Polycystic ovary syndrome: physiopathology review

Mostrar todas las versiones(2)

Polycystic ovary syndrome (PCOS), the most common gynecological endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, chronic anovulation and /or polycystic ovaries. Although the cause of PCOS is still unknown, there are several hypotheses attempting to explain the prima...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Fux Otta, Carolina, Fiol de Cuneo, Marta, Szafryk de Mereshian, Paula
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2013
Materias:
polycystic ovary syndrome
insulin resistance
physiopathology
síndrome de ovario poliquístico
insulino resistencia
fisiopatogenia
ovario poliquístico
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/20282
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-20282
record_format ojs
spelling I10-R10-article-202822022-03-10T18:47:45Z Polycystic ovary syndrome: physiopathology review Sindrome de Ovario Poliquístico: Revisión de su fisiopatogenia Fux Otta, Carolina Fiol de Cuneo, Marta Szafryk de Mereshian, Paula polycystic ovary syndrome insulin resistance physiopathology síndrome de ovario poliquístico insulino resistencia fisiopatogenia ovario poliquístico Polycystic ovary syndrome (PCOS), the most common gynecological endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, chronic anovulation and /or polycystic ovaries. Although the cause of PCOS is still unknown, there are several hypotheses attempting to explain the primary defect; the most commonly accepted is insulin resistance. Due to its high prevalence, the patients have increased risk of developing metabolic and cardiovascular alterations. The compensatory hyperinsulinemia contributes to hyperandrogenism in different ways: by stimulating ovarian androgen synthesis and inhibiting hepaticproduction of sex hormone binding globulin. From the study of the intrauterine environment in recent years it has been suggested that PCOS may have an origin in utero associated with prenatal exposure to androgens.The aim of this paper is to review the main mechanisms proposed to cause the syndrome El síndrome de ovario poliquístico (SOP), la endocrinopatía ginecológica más frecuente en mujeres en edad fértil, se caracteriza por hiperandrogenismo, anovulación crónica y/u ovarios poliquísticos. A pesar de que su etiología permanece desconocida y que se han propuesto diferentes hipótesis, en la actualidad se jerarquiza a la insulino resistencia como la principal causante del síndrome y su implicancia en las alteraciones metabólicas. La hiperinsulinemia compensatoria contribuye al hiperandrogenismo por diferentes vías: estimulando la síntesis ovárica de andrógenos e inhibiendo la producción hepática de la globulina transportadora de hormonas sexuales. A partir del estudio del ambiente intrauterino, en los últimos años se ha propuesto que el SOP podría tener un origen in útero relacionado con la exposición prenatal a andrógenos. El objetivo del presente trabajo es revisar las principales mecanismos propuestos como causantes del síndrome. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2013-03-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/20282 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 70 No. 1 (2013); 27-30 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 70 Núm. 1 (2013); 27-30 Revista da Faculdade de Ciências Médicas de Córdoba; v. 70 n. 1 (2013); 27-30 1853-0605 0014-6722 10.31053/1853.0605.v70.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/20282/37258 Derechos de autor 2018 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic polycystic ovary syndrome
insulin resistance
physiopathology
síndrome de ovario poliquístico
insulino resistencia
fisiopatogenia
ovario poliquístico
spellingShingle polycystic ovary syndrome
insulin resistance
physiopathology
síndrome de ovario poliquístico
insulino resistencia
fisiopatogenia
ovario poliquístico
Fux Otta, Carolina
Fiol de Cuneo, Marta
Szafryk de Mereshian, Paula
Polycystic ovary syndrome: physiopathology review
topic_facet polycystic ovary syndrome
insulin resistance
physiopathology
síndrome de ovario poliquístico
insulino resistencia
fisiopatogenia
ovario poliquístico
author Fux Otta, Carolina
Fiol de Cuneo, Marta
Szafryk de Mereshian, Paula
author_facet Fux Otta, Carolina
Fiol de Cuneo, Marta
Szafryk de Mereshian, Paula
author_sort Fux Otta, Carolina
title Polycystic ovary syndrome: physiopathology review
title_short Polycystic ovary syndrome: physiopathology review
title_full Polycystic ovary syndrome: physiopathology review
title_fullStr Polycystic ovary syndrome: physiopathology review
title_full_unstemmed Polycystic ovary syndrome: physiopathology review
title_sort polycystic ovary syndrome: physiopathology review
description Polycystic ovary syndrome (PCOS), the most common gynecological endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, chronic anovulation and /or polycystic ovaries. Although the cause of PCOS is still unknown, there are several hypotheses attempting to explain the primary defect; the most commonly accepted is insulin resistance. Due to its high prevalence, the patients have increased risk of developing metabolic and cardiovascular alterations. The compensatory hyperinsulinemia contributes to hyperandrogenism in different ways: by stimulating ovarian androgen synthesis and inhibiting hepaticproduction of sex hormone binding globulin. From the study of the intrauterine environment in recent years it has been suggested that PCOS may have an origin in utero associated with prenatal exposure to androgens.The aim of this paper is to review the main mechanisms proposed to cause the syndrome
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2013
url https://revistas.unc.edu.ar/index.php/med/article/view/20282
work_keys_str_mv AT fuxottacarolina polycysticovarysyndromephysiopathologyreview
AT fioldecuneomarta polycysticovarysyndromephysiopathologyreview
AT szafrykdemereshianpaula polycysticovarysyndromephysiopathologyreview
AT fuxottacarolina sindromedeovariopoliquisticorevisiondesufisiopatogenia
AT fioldecuneomarta sindromedeovariopoliquisticorevisiondesufisiopatogenia
AT szafrykdemereshianpaula sindromedeovariopoliquisticorevisiondesufisiopatogenia
first_indexed 2022-08-20T01:25:31Z
last_indexed 2022-08-20T01:25:31Z
_version_ 1770718928053469184

Ejemplares similares