduction The use of local references or standard for neonatal studies still requires their validation through indicators of morbidity and mortality. Objective: evaluate the performance of the INTERGROWTH-21st Project (IG-21) standard and a commonly used Argentinian reference (Urquia) by examinin...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2020
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/28064 |
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I10-R10-article-28064 |
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ojs |
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Universidad Nacional de Córdoba |
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I-10 |
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R-10 |
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Revistas de la UNC |
| language |
Inglés |
| format |
Artículo revista |
| topic |
fetal nutrition disorders stature by age body mass index morbidity infant mortality trastornos nutricionales en el feto estatura por edad índice de masa corporal morbilidad mortalidad infantil transtornos da nutrição fetal estatura-idade índice de massa corporal morbidade mortalidade infantil |
| spellingShingle |
fetal nutrition disorders stature by age body mass index morbidity infant mortality trastornos nutricionales en el feto estatura por edad índice de masa corporal morbilidad mortalidad infantil transtornos da nutrição fetal estatura-idade índice de massa corporal morbidade mortalidade infantil Grandi, Carlos del Pino, Mariana Casale Aragon, Davi dos Santos Rodrigues, Livia Cunha Cardoso, Viviane Evaluation of the INTERGROWTH-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality |
| topic_facet |
fetal nutrition disorders stature by age body mass index morbidity infant mortality trastornos nutricionales en el feto estatura por edad índice de masa corporal morbilidad mortalidad infantil transtornos da nutrição fetal estatura-idade índice de massa corporal morbidade mortalidade infantil |
| author |
Grandi, Carlos del Pino, Mariana Casale Aragon, Davi dos Santos Rodrigues, Livia Cunha Cardoso, Viviane |
| author_facet |
Grandi, Carlos del Pino, Mariana Casale Aragon, Davi dos Santos Rodrigues, Livia Cunha Cardoso, Viviane |
| author_sort |
Grandi, Carlos |
| title |
Evaluation of the INTERGROWTH-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality |
| title_short |
Evaluation of the INTERGROWTH-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality |
| title_full |
Evaluation of the INTERGROWTH-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality |
| title_fullStr |
Evaluation of the INTERGROWTH-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality |
| title_full_unstemmed |
Evaluation of the INTERGROWTH-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality |
| title_sort |
evaluation of the intergrowth-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality |
| description |
Introduction
The use of local references or standard for neonatal studies still requires their validation through indicators of morbidity and mortality. Objective: evaluate the performance of the INTERGROWTH-21st Project (IG-21) standard and a commonly used Argentinian reference (Urquia) by examining the differences in the frequency of growth phenotypes, and the associated neonatal morbidity and mortality.
Methods: Retrospective cohort study of all singleton live-births from Sarda Maternity Hospital (Buenos Aires, Argentina) between 33 and 42 gestational age, using information obtained from a Perinatal Surveillance System (Agustina) dataset between 1996-2001 (n = 25948). Phenotypes small- and large-for-gestational age, stunting and waisting and a composite of neonatal morbidity/mortality (CNMM) were contrasted between the IG-21 standard and Urquia reference.
Results: the Urquia 3rd centile value was lower than IG-21 before 37 weeks, but then it surpassed IG-21 until term. Among Sarda , 2.3%, 5.9% and 8.9 were <3rd, <10th and >97th centile, respectively, under the IG-21 standard, while 3.7%, 10.1% and 8.4% were <3rd, <10th and >97th centile, respectively, under the Urquia reference. Stunting and waisting were 16.1% and 0.9%, respectively under IG-21. The IG-21 detection rates of CNMM showed that 28.5%, 19.6% and 8.5% occurred among weight<3rd,<10th and >97th centile, respectively, while 21.8%, 14.2% and 8.0% occurred among <3rd, <10th and >97th centile under the Urquia criteria. Newborn weight <3rd,<10th and >97th centile under IG-21 showed higher neonatal CNMM risk compared with Urquia reference.
Conclusions: The IG-21 standard identified a higher risk of neonatal morbidity and mortality than the Urquia reference. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2020 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/28064 |
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I10-R10-article-280642020-06-19T15:10:07Z Evaluation of the INTERGROWTH-21st project newborn standard for neonatal phenotypes and neonatal morbidity and mortality Evaluación de fenotipos nutricionales del recién nacido con el estándar INTERGROWTH-21st para predicción de morbilidad y mortalidad neonatales Avaliação de fenótipos nutricionais do recém-nascido com o padrão INTERGROWTH-21st para predição de morbimortalidade neonatal Grandi, Carlos del Pino, Mariana Casale Aragon, Davi dos Santos Rodrigues, Livia Cunha Cardoso, Viviane fetal nutrition disorders stature by age body mass index morbidity infant mortality trastornos nutricionales en el feto estatura por edad índice de masa corporal morbilidad mortalidad infantil transtornos da nutrição fetal estatura-idade índice de massa corporal morbidade mortalidade infantil Introduction The use of local references or standard for neonatal studies still requires their validation through indicators of morbidity and mortality. Objective: evaluate the performance of the INTERGROWTH-21st Project (IG-21) standard and a commonly used Argentinian reference (Urquia) by examining the differences in the frequency of growth phenotypes, and the associated neonatal morbidity and mortality. Methods: Retrospective cohort study of all singleton live-births from Sarda Maternity Hospital (Buenos Aires, Argentina) between 33 and 42 gestational age, using information obtained from a Perinatal Surveillance System (Agustina) dataset between 1996-2001 (n = 25948). Phenotypes small- and large-for-gestational age, stunting and waisting and a composite of neonatal morbidity/mortality (CNMM) were contrasted between the IG-21 standard and Urquia reference. Results: the Urquia 3rd centile value was lower than IG-21 before 37 weeks, but then it surpassed IG-21 until term. Among Sarda , 2.3%, 5.9% and 8.9 were <3rd, <10th and >97th centile, respectively, under the IG-21 standard, while 3.7%, 10.1% and 8.4% were <3rd, <10th and >97th centile, respectively, under the Urquia reference. Stunting and waisting were 16.1% and 0.9%, respectively under IG-21. The IG-21 detection rates of CNMM showed that 28.5%, 19.6% and 8.5% occurred among weight<3rd,<10th and >97th centile, respectively, while 21.8%, 14.2% and 8.0% occurred among <3rd, <10th and >97th centile under the Urquia criteria. Newborn weight <3rd,<10th and >97th centile under IG-21 showed higher neonatal CNMM risk compared with Urquia reference. Conclusions: The IG-21 standard identified a higher risk of neonatal morbidity and mortality than the Urquia reference. Introducción: El uso de referencias locales o estándares para estudios neonatales aún requiere su validación a través de indicadores de morbilidad y mortalidad. Objetivo: Comparar la capacidad predictiva del estándar INTERGROWTH-21st (IG-21st) y una referencia argentina (Urquia) mediante los fenotipos de crecimiento fetal y morbi-mortalidad neonatales. Métodos: Estudio de cohorte retrospectivo de recién nacidos vivos entre 33 y 42 semanas del Hospital Materno-Infantil Ramón Sarda (Buenos Aires, Argentina), entre 1996-2001 (n = 25948). Los fenotipos pequeños (PEG) y grandes para la edad gestacional, acortado y emaciado y un índice compuesto de morbilidad / mortalidad neonatal (CNMM) se contrastaron entre IG-21st y la referencia Urquia. Resultados: El 3er percentil del peso al nacer de Urquia fue menor que el de IG-21st antes de las 37 semanas; 2.3%, 5.9% y 8.9 de los RN fueron <3o, <10° y > 97° percentil, respectivamente, bajo el estándar IG-21st, mientras que 3,7%, 10,1% y 8,4% fueron <3 °, <10 ° y> 97 ° percentil, respectivamente, bajo la referencia Urquia. Acortados fueron 16.1% y emaciados 0.9%, bajo IG-21st. CNMM bajo IG-21st fueron 28.5%, 19.6% y 8.5% en peso<3o, <10º y >97º percentil, respectivamente, mientras que 21.8%, 14.2% y 8.0% ocurrieron en peso< 3°, <10° y > 97° percentil bajo Urquia. Acortados fueron 17.3% y emaciados 18.3%. Los RN <3er°, <10° y > 97° percentil bajo IG-21st mostraron mayor riesgo de CNMM en comparación con la referencia Urquia. Conclusiones: El estándar IG-21st identificó mayor riesgo de morbilidad y mortalidad que la referencia Urquia. Introdução: O uso de referências locais ou padrões para estudos neonatais ainda exige validação por meio de indicadores de morbimortalidade. Objetivo: Comparar a capacidade preditiva do padrão INTERGROWTH-21st (IG-21st) e uma referência argentina (Urquia) examinando as diferenças nos fenótipos de crescimento fetal neonatal e morbimortalidade. Métodos: Estudo de coorte retrospectivo de recém-nascidos vivos (RNV) entre 33 e 42 semanas do Hospital Materno Infantil Ramón Sarda (Buenos Aires, Argentina), entre 1996-2001 (n = 25948). Fenótipos pequeno (PEG) e grande para idade gestacional, encurtado e emaciado e um índice composto de morbimortalidade neonatal (CNMM) foram contrastados entre o IG-21st e a referência de Urquia. Resultados: o 3º percentil do peso ao nascer de Urquia foi inferior ao do IG-21st antes de 37 semanas; 2,3%, 5,9% e 8,9 dos RNV apresentaram percentil <3, <10 e> 97, respectivamente, segundo o padrão IG-21st, enquanto 3,7%, 10,1% e 8,4% foram < percentil 3, <10 e> 97, respectivamente, sob a referência Urquia. Encurtados foram 17,3% e emaciados 18,3% sob IG-21st. Os RNV <3º, <10º e> 97º percentil no IG-21st apresentaram maior risco de CNMM em comparação com a referência Urquia. Conclusões: O padrão IG-21st identificou um risco maior de morbimortalidade do que a referência Urquia. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020-05-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/28064 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 77 No. 2 (2020); 86-93 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 77 Núm. 2 (2020); 86-93 Revista da Faculdade de Ciências Médicas de Córdoba; v. 77 n. 2 (2020); 86-93 1853-0605 0014-6722 10.31053/1853.0605.v77.n2 eng https://revistas.unc.edu.ar/index.php/med/article/view/28064/29617 https://revistas.unc.edu.ar/index.php/med/article/view/28064/29868 Derechos de autor 2020 Universidad Nacional de Córdoba |