Importance of host sex in the development of trypanosoma cruzi infection
Multiple factors, both dependent on the host and the parasite are involved in determining resistance or susceptibility to infection with T. cruzi, but the influence of the sex of the host is a factor that has not been clearly established.In this paper we analyzed the influence of this factor upon th...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2010
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/23421 |
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I10-R10-article-234212019-05-20T10:47:10Z Importance of host sex in the development of trypanosoma cruzi infection Importancia del sexo del huésped en el desarrollo de la infección por Trypanosoma Cruzi Bazán, Paola C. Micucci, Lorena R. Fauro, Romina Baez, Alejandra Lo Presti, Maria L. Triquel, Maria F. Paglini-Oliva, Patricia A. Rivarola, Héctor W. Chagas disease Trypanosoma cruzi influence of the sex of the host cardiomyopathy Enfermedad de Chagas Trypanosoma cruzi influencia del sexo del huésped miocardiopatía Multiple factors, both dependent on the host and the parasite are involved in determining resistance or susceptibility to infection with T. cruzi, but the influence of the sex of the host is a factor that has not been clearly established.In this paper we analyzed the influence of this factor upon the infected individuals. We used Swiss albino mice infected with 50 trypomastigotes / mouse of T. cruzi, strain Tulahuen: males (n = 73) and females (n = 64). The highest parasitemia was detected on day 21 post-infection (pi) in both males and females and became negative on day 56 pi, and males exhibited significantly higher levels of parasitemia (p <0.05). The highest mortality occurred between day 21 and day 28 pi; by day 270 pi (chronic stage) one male (3%) survived every 7.6 females (23%). In skeletal muscle of male and female mice on days 90, 180 and 270 pi, lympho-monocitary infiltrates were found nests of amastigotes, whereas the myocardium of these animals showed inflammatory infiltrates only. We conclude that males showed greater susceptibility to infection and higher mortality than females in this mouse model infected with T. cruzi, Tulahuen strain, but the characteristics of the infection and cardiomyopathy development are similar in nature. Múltiples factores tanto dependientes del hospedero como del parásito se encuentran involucrados en la determinación de la resistencia o susceptibilidad a la infección con T. cruzi, pero el sexo es un factor cuya influencia no ha sido claramente establecida. En este trabajo se analizó el factor sexo en el desarrollo de la infección en los individuos infectados. Se utilizaron ratones albinos suizos infectados con 50 tripomastigotes/ratón de T. cruzi, cepa Tulahuen, divididos en: machos (n= 73) y hembras (n=64). Tanto en machos como en hembras, la mayor parasitemia se detectó a los 21 días post-infección (dpi) negativizándose a los 56 dpi, presentando los machos niveles de parasitemia significativamente mayores (p<0.05). La mayor mortalidad se produjo entre los 21 y 28 dpi, y a los 270 dpi, estadío crónico, sobrevivió un macho (3%) cada 7,6 hembras (23%). En músculo esquelético de ratones machos y hembras a los 90, 180 y 270 dpi, se encontraron infiltrados linfomonocitarios y nidos de amastigotes, mientras que el miocardio de estos mismos animales mostraron infiltrados inflamatorios solamente. Concluimos que los machos demostraron mayor susceptibilidad a la infección y consecuentemente más mortalidad que las hembras, en este modelo murino infectados con T. cruzi cepa Tulahuen, pero que las características de la infección y la miocardiopatía que desarrollan son de características similares. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2010-07-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/23421 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 67 No. 2 (2010); 69-72 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 67 Núm. 2 (2010); 69-72 Revista da Faculdade de Ciências Médicas de Córdoba; v. 67 n. 2 (2010); 69-72 1853-0605 0014-6722 10.31053/1853.0605.v67.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/23421/23143 Derechos de autor 2019 Universidad Nacional de Córdoba |
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Universidad Nacional de Córdoba |
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R-10 |
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Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
Chagas disease Trypanosoma cruzi influence of the sex of the host cardiomyopathy Enfermedad de Chagas Trypanosoma cruzi influencia del sexo del huésped miocardiopatía |
| spellingShingle |
Chagas disease Trypanosoma cruzi influence of the sex of the host cardiomyopathy Enfermedad de Chagas Trypanosoma cruzi influencia del sexo del huésped miocardiopatía Bazán, Paola C. Micucci, Lorena R. Fauro, Romina Baez, Alejandra Lo Presti, Maria L. Triquel, Maria F. Paglini-Oliva, Patricia A. Rivarola, Héctor W. Importance of host sex in the development of trypanosoma cruzi infection |
| topic_facet |
Chagas disease Trypanosoma cruzi influence of the sex of the host cardiomyopathy Enfermedad de Chagas Trypanosoma cruzi influencia del sexo del huésped miocardiopatía |
| author |
Bazán, Paola C. Micucci, Lorena R. Fauro, Romina Baez, Alejandra Lo Presti, Maria L. Triquel, Maria F. Paglini-Oliva, Patricia A. Rivarola, Héctor W. |
| author_facet |
Bazán, Paola C. Micucci, Lorena R. Fauro, Romina Baez, Alejandra Lo Presti, Maria L. Triquel, Maria F. Paglini-Oliva, Patricia A. Rivarola, Héctor W. |
| author_sort |
Bazán, Paola C. |
| title |
Importance of host sex in the development of trypanosoma cruzi infection |
| title_short |
Importance of host sex in the development of trypanosoma cruzi infection |
| title_full |
Importance of host sex in the development of trypanosoma cruzi infection |
| title_fullStr |
Importance of host sex in the development of trypanosoma cruzi infection |
| title_full_unstemmed |
Importance of host sex in the development of trypanosoma cruzi infection |
| title_sort |
importance of host sex in the development of trypanosoma cruzi infection |
| description |
Multiple factors, both dependent on the host and the parasite are involved in determining resistance or susceptibility to infection with T. cruzi, but the influence of the sex of the host is a factor that has not been clearly established.In this paper we analyzed the influence of this factor upon the infected individuals. We used Swiss albino mice infected with 50 trypomastigotes / mouse of T. cruzi, strain Tulahuen: males (n = 73) and females (n = 64). The highest parasitemia was detected on day 21 post-infection (pi) in both males and females and became negative on day 56 pi, and males exhibited significantly higher levels of parasitemia (p <0.05). The highest mortality occurred between day 21 and day 28 pi; by day 270 pi (chronic stage) one male (3%) survived every 7.6 females (23%). In skeletal muscle of male and female mice on days 90, 180 and 270 pi, lympho-monocitary infiltrates were found nests of amastigotes, whereas the myocardium of these animals showed inflammatory infiltrates only. We conclude that males showed greater susceptibility to infection and higher mortality than females in this mouse model infected with T. cruzi, Tulahuen strain, but the characteristics of the infection and cardiomyopathy development are similar in nature. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2010 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/23421 |
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