Gastrointestinals stromal tumors: conceptual evolution
Gastrointestinal strornal tumors (GISTs) constitute the largest category of primary noncpithelial neoplasms of the stomach ancl small bowel. They represent about 1-2% from all neoplasrns of the digestive tract. They occur most commonly in the stomach and small bowel, but small series of comparable t...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2004
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/26873 |
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I10-R10-article-26873 |
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Universidad Nacional de Córdoba |
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Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
tumor estromal gastrointestinal leiomioblastorna tumor autonómico gastrointestinal células intersticiales de Cajal fibras eskenoides c-kit (CDII 7) CD34 . |
| spellingShingle |
tumor estromal gastrointestinal leiomioblastorna tumor autonómico gastrointestinal células intersticiales de Cajal fibras eskenoides c-kit (CDII 7) CD34 . Fonseca, Ismael B Spitale, Luis S Gramática, Luis Cejas, Hugo Piccinni, Daniel J Ghirardi, Graciela Gastrointestinals stromal tumors: conceptual evolution |
| topic_facet |
tumor estromal gastrointestinal leiomioblastorna tumor autonómico gastrointestinal células intersticiales de Cajal fibras eskenoides c-kit (CDII 7) CD34 . |
| author |
Fonseca, Ismael B Spitale, Luis S Gramática, Luis Cejas, Hugo Piccinni, Daniel J Ghirardi, Graciela |
| author_facet |
Fonseca, Ismael B Spitale, Luis S Gramática, Luis Cejas, Hugo Piccinni, Daniel J Ghirardi, Graciela |
| author_sort |
Fonseca, Ismael B |
| title |
Gastrointestinals stromal tumors: conceptual evolution |
| title_short |
Gastrointestinals stromal tumors: conceptual evolution |
| title_full |
Gastrointestinals stromal tumors: conceptual evolution |
| title_fullStr |
Gastrointestinals stromal tumors: conceptual evolution |
| title_full_unstemmed |
Gastrointestinals stromal tumors: conceptual evolution |
| title_sort |
gastrointestinals stromal tumors: conceptual evolution |
| description |
Gastrointestinal strornal tumors (GISTs) constitute the largest category of primary noncpithelial neoplasms of the stomach ancl small bowel. They represent about 1-2% from all neoplasrns of the digestive tract. They occur most commonly in the stomach and small bowel, but small series of comparable tumors havc also been reported in all the other parts of the tubular gastrointestinal tract, inclucling esophagus. colon, rectum and amis. They can also involve omcntum, mesentery, uterus, retroperitoneum. mesocolon and soft tissucs. Originally recognized ¡u 1960 by Martin ct. al. as a clist.inctive type of stromal neoplasm of the bowel, they were subsequently reported by Stout. vlio introduced the term leiomyoblastorna. Because of difficulties ¡u accurately predicting the biologic behavior of these tuniors, the terrn "smooth muscle tumor of uncertain nialignant potential" (SMT- !JMP) has heen introduced for borderline tumors. In 1983. Mazur and Clark comed the terrn gastrointestinal stronial tumor and suggested that these neoplasias might arise from (he inyenteric nervous system. Sorne studies have reported evidence of neuronal cell clifferentiation ¡o a proportion of GISTs and the terrn 'gastrointestinal autonomic nerve tumor (GANT) has been introduced. Kindblorn et al are providing cogeni arguments to suggcst that GISTs show difíerentiation toward ¡nterstitiat Cajal celis (pacemaker celis of the gastrointestinal tracl). lnmnunohistochemically the GISTs often reveal lnmunoreactivity for vimentin. CD34 and CD! 17. Tlie airn of this paper is to perforrim and analysis of the historie evolution ami conceptual of the GISTs |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2004 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/26873 |
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I10-R10-article-268732021-06-29T17:18:21Z Gastrointestinals stromal tumors: conceptual evolution Tumores estromales gastrointestinales: Evolución conceptual. Fonseca, Ismael B Spitale, Luis S Gramática, Luis Cejas, Hugo Piccinni, Daniel J Ghirardi, Graciela tumor estromal gastrointestinal leiomioblastorna tumor autonómico gastrointestinal células intersticiales de Cajal fibras eskenoides c-kit (CDII 7) CD34 . Gastrointestinal strornal tumors (GISTs) constitute the largest category of primary noncpithelial neoplasms of the stomach ancl small bowel. They represent about 1-2% from all neoplasrns of the digestive tract. They occur most commonly in the stomach and small bowel, but small series of comparable tumors havc also been reported in all the other parts of the tubular gastrointestinal tract, inclucling esophagus. colon, rectum and amis. They can also involve omcntum, mesentery, uterus, retroperitoneum. mesocolon and soft tissucs. Originally recognized ¡u 1960 by Martin ct. al. as a clist.inctive type of stromal neoplasm of the bowel, they were subsequently reported by Stout. vlio introduced the term leiomyoblastorna. Because of difficulties ¡u accurately predicting the biologic behavior of these tuniors, the terrn "smooth muscle tumor of uncertain nialignant potential" (SMT- !JMP) has heen introduced for borderline tumors. In 1983. Mazur and Clark comed the terrn gastrointestinal stronial tumor and suggested that these neoplasias might arise from (he inyenteric nervous system. Sorne studies have reported evidence of neuronal cell clifferentiation ¡o a proportion of GISTs and the terrn 'gastrointestinal autonomic nerve tumor (GANT) has been introduced. Kindblorn et al are providing cogeni arguments to suggcst that GISTs show difíerentiation toward ¡nterstitiat Cajal celis (pacemaker celis of the gastrointestinal tracl). lnmnunohistochemically the GISTs often reveal lnmunoreactivity for vimentin. CD34 and CD! 17. Tlie airn of this paper is to perforrim and analysis of the historie evolution ami conceptual of the GISTs Los tumores estrornales gastrointestinales (GastroIntestinal Stromal Tuniors - GISTs—) constituyen la categoría más amplia de neoplasias no epiteliales primarias del tracto gastrointestinal y representan aproximadamente el 1-2% de todas las neoplasias del tubo digestivo. Ocurren más frecuentemente en estómago y en intestino delgado, pero también pueden estar presentes en otros sitios del tracto gastrointestinal tubular, incluyendo esófago, colon, recto y ano. Además, han sido encontrados en sitios tales como retroperi tonco. útero, omento, mesocolon y tejidos blandos. Originalmente reconocidos en 1960 por Martin como una entidad clínicopatológica y un tipo distintivo de neoplasia estromal gástrica, los GISTs fueron posteriormente publicados por Stout. quien introdujo el término leiomioblastoma. Debido a la dificultad en predecir con seguridad el comportamiento biológico de estos tumores, el término «tumor de músculo liso de potencial maligno incierto» fue introducido para los tumores borderline. En 1983. Mazur y Clark acuñaron el término "tumor estromal gastrointestinal" y sugirieron que estas lesiones podían originarse del sistema nervioso mientérico. Algunos estudios reportaron evidencias de una diferenciación neural en algunos GISTs y fué introducido el término «tumor autonómico gastrointestinal (GANT). En 1998, Kindbiom y col., establecieron un nuevo candidato en la línea de diferenciación de los GISTs y sugirieron que estas neoplasias muestran una diferenciación inmunofenotípica hacia células intersticiales (le Cajal (células marcapasos del tracto gastrointestinal). Inmunohistoquímicamente los GISTs revelan frecuentemente inmunoreactividad para virnentina (VIM), CD34 y c-kit (CD1 17). El objetivo del presente trabajo es realizar un análisis de la evolución histórica y conceptual de los GISTs. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2004-03-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/26873 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 61 No. 1 (2004); 20 - 26 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 61 Núm. 1 (2004); 20 - 26 Revista da Faculdade de Ciências Médicas de Córdoba; v. 61 n. 1 (2004); 20 - 26 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/26873/28561 Derechos de autor 2021 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |