Chemical ablation of the gallbladder with sodium hypochlorite in an animal model
Introduction: The cholecystectomy is the current treatment of the biliary lithiasis. Nevertheless there have been attempts in order to eliminate the gallbladder epithelium and to generate the sclerosis of the organ using chemical substances, heat and laser.Objetive: Sodium hypochlorite and fibrin gl...
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| Formato: | Artículo revista |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2011
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/21528 |
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I10-R10-article-21528 |
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Universidad Nacional de Córdoba |
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Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
gallbladder chemical ablation sclerotherapy cholecystectomy vesícula biliar ablación química escleroterapia colecistectomía |
| spellingShingle |
gallbladder chemical ablation sclerotherapy cholecystectomy vesícula biliar ablación química escleroterapia colecistectomía Jover Clos, Rafael J. Álamo, Juan P. Matsuzaki, Mónica Dionisio de Cabalier, María Elisa Bustos, Héctor F. Gramatica, Luis Chemical ablation of the gallbladder with sodium hypochlorite in an animal model |
| topic_facet |
gallbladder chemical ablation sclerotherapy cholecystectomy vesícula biliar ablación química escleroterapia colecistectomía |
| author |
Jover Clos, Rafael J. Álamo, Juan P. Matsuzaki, Mónica Dionisio de Cabalier, María Elisa Bustos, Héctor F. Gramatica, Luis |
| author_facet |
Jover Clos, Rafael J. Álamo, Juan P. Matsuzaki, Mónica Dionisio de Cabalier, María Elisa Bustos, Héctor F. Gramatica, Luis |
| author_sort |
Jover Clos, Rafael J. |
| title |
Chemical ablation of the gallbladder with sodium hypochlorite in an animal model |
| title_short |
Chemical ablation of the gallbladder with sodium hypochlorite in an animal model |
| title_full |
Chemical ablation of the gallbladder with sodium hypochlorite in an animal model |
| title_fullStr |
Chemical ablation of the gallbladder with sodium hypochlorite in an animal model |
| title_full_unstemmed |
Chemical ablation of the gallbladder with sodium hypochlorite in an animal model |
| title_sort |
chemical ablation of the gallbladder with sodium hypochlorite in an animal model |
| description |
Introduction: The cholecystectomy is the current treatment of the biliary lithiasis. Nevertheless there have been attempts in order to eliminate the gallbladder epithelium and to generate the sclerosis of the organ using chemical substances, heat and laser.Objetive: Sodium hypochlorite and fibrin glue is proposed to achieve the ablation of the gallbladder mucosa and sclerosis.Materials and methods: Thirty rabbits were divided into three groups of 10. Accessing surgically to the gallbladder, sodium hypochlorite was injected, afterward the same was done with fibrin glue to occlude the cystic duct and collapse the organ lumen, avoiding the bile reflux. In the control groups ethanol plus fibrin adhesive and physiological solution was used. In day 65 the animals were sacrificed and the result of the procedure was observed macroscopic and histologically.Results: Eight of the gallbladders treated with sodium hypochlorite disappeared leaving a small subhepatic scar. There were no intra nor postoperative complications. In the group of the ethanol the result was successful only in one case, and with saline solution there was no ablation. A significant difference exists for the group treated with sodium hypochlorite plus fibrin glue compared to the ethanol plus fibrin adhesive group (p <0,0055) and the saline solution group (p <0,0007).Conclusion: In this experimental model there was possible the ablation of the gallbladder using sodium hypochlorite as sclerosing agent and fibrin glue to collapse the lumen and to occlude the cystic duct. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2011 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/21528 |
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I10-R10-article-215282019-05-10T12:40:48Z Chemical ablation of the gallbladder with sodium hypochlorite in an animal model Ablación química de la vesícula biliar con hipoclorito de sodio en un modelo animal Jover Clos, Rafael J. Álamo, Juan P. Matsuzaki, Mónica Dionisio de Cabalier, María Elisa Bustos, Héctor F. Gramatica, Luis gallbladder chemical ablation sclerotherapy cholecystectomy vesícula biliar ablación química escleroterapia colecistectomía Introduction: The cholecystectomy is the current treatment of the biliary lithiasis. Nevertheless there have been attempts in order to eliminate the gallbladder epithelium and to generate the sclerosis of the organ using chemical substances, heat and laser.Objetive: Sodium hypochlorite and fibrin glue is proposed to achieve the ablation of the gallbladder mucosa and sclerosis.Materials and methods: Thirty rabbits were divided into three groups of 10. Accessing surgically to the gallbladder, sodium hypochlorite was injected, afterward the same was done with fibrin glue to occlude the cystic duct and collapse the organ lumen, avoiding the bile reflux. In the control groups ethanol plus fibrin adhesive and physiological solution was used. In day 65 the animals were sacrificed and the result of the procedure was observed macroscopic and histologically.Results: Eight of the gallbladders treated with sodium hypochlorite disappeared leaving a small subhepatic scar. There were no intra nor postoperative complications. In the group of the ethanol the result was successful only in one case, and with saline solution there was no ablation. A significant difference exists for the group treated with sodium hypochlorite plus fibrin glue compared to the ethanol plus fibrin adhesive group (p <0,0055) and the saline solution group (p <0,0007).Conclusion: In this experimental model there was possible the ablation of the gallbladder using sodium hypochlorite as sclerosing agent and fibrin glue to collapse the lumen and to occlude the cystic duct. Antecedentes: El tratamiento actual de la litiasis vesicular es la colecistectomía. Pero han habido intentos de eliminar la vesícula biliar sin recurrir a la cirugía. Para ello se han usado sustancias químicas, calor y láser para destruir la mucosa y generar la esclerosis del órgano.Objetivos: Se propone el uso de hipoclorito de sodio para lograr la mucoclasia vesicular y posterior esclerosis, y la cola de fibrina para obliteración de la luz vesicular.Materiales y métodos: Se dividieron 30 conejos neozelandeses en tres grupos de 10. Se accedió quirúrgicamente a la vesícula biliar y se inyectó hipoclorito de sodio, y posteriormente cola de fibrina para tapar la comunicación con el cístico y colapsar las paredes vesiculares. En los grupos controles se usó etanol más cola de fibrina y solución fisiológica. A los 65 días se sacrificaron los animales y se observó el resultado del procedimiento macroscópica e histológicamente.Resultados: Ocho de las vesículas tratadas con hipoclorito se esclerosaron completamente. No hubo complicaciones intra ni post operatorias. En el grupo del etanol el resultado fue exitoso solo en un caso, con solución fisiológica no hubo ablación. La comparación de los resultados demostró una diferencia significativa favorable al grupo tratado con hipoclorito en comparación con el de etanol más cola de fibrina (p<0,0055) y el de solución fisiológica (p<0,0007).Conclusiones: En este modelo experimental, fue posible la ablación completa de la vesícula biliar usando hipoclorito de sodio como esclerosante y cola de fibrina para obturar el cístico y la luz vesicular. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2011-09-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/21528 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 68 No. 3 (2011); 101-106 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 68 Núm. 3 (2011); 101-106 Revista da Faculdade de Ciências Médicas de Córdoba; v. 68 n. 3 (2011); 101-106 1853-0605 0014-6722 10.31053/1853.0605.v68.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/21528/21251 Derechos de autor 2018 Universidad Nacional de Córdoba |