Comparison of the efficacy and tolerability of chondroitin plus glucosamine and D-002 (beeswax alcohols) in subjects with osteoarthritis symptoms

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Background/AIMS: Osteoarthritis (OA), the commonest joint disorder, is a leading cause of disability. Symptomatic slow-acting drugs for OA (SYSADOA), particularly glucosamine plus chondroitin sulphate (GS/CS), are effective for symptom relief, protect joint cartilage and delay OA progression, with a...

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Autores principales: Mendoza, Sarahi, Puente, Roberto, Illnait, José, Mas, Rosa, López, Ernesto, Carbajal, Daisy, Fernández, Lilia, Fernández, Julio, Mesa, Meilis, Reyes, Pablo, Ruiz, Dalmer
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
D-002
beeswax alcohols
chondroitin sulphate
glucosamine
osteoarthritis
WOMAC score
VAS score
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/14479
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Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-14479
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spelling I10-R10-article-144792019-05-20T10:36:32Z Comparison of the efficacy and tolerability of chondroitin plus glucosamine and D-002 (beeswax alcohols) in subjects with osteoarthritis symptoms Mendoza, Sarahi Puente, Roberto Illnait, José Mas, Rosa López, Ernesto Carbajal, Daisy Fernández, Lilia Fernández, Julio Mesa, Meilis Reyes, Pablo Ruiz, Dalmer D-002 beeswax alcohols chondroitin sulphate glucosamine osteoarthritis WOMAC score VAS score Background/AIMS: Osteoarthritis (OA), the commonest joint disorder, is a leading cause of disability. Symptomatic slow-acting drugs for OA (SYSADOA), particularly glucosamine plus chondroitin sulphate (GS/CS), are effective for symptom relief, protect joint cartilage and delay OA progression, with a good safety profile. D-002, a mixture of beeswax alcohols that inhibits both cyclooxygenase and 5-lipoxygenase activities, has been effective in experimental and clinical OA studies, showing also a chondroprotective effect.OBJECTIVES: To compare the effects of D-002 and GS/SC administered for 12 weeks on OA symptoms.METHODS: Participants were randomized to GS/CS (375/300 mg) or 50?mg D-002 once daily for 12 weeks. Symptoms were assessed by the Western Ontario and McMaster Individual Osteoarthritis Index (WOMAC) and the visual analogy scale (VAS) scores. The primary outcome was the reduction of the total WOMAC score. Secondary outcomes included WOMAC pain, stiffness and function scores, VAS score and rescue medication consumption.RESULTS: Of 60 randomized patients, 59 completed the study. D-002 and GS/SC reduced significantly total WOMAC score (72.1% and 78.5%, respectively), and pain, joint stiffness and physical function scores versus baseline. VAS scores decreased significantly with D-002 (76.6%) and GS/SC (76.8%). The reductions, significant from the second week, were enhanced over the trial. Rescue medications were consumed by 3/30 D-002 and 4/30 GS/SC patients. No differences between groups were found. Treatments were well tolerated.CONCLUSIONS: D-002 (50 mg/day) administered for 12 weeks was safe and comparable to GS/SC for alleviating OA symptoms (pain, stiffness, and functional limitation) (RPCEC00000180). Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017-06-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/14479 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 74 No. 2 (2017); 107-118 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 74 Núm. 2 (2017); 107-118 Revista da Faculdade de Ciências Médicas de Córdoba; v. 74 n. 2 (2017); 107-118 1853-0605 0014-6722 10.31053/1853.0605.v74.n2 eng https://revistas.unc.edu.ar/index.php/med/article/view/14479/16725 Derechos de autor 2017 Universidad Nacional de Córdoba
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Inglés
format Artículo revista
topic D-002
beeswax alcohols
chondroitin sulphate
glucosamine
osteoarthritis
WOMAC score
VAS score
spellingShingle D-002
beeswax alcohols
chondroitin sulphate
glucosamine
osteoarthritis
WOMAC score
VAS score
Mendoza, Sarahi
Puente, Roberto
Illnait, José
Mas, Rosa
López, Ernesto
Carbajal, Daisy
Fernández, Lilia
Fernández, Julio
Mesa, Meilis
Reyes, Pablo
Ruiz, Dalmer
Comparison of the efficacy and tolerability of chondroitin plus glucosamine and D-002 (beeswax alcohols) in subjects with osteoarthritis symptoms
topic_facet D-002
beeswax alcohols
chondroitin sulphate
glucosamine
osteoarthritis
WOMAC score
VAS score
author Mendoza, Sarahi
Puente, Roberto
Illnait, José
Mas, Rosa
López, Ernesto
Carbajal, Daisy
Fernández, Lilia
Fernández, Julio
Mesa, Meilis
Reyes, Pablo
Ruiz, Dalmer
author_facet Mendoza, Sarahi
Puente, Roberto
Illnait, José
Mas, Rosa
López, Ernesto
Carbajal, Daisy
Fernández, Lilia
Fernández, Julio
Mesa, Meilis
Reyes, Pablo
Ruiz, Dalmer
author_sort Mendoza, Sarahi
title Comparison of the efficacy and tolerability of chondroitin plus glucosamine and D-002 (beeswax alcohols) in subjects with osteoarthritis symptoms
title_short Comparison of the efficacy and tolerability of chondroitin plus glucosamine and D-002 (beeswax alcohols) in subjects with osteoarthritis symptoms
title_full Comparison of the efficacy and tolerability of chondroitin plus glucosamine and D-002 (beeswax alcohols) in subjects with osteoarthritis symptoms
title_fullStr Comparison of the efficacy and tolerability of chondroitin plus glucosamine and D-002 (beeswax alcohols) in subjects with osteoarthritis symptoms
title_full_unstemmed Comparison of the efficacy and tolerability of chondroitin plus glucosamine and D-002 (beeswax alcohols) in subjects with osteoarthritis symptoms
title_sort comparison of the efficacy and tolerability of chondroitin plus glucosamine and d-002 (beeswax alcohols) in subjects with osteoarthritis symptoms
description Background/AIMS: Osteoarthritis (OA), the commonest joint disorder, is a leading cause of disability. Symptomatic slow-acting drugs for OA (SYSADOA), particularly glucosamine plus chondroitin sulphate (GS/CS), are effective for symptom relief, protect joint cartilage and delay OA progression, with a good safety profile. D-002, a mixture of beeswax alcohols that inhibits both cyclooxygenase and 5-lipoxygenase activities, has been effective in experimental and clinical OA studies, showing also a chondroprotective effect.OBJECTIVES: To compare the effects of D-002 and GS/SC administered for 12 weeks on OA symptoms.METHODS: Participants were randomized to GS/CS (375/300 mg) or 50?mg D-002 once daily for 12 weeks. Symptoms were assessed by the Western Ontario and McMaster Individual Osteoarthritis Index (WOMAC) and the visual analogy scale (VAS) scores. The primary outcome was the reduction of the total WOMAC score. Secondary outcomes included WOMAC pain, stiffness and function scores, VAS score and rescue medication consumption.RESULTS: Of 60 randomized patients, 59 completed the study. D-002 and GS/SC reduced significantly total WOMAC score (72.1% and 78.5%, respectively), and pain, joint stiffness and physical function scores versus baseline. VAS scores decreased significantly with D-002 (76.6%) and GS/SC (76.8%). The reductions, significant from the second week, were enhanced over the trial. Rescue medications were consumed by 3/30 D-002 and 4/30 GS/SC patients. No differences between groups were found. Treatments were well tolerated.CONCLUSIONS: D-002 (50 mg/day) administered for 12 weeks was safe and comparable to GS/SC for alleviating OA symptoms (pain, stiffness, and functional limitation) (RPCEC00000180).
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/14479
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first_indexed 2022-08-20T01:24:39Z
last_indexed 2022-08-20T01:24:39Z
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