Mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort
INTRODUCTION: Venous thromboembolic disease (VTE) is a pathology that increases with age. OBJECTIVE: to compare the survival of the elderly and the young with a first episode of acute and symptomatic VTE. MATERIALS AND METHODS: Prospective cohort of incident VTE cases included in the Institutional R...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2020
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/27135 |
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I10-R10-article-27135 |
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Universidad Nacional de Córdoba |
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I-10 |
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Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
tromboembolia tromboembolia venosa anciano español english portugues |
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tromboembolia tromboembolia venosa anciano español english portugues Posadas-Martinez, Maria Lourdes Pagotto, Vanina Laura Grande Ratti, Maria Florencia Alfie, Veronica Andresik, Diego Torres Gomez, Felipe Giunta, Diego Hernan Luxardo, Rosario Scolnik, Marina Vazquez, Fernando Javier Mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort |
| topic_facet |
tromboembolia tromboembolia venosa anciano español english portugues |
| author |
Posadas-Martinez, Maria Lourdes Pagotto, Vanina Laura Grande Ratti, Maria Florencia Alfie, Veronica Andresik, Diego Torres Gomez, Felipe Giunta, Diego Hernan Luxardo, Rosario Scolnik, Marina Vazquez, Fernando Javier |
| author_facet |
Posadas-Martinez, Maria Lourdes Pagotto, Vanina Laura Grande Ratti, Maria Florencia Alfie, Veronica Andresik, Diego Torres Gomez, Felipe Giunta, Diego Hernan Luxardo, Rosario Scolnik, Marina Vazquez, Fernando Javier |
| author_sort |
Posadas-Martinez, Maria Lourdes |
| title |
Mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort |
| title_short |
Mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort |
| title_full |
Mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort |
| title_fullStr |
Mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort |
| title_full_unstemmed |
Mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort |
| title_sort |
mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort |
| description |
INTRODUCTION: Venous thromboembolic disease (VTE) is a pathology that increases with age. OBJECTIVE: to compare the survival of the elderly and the young with a first episode of acute and symptomatic VTE. MATERIALS AND METHODS: Prospective cohort of incident VTE cases included in the Institutional Registry of Venous Thromboembolic Disease (NCT01372514) of the Italian Hospital of Buenos Aires between 2012-2014, divided into young groups (17-64 years old) and elderly (65 years old). All the patients were followed annually to assess the time to recurrence (progression or new symptomatic event of VTE) as competitive events in the context of death and major bleeding. Raw (c) and adjusted (a) risks were presented. RESULTS: 446 patients were included, 63% (292) were older than 65 years. Survival was lower in the elderly compared to the young (p 0.007), at 3 months 87% vs. 95% and at one year 73% vs. 87%, respectively. The elderly had a HRc1.71 and HR at 1.68. The overall recurrence was 5% (95% CI 3-8) at one month, 6% (95% CI 4-9) at 3 months, 8% (95% CI). 6-11) at one year and 13% (95% CI 9-18) at two years. No association was found between age and recurrence sub hazard 0.8 (CI 0.34-1.86). Bleeding occurred in 9% (39) of the patients. CONCLUSIONS: The overall mortality in patients with confirmed VTE is higher in the elderly population. There were no differences in relation to the recurrence of VTE, or bleeding, and neither with age. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2020 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/27135 |
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I10-R10-article-271352020-11-02T20:08:23Z Mortality and recurrence of venous thromboembolic disease in adult patients: prospective cohort Mortalidad y recurrencia de la enfermedad tromboembólica venosa en pacientes adultos: cohorte prospectiva Mortalidade e recorrência da doença tromboembólica venosa em pacientes adultos: coorte prospectiva Posadas-Martinez, Maria Lourdes Pagotto, Vanina Laura Grande Ratti, Maria Florencia Alfie, Veronica Andresik, Diego Torres Gomez, Felipe Giunta, Diego Hernan Luxardo, Rosario Scolnik, Marina Vazquez, Fernando Javier tromboembolia tromboembolia venosa anciano español english portugues INTRODUCTION: Venous thromboembolic disease (VTE) is a pathology that increases with age. OBJECTIVE: to compare the survival of the elderly and the young with a first episode of acute and symptomatic VTE. MATERIALS AND METHODS: Prospective cohort of incident VTE cases included in the Institutional Registry of Venous Thromboembolic Disease (NCT01372514) of the Italian Hospital of Buenos Aires between 2012-2014, divided into young groups (17-64 years old) and elderly (65 years old). All the patients were followed annually to assess the time to recurrence (progression or new symptomatic event of VTE) as competitive events in the context of death and major bleeding. Raw (c) and adjusted (a) risks were presented. RESULTS: 446 patients were included, 63% (292) were older than 65 years. Survival was lower in the elderly compared to the young (p 0.007), at 3 months 87% vs. 95% and at one year 73% vs. 87%, respectively. The elderly had a HRc1.71 and HR at 1.68. The overall recurrence was 5% (95% CI 3-8) at one month, 6% (95% CI 4-9) at 3 months, 8% (95% CI). 6-11) at one year and 13% (95% CI 9-18) at two years. No association was found between age and recurrence sub hazard 0.8 (CI 0.34-1.86). Bleeding occurred in 9% (39) of the patients. CONCLUSIONS: The overall mortality in patients with confirmed VTE is higher in the elderly population. There were no differences in relation to the recurrence of VTE, or bleeding, and neither with age. INTRODUCCIÓN: La enfermedad tromboembólica venosa (ETV) es una patología que aumenta con la edad. Objetivo: comparar la sobrevida de los ancianos y los jóvenes con un primer episodio de ETV aguda y sintomática. MATERIALES Y MÉTODOS: Cohorte prospectiva de casos incidentes de ETV incluidos en el Registro Institucional de Enfermedad Tromboembólica venosa (NCT01372514) del Hospital Italiano de Buenos Aires entre 2012-2014, dividido en grupos jóvenes (17-64 años) y ancianos (≥ 65 años). Todos los pacientes fueron seguidos anualmente para evaluar el tiempo a la recurrencia (progresión o nuevo evento sintomático de ETV) como eventos competitivos en contexto de muerte y sangrado mayor. Se presentaron los riesgos crudos (c) y ajustados (a). RESULTADOS: se incluyeron 446 pacientes, el 63% (292) fueron mayores de 65 años. La sobrevida fue menor en los ancianos comparados con los jóvenes (p 0.007), a los 3 meses 87% vs 95% y al año 73% vs 87%, respectivamente. Los ancianos presentaron un HRc1,71 y HR a 1.68. La recurrencia global fue 5% (IC 95% 3-8) al mes, 6% (IC 95% 4-9) a los 3 meses, 8% (IC 95% 6-11) al año y 13% (IC 95% 9-18) a los dos años. No se encontró asociación entre la edad y la recurrencia sub hazard 0.8(IC 0,34-1,86). El sangrado ocurrió en un 9% (39) de los pacientes. CONCLUSIONES: La mortalidad global en pacientes con ETV confirmada es mayor en la población anciana. No hubo diferencias en relación a la recurrencia de ETV, ni el sangrado y tampoco con la edad. INTRODUÇÃO: A doença tromboembólica venosa (TEV) é uma patologia que aumenta com a idade. OBJETIVO: comparar a sobrevida de idosos e jovens com um primeiro episódio de TEV agudo e sintomático. MATERIAIS E MÉTODOS:Coorte prospectiva de casos de TEV incidentes incluídos no Registro Institucional de Doença Tromboembólica Venosa (NCT01372514) do Hospital Italiano de Buenos Aires entre 2012-2014, divididos em grupos jovens (17 a 64 anos) e idosos (65 anos) velho). Todos os pacientes foram acompanhados anualmente para avaliar o tempo de recorrência (progressão ou novo evento sintomático de TEV) como eventos competitivos no contexto de morte e sangramento grave. Os riscos brutos (c) e ajustados (a) foram apresentados. RESULTADOS:446 pacientes foram incluídos, 63% (292) tinham idade superior a 65 anos. A sobrevida foi menor nos idosos em comparação aos jovens (p 0,007), aos 3 meses 87% vs. 95% e aos um ano 73% vs. 87%, respectivamente. Os idosos apresentaram HRc1.71 e FC em 1,68. A recorrência geral foi de 5% (IC95% 3-8) em um mês, 6% (IC95% 4-9) em 3 meses, 8% (IC95%). 6-11) em um ano e 13% (IC95% 9-18) em dois anos. Não foi encontrada associação entre idade e recorrência sub-risco 0,8 (IC 0,34-1,86). Ocorreu sangramento em 9% (39) dos pacientes. CONCLUSÕES: A mortalidade geral em pacientes com TEV confirmado é maior na população idosa. Não houve diferenças em relação à recorrência de TEV ou sangramento e nem com a idade. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2020-08-21 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/27135 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 77 No. 3 (2020); 149-154 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 77 Núm. 3 (2020); 149-154 Revista da Faculdade de Ciências Médicas de Córdoba; v. 77 n. 3 (2020); 149-154 1853-0605 0014-6722 10.31053/1853.0605.v77.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/27135/31058 https://revistas.unc.edu.ar/index.php/med/article/view/27135/30591 Derechos de autor 2020 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |