Molecular aspects of antineoplasic action of vitamin D

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The effects of the environment, particularly dietary factors, may influence in the development and prevention of cancer. Vitamin D (colecalciferol) has been associated for years with calcium homeostasis regulation, but many epidemiological, biochemical and genetic studies reveal non classic effects...

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Autores principales:	Bohl, Luciana Paola, Liaudat, Ana Cecilia, Picotto, Gabriela, Tolosa de Talamoni, Nori Graciela
Formato:	Artículo revista
Lenguaje:	Español
Publicado:	Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020
Materias:	cancer calcitriol molecular mechanisms antineoplasic effects cáncer mecanismos moleculares efectos antineoplásicos
Acceso en línea:	https://revistas.unc.edu.ar/index.php/med/article/view/27686
Aporte de:	Revistas de la UNC de Universidad Nacional de Córdoba

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spelling	I10-R10-article-276862020-03-05T18:50:29Z Molecular aspects of antineoplasic action of vitamin D Aspectos moleculares de la acción antineoplásica de la vitamina D Bohl, Luciana Paola Liaudat, Ana Cecilia Picotto, Gabriela Tolosa de Talamoni, Nori Graciela cancer calcitriol molecular mechanisms antineoplasic effects cáncer calcitriol mecanismos moleculares efectos antineoplásicos The effects of the environment, particularly dietary factors, may influence in the development and prevention of cancer. Vitamin D (colecalciferol) has been associated for years with calcium homeostasis regulation, but many epidemiological, biochemical and genetic studies reveal non classic effects of vitamin D, such as vitamin D involvement in the progression of different types of cancer. The aim of the present article was to give a review about the molecular mechanisms of the antineoplasic action of vitamin D. These effects are still not completely established, but it is well known that vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis and alters cellular adhesion. To maintain suitable vitamin D levels seems to be necessary for many physiological processes, and not only for bone homeostasis. Clinical studies might determine vitamin D levels that can also protect against the cancer development Los factores ambientales, en particular los dietarios, pueden influir en el desarrollo y la prevención del cáncer. La vitamina D (colecalciferol) ha sido por años asociada a la regulación de la homeostasis de calcio pero existen numerosos estudios epidemiológicos, bioquímicos y genéticos sobre otros efectos no clásicos de la vitamina D, como el desarrollo y la progresión de diferentes cánceres. El objetivo del presente artículo es brindar una revisión sobre los mecanismos moleculares de la acción antineoplásica de la vitamina D. Estos efectos no están completamente establecidos pero se sabe que la vitamina D induce el arresto del ciclo celular, desencadena vías apoptóticas, inhibe la angiogénesis y altera la adhesión celular. Mantener niveles adecuados de vitamina D son necesarios para una gran cantidad de procesos fisiológicos y no solamente para el mantenimiento de la homeostasis del hueso. Los estudios clínicos podrían determinar niveles de vitamina D que puedan proteger también contra el desarrollo del cáncer. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020-02-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/27686 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 65 No. 1 (2008); 16 - 21 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 65 Núm. 1 (2008); 16 - 21 Revista da Faculdade de Ciências Médicas de Córdoba; v. 65 n. 1 (2008); 16 - 21 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/27686/29113 Derechos de autor 2020 Universidad Nacional de Córdoba
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-10
container_title_str	Revistas de la UNC
language	Español
format	Artículo revista
topic	cancer calcitriol molecular mechanisms antineoplasic effects cáncer calcitriol mecanismos moleculares efectos antineoplásicos
spellingShingle	cancer calcitriol molecular mechanisms antineoplasic effects cáncer calcitriol mecanismos moleculares efectos antineoplásicos Bohl, Luciana Paola Liaudat, Ana Cecilia Picotto, Gabriela Tolosa de Talamoni, Nori Graciela Molecular aspects of antineoplasic action of vitamin D
topic_facet	cancer calcitriol molecular mechanisms antineoplasic effects cáncer calcitriol mecanismos moleculares efectos antineoplásicos
author	Bohl, Luciana Paola Liaudat, Ana Cecilia Picotto, Gabriela Tolosa de Talamoni, Nori Graciela
author_facet	Bohl, Luciana Paola Liaudat, Ana Cecilia Picotto, Gabriela Tolosa de Talamoni, Nori Graciela
author_sort	Bohl, Luciana Paola
title	Molecular aspects of antineoplasic action of vitamin D
title_short	Molecular aspects of antineoplasic action of vitamin D
title_full	Molecular aspects of antineoplasic action of vitamin D
title_fullStr	Molecular aspects of antineoplasic action of vitamin D
title_full_unstemmed	Molecular aspects of antineoplasic action of vitamin D
title_sort	molecular aspects of antineoplasic action of vitamin d
description	The effects of the environment, particularly dietary factors, may influence in the development and prevention of cancer. Vitamin D (colecalciferol) has been associated for years with calcium homeostasis regulation, but many epidemiological, biochemical and genetic studies reveal non classic effects of vitamin D, such as vitamin D involvement in the progression of different types of cancer. The aim of the present article was to give a review about the molecular mechanisms of the antineoplasic action of vitamin D. These effects are still not completely established, but it is well known that vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis and alters cellular adhesion. To maintain suitable vitamin D levels seems to be necessary for many physiological processes, and not only for bone homeostasis. Clinical studies might determine vitamin D levels that can also protect against the cancer development
publisher	Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate	2020
url	https://revistas.unc.edu.ar/index.php/med/article/view/27686
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first_indexed	2022-08-20T01:27:16Z
last_indexed	2022-08-20T01:27:16Z
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Molecular aspects of antineoplasic action of vitamin D

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