Rhinovirus circulation for six months in children admitted to the Hospital Infantil Municipal de Córdoba

High and low Acute Respiratory Infections (ARAs) represent the largest cause of morbidity-mortality in the world, and those of viral origin, infections are for young, elderly and immunocompromised children. At CEMIC, 186 children under the age of 5, outpatients with high and low IRAs, were studied a...

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Autores principales: Herrera Simó, C, Rodríguez, PE, Liendo, ME, Frutos, MC, Cámara, JA, Cuffini, CG, García Oro , MC, Cámara, A
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019
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Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/25769
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Sumario:High and low Acute Respiratory Infections (ARAs) represent the largest cause of morbidity-mortality in the world, and those of viral origin, infections are for young, elderly and immunocompromised children. At CEMIC, 186 children under the age of 5, outpatients with high and low IRAs, were studied at CEMIC, detecting 27% of RVh. Molecular diagnosis has shown the new impact of rhinoviruses on low IRA in children, sometimes in severity and exacerbation of asthma of chronic obstructive disease, with 43% of these being responsible for these. RVhs are important co-factors to the development of otitis media in children and sinusitis. The aim of this study was to determine the half-yearly circulation of Rinovirus by molecular biology at the Institute of Virology "Dr. J.M.Vanella" INVIV-FCM-UNC, in children interned with IRA at the Municipal Children's Hospital (HIM) in the city of Córdoba. It was a prospective survey of 326 samples that entered INVIV from September 2018, including February 2019. The samples were nasopharyngeal aspirated or nasopharyngeal hisoped from hospitalized children born to 14 years. The technique was Molecular Biology by RT-PCR in one step. Those who presented IRA-related signs and symptoms were selected, those with basic disease were not analyzed. Of the 326 samples studied, 33 were positive for RVh by Molecular Biology, giving a prevalence of 10%. They have co-infections with other agents, in a context of prevalence for Respiratory Sincicial Virus 30%, Parainfluenza I Virus  2%, Parainfluenza III Virus 4%, Metapneumovirus 4%, Influenza A 4%, in addition to bacterial co-infections. Our studies are the first on RVh by molecular biology in paediatric patients of the HIM of Córdoba. It is important to research, to reduce economic losses due to work and school absenteeism, increased medical visits, hospital overcrowding and inadequate prescription of antibiotics. The prevalence of RVH in respiratory infections has been underestimated, as its detection was slow by isolation in cell culture with low sensitivity. Our results contribute to the knowledge of this infectious agent and contribute to the prevalence reported by other authors, considering local particularities. Prevalence studies need to be continued in order to assess the impact of these infections on a larger sampling of hospitalized children in Córdoba