Genotoxic damage induced by isopropanol in germinal and somatic cells of Drosophila melanogaster
Isopropanol (isopropyl alcohol, 2-propanol, IPA) is a volatile solvent widely used in domestic or industrial environments and reported as innocuous in various test systems. The aim of this work was to search for in vivo genotoxic effects of IPA in Drosophila melanogaster, studying its ability to ind...
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2011
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| LEADER | 17036caa a22015137a 4500 | ||
|---|---|---|---|
| 001 | PAPER-9995 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203959.0 | ||
| 008 | 190411s2011 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-81055156598 | |
| 024 | 7 | |2 cas |a 2 propanol, 67-63-0; 2-Propanol, 67-63-0; Mutagens | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MRGMF | ||
| 100 | 1 | |a Palermo, A.M. | |
| 245 | 1 | 0 | |a Genotoxic damage induced by isopropanol in germinal and somatic cells of Drosophila melanogaster |
| 260 | |c 2011 | ||
| 270 | 1 | 0 | |m Palermo, A.M.; CITEDEF, J.B. de La Salle 4397, B1603ALO, Villa Martelli, Buenos Aires, Argentina; email: apalermo@citedef.gov.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a (1989), USEPA, Toxic Substances Act Section 4, Final Test Rule on Isopropanol, 54 FR 43252, October 23, 1989; (1995), U.S. EPA. R.E.D. FACTS, Aliphatic Alcohols, EPA-738-F-95-012, April; Johnson, F.M., How many high production chemicals are rodent carcinogens? Why should we care? What do we need to do about it? (2003) Mutat. Res., 543, pp. 201-215 | ||
| 504 | |a Kapp, R.W., Bevan, C., Gardiner, T.H., Banton, M.I., Tyler, T.R., Wright, G.A., Isopropanol: summary of TSCA test rule studies and relevance to hazard identification (1996) Regul. Toxicol. Pharmacol., 23, pp. 183-192 | ||
| 504 | |a Maizlish, N.A., Langolf, G.D., Whitehead, L.W., Fine, L.J., Albers, J.W., Goldberg, J., Smith, P., Behavioral evaluation of workers exposed to mixtures of organic solvents (1985) Br. J. Ind. Med., 42, pp. 579-590 | ||
| 504 | |a Sethre, T., Llauri, T., Berode, M., Krieger, H., Neurobehavioral effects of experimental isopropanol exposure (2000) Int. Arch. Occup. Environ. Health, 73, pp. 105-112 | ||
| 504 | |a Smeets, M.A.M., Mauté, C., Dalton, P.H., Acute sensory irritation from exposure to isopropanol (2-propanol) at TLV in workers and controls: objective versus subjective effects (2002) Ann. Occup. Hyg., 46, pp. 359-373 | ||
| 504 | |a Nelson, B.K., Brightwell, W.S., MacKenzie-Taylor, D.R., Khan, A., Burg, J.E., Weigel, W.W., Goad, P.T., Teratogenicity of n-propanol and isopropanol administered at high inhalation concentrations to rats (1988) Food Chem. Toxicol., 26, pp. 247-254 | ||
| 504 | |a (1990) Environmental Health Criteria 103: 2-Propanol, , WHO (World Health Organization). Office of Publications, WHO, Geneva, Switzerland | ||
| 504 | |a Tyl, R.W., Masten, L.W., Marr, M.C., Mayers, C.B., Slauter, R.W., Gardiner, T.H., Strother, D.E., Tyler, T.R., Developmental toxicity of isopropanol by gavage in rats and rabbits (1994) Fundam. Appl. Toxicol., 22, pp. 139-151 | ||
| 504 | |a Burleigh-Flayer, H., Garman, R., Neptun, D., Bevan, C., Gardiner, T., Kapp, R., Tyler, T., Wright, G., Isopropanol vapor inhalation oncogenicity study in Fischer 344 rats and CD-1 mice (1997) Fundam. Appl. Toxicol., 36, pp. 95-111 | ||
| 504 | |a Weil, C.S., Smyth, H.F., Nale, T.W., Quest for a suspected industrial carcinogen (1952) A.M.A. Arch. Ind. Hyg. Occup. Med., 5, pp. 535-547 | ||
| 504 | |a Kapp, R.W., Marino, D.J., Gardiner, T.H., Masten, L.W., McKee, R.H., Tyler, T.R., Ivett, J.L., Young, R.R., In vitro and in vivo assays of isopropanol for mutagenicity (1993) Environ. Mol. Mutagen., 22, pp. 93-100 | ||
| 504 | |a Shimizu, H., Suzuki, Y., Takemura, N., Goto, S., Matsushita, H., Results of microbial mutation tests for forty three industrial chemicals (1985) Sangyo Igaku, 27, pp. 400-419 | ||
| 504 | |a Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., Salmonella mutagenicity tests, V. Results from the testing of 311 chemicals (1992) Environ. Mol. Mutagen., 19 (SUPPL. 21), pp. 2-141 | ||
| 504 | |a Duesberg, P., Rasnick, D., Aneuploidy, the somatic mutation that makes cancer a species of its own (2000) Cell Motil. Cytoskeleton, 47, pp. 81-107 | ||
| 504 | |a Williams, B.R., Prabhu, V.R., Hunter, K.E., Glazier, C.M., Whittaker, C.A., Housman, D.E., Amon, A., Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells (2008) Science, 322, pp. 703-709 | ||
| 504 | |a Graf, U., Würgler, F.E., Katz, A.J., Frei, H., Juon, H., Hall, C.B., Kale, P.G., Somatic mutation and recombination test in Drosophila melanogaster (1984) Environ. Mutagen., 6, pp. 153-188 | ||
| 504 | |a Nöthinger, R., Sucrose density separation: a method for collecting large numbers of Drosophila larvae (1970) Drosophila Inform. Serv., 45, p. 117 | ||
| 504 | |a Muñoz, E.R., A test for detecting maternal nondisjuction in Drosophila melanogaster (1992) Drosophila Inf. Serv., 71, pp. 228-229 | ||
| 504 | |a Muñoz, E.R., Mazar Barnett, B., Chromosome malsegregation induced by the rodent carcinogens acetamide, pyridine and diethanolamine in Drosophila melanogaster females (2003) Mutat. Res., 539, pp. 137-144 | ||
| 504 | |a Lindsley, D.L., Zimm, G.G., (1992) The Genome of Drosophila melanogaster, pp. 1-1133. , Academic Press, New York | ||
| 504 | |a Grell, R.F., Muñoz, E.R., Kirschbaum, W.F., Radiation-induced nondisjunction and loss of chromosomes in Drosophila melanogaster females, part I, the effect of chromosome size (1966) Mutat. Res., 3, pp. 494-502 | ||
| 504 | |a Traut, H., Nondisjunction induced by X-rays in oocytes of Drosophila melanogaster (1970) Mutat. Res., 10, pp. 125-132 | ||
| 504 | |a King, R.C., (1970) Ovarian Development in Drosophila melanogaster, , Academic Press, New York | ||
| 504 | |a Margolin, B.H., Collings, B.J., Mason, J.M., Statistical analysis and sample-size determinations for mutagenicity experiments with binomial responses (1983) Environ. Mutagen., 5, pp. 705-716 | ||
| 504 | |a Vogel, E.W., Tests for recombinagens in somatic cells of Drosophila (1992) Mutat. Res., 284, pp. 159-175 | ||
| 504 | |a Vogel, E.W., Nivard, M.J.M., Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination (1993) Mutagenesis, 8, pp. 57-81 | ||
| 504 | |a Vogel, E.W., Nivard, M.J.M., A novel method for the parallel monitoring of mitotic recombination and clastogenicity in somatic cells in vivo (1999) Mutat. Res., 431, pp. 141-153 | ||
| 504 | |a Vogel, E.W., Nivard, M.J.M., Parallel monitoring of mitotic recombination, clastogenicity and teratogenic effects in eye tissue of Drosophila (2000) Mutat. Res., 455, pp. 141-153 | ||
| 504 | |a Frei, H., Würgler, F.E., Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive negative or inconclusive result (1988) Mutat. Res., 203, pp. 297-308 | ||
| 504 | |a Frei, H., Würgler, F.E., Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila (1995) Mutat. Res., 334, pp. 247-258 | ||
| 504 | |a Mazar Barnett, B.M., Muñoz, E.R., Genetic damage induced by methylglyoxal and methylglyoxal plus X-rays in Drosophila melanogaster germinal cells (1998) Mutat. Res., 421, pp. 37-43 | ||
| 504 | |a Kastenbaum, M.A., Bowman, K.O., Tables for determining the statistical significance of mutation frequencies (1970) Mutat. Res., 9, pp. 527-549 | ||
| 504 | |a Lington, A.W., Bevan, C., Alcohols (1994) Patty's Industrial Hygiene and Toxicology, 2, pp. 2585-2760. , Wiley, New York, Part D | ||
| 504 | |a Vale, A., Isopropanol (2007) Medicine, 35, p. 626 | ||
| 504 | |a Faber, W.D., Pavkov, K.L., Gingell, R., Review of reproductive and developmental toxicity studies with isopropanol (2008) Birth Defects Res. B, Dev. Reprod. Toxicol, 83, pp. 459-476 | ||
| 504 | |a Schneider, D., Using Drosophila as a model insect (2000) Nat. Rev. Genet., 1, pp. 218-226 | ||
| 504 | |a Sharma, A., Shukla, A.K., Mishra, M., Chowdhuri, D.K., Validation and application of Drosophila melanogaster as an in vivo model for the detection of double strand breaks by neutral Comet assay (2011) Mutat. Res., 721, pp. 142-146 | ||
| 504 | |a Rubin, G.M., Yandell, M.D., Wortman, J.R., Miklos, G.L.G., Nelson, C.R., Hariharan, I.K., Fortini, M.E., Fleischmann, W., Comparative genomics of the eukaryotes (2000) Science, 287, pp. 2204-2215 | ||
| 504 | |a Vogel, E.W., Graf, U., Frei, H.J., Nivard, M.M., The results of assays in Drosophila as indicators of exposure to carcinogens (1999) IARC Sci. Publ., 146, pp. 427-470 | ||
| 504 | |a von der Hude, W., Scheutwinkel, M., Gramlich, U., Fissler, B., Basler, A., Genotoxicity of three-carbon compounds evaluated in the SCE test in vitro (1987) Environ. Mutagen., 9, pp. 401-410 | ||
| 504 | |a Brockman, H.E., de Serres, F.J., Ong, T.M., DeMarini, D.M., Katz, A.J., Griffiths, A.J., Stafford, R.S., Mutation tests in Neurospora crassa, a report of the US Environmental Protection Agency Gene-Tox Program (1984) Mutat. Res., 133, pp. 87-134 | ||
| 504 | |a Heidelberger, C., Freeman, A.E., Pienta, R.J., Sivak, A., Bertram, J.S., Casto, B.C., Dunkel, V.C., Schechtman, L.M., Cell transformation by chemical agents - a review and analysis of the literature, a report of the U.S. Environmental Protection Agency Gene-Tox Program (1983) Mutat. Res., 114, pp. 283-385 | ||
| 504 | |a Re-evaluation of some organic chemicals (1999) Hydrazine Hydrogen Peroxide, 71 (PART 3A), pp. 1027-1036. , IARC Monographs on the Evaluation of Carcinogenic Risks to Humans | ||
| 504 | |a Overall evaluations of carcinogenicity (1987) IARC Monogr., (SUPPL. 7), pp. p229. , IARC Monographs on the Evaluation of Carcinogenic Risks to Humans | ||
| 504 | |a David, J.R., Van Herrewege, J., Scheemaeker-Louis, M., Pla, E., Drosophila alcohol dehydrogenase: detoxification of isopropanol and acetone, substances not used in energy metabolism (1981) Heredity, 47, pp. 263-268 | ||
| 504 | |a Guillén, E., Sanchez-Cañete, F.J.S., Garrido, J.J., Dorado, G., Barbancho, M., Intergenotypic effect of isopropanol ingestion in the further detoxification of ethanol and isopropanol in Drosophila melanogaster (1987) Heredity, 59, pp. 405-411 | ||
| 504 | |a Graf, U., Singer, D., Genotoxicity testing of promutagens in the wing somatic mutation and recombination test in Drosophila melanogaster (1992) Rev. Int. Contam. Ambient, 8, pp. 15-27 | ||
| 504 | |a Vazquez-Gomez, G., Sanchez-Santos, A., Vazquez-Medrano, J., Quintanar-Zuniga, R., Monsalvo-Reyes, A.C., Piedra-Ibarra, E., Duenas-Garcia, I.E., Heres-Pulido, M.E., Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross (2010) Food Chem. Toxicol., 48, pp. 3333-3339 | ||
| 504 | |a Zimmermann, F.K., Mayer, V.W., Scheel, I., Resnick, M.A., Acetone, methyl ethyl ketone, ethyl acetate, acetonitrile and other polar aprotic solvents are strong inducers of aneuploidy in Saccharomyces cerevisiae (1985) Mutat. Res., 149, pp. 339-351 | ||
| 504 | |a Zimmermann, F.K., Gröschel-Stewart, U., Scheel, I., Resnick, M.A., Genetic change may be caused by interference with protein-protein interactions (1985) Mutat. Res., 150, pp. 203-210 | ||
| 504 | |a Decordier, I., Cundari, E., Kirsch-Volders, M., Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis (2008) Mutat. Res., 651, pp. 30-39 | ||
| 504 | |a Vogt, E., Kirsch-Volders, M., Parry, J., Eichenlaub-Ritter, U., Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error (2008) Mutat. Res., 651, pp. 14-29 | ||
| 504 | |a McKarns, S.C., Hansch, C., Caldwell, W.S., Morgan, W.T., Moore, S.K., Doolittle, D.J., Correlation between hydrophobicity of short-chain aliphatic alcohols and their ability to alter plasma membrane integrity (1997) Fund. Appl. Toxicol., 36, pp. 62-70 | ||
| 504 | |a Crebelli, R., Contia, G., Contia, L., Carerea, A., A comparative study on ethanol and acetaldehyde as inducers of chromosome malsegregation in Aspergillus nidulans (1989) Mutat. Res., 215, pp. 187-195 | ||
| 504 | |a Muñoz, E.R., Effect of ethanol pretreatment on genetic damage induced by X-rays in Drosophila melanogaster sperm (1990) Mutat. Res., 232, pp. 3-10 | ||
| 504 | |a Palermo, A.M., Rey, M., Muñoz, E.R., Protective effect of ethanol on X-ray induced mitotic recombination in Drosophila melanogaster (1994) Environ. Mol. Mutagen., 24, pp. 137-142 | ||
| 504 | |a Rey, M., Palermo, A.M., Muñoz, E.R., Nondisjunction induced by ethanol in Drosophila melanogaster females (1992) Mutat. Res., 268, pp. 95-104 | ||
| 520 | 3 | |a Isopropanol (isopropyl alcohol, 2-propanol, IPA) is a volatile solvent widely used in domestic or industrial environments and reported as innocuous in various test systems. The aim of this work was to search for in vivo genotoxic effects of IPA in Drosophila melanogaster, studying its ability to induce nondisjunction (ND) in females, sex linked recessive lethals (SLRL) in males, and somatic mutation and/or recombination (SMART) in larvae. Treatments were acute (60. min) and were administered via inhalation. IPA had low toxicity in adult flies (75% IPA mortality index, MI = 12.7% (females) and 2.6% (males)) and larvae (MI = 14.3%, 75% IPA). Female fertility was severely affected during the first 24 h (brood I, BI) after treatment, but, afterwards, control values were recovered. IPA induced a 50-fold increase of ND (%) in 24 h old females, and a six-fold rise in 4-5 d old BI offspring. Nondisjunction frequencies (%) in the offspring of broods II to V (24 h in each case) were similar to control values. IPA doses of 25% and 50% (v/v), tested in 24 h old females, showed a significant dose-dependent increase of ND(%)in BI only, with control values in subsequent broods. Flies gave normal offspring when kept in regular media for 24 h before mating. The eye spot test (SMART) showed a significant increase at 50% IPA (p<0.05, m = 2), but the response was not dose-dependent. IPA failed to induce SLRL in any of the spermatogenesis stages tested. These findings suggest that the main effect of IPA is to induce chromosomal malsegregation; IPA must be present at the resumption of M-phase I after fertilization, to exert these effects. The alcohol does not affect DNA directly, but perturbations of the nuclear membrane may be responsible for induction of ND. © 2011 Elsevier B.V. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: We are indebted to Ms. Mabel N. Quevedo and Ms. Patricia Pereyra Schuth for their technical assistance. This research was partly supported by Consejo Nacional de Investigaciones Científicas y Técnicas ( CONICET ). | ||
| 593 | |a CITEDEF, J.B. de La Salle 4397, B1603ALO, Villa Martelli, Buenos Aires, Argentina | ||
| 593 | |a Grupo de Investigación en Biología Evolutiva (GIBE), FCEyN, UBA, Buenos Aires, Argentina | ||
| 593 | |a CONICET, Argentina | ||
| 690 | 1 | 0 | |a ANEUPLOIDY |
| 690 | 1 | 0 | |a DROSOPHILA MELANOGASTER |
| 690 | 1 | 0 | |a ISOPROPANOL (IPA) |
| 690 | 1 | 0 | |a MEIOTIC NON-DISJUNCTION (ND) |
| 690 | 1 | 0 | |a SEX LINKED RECESSIVE LETHALS (SLRL) |
| 690 | 1 | 0 | |a SOMATIC MUTATION AND RECOMBINATION (SMART) |
| 690 | 1 | 0 | |a 2 PROPANOL |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL CYCLE M PHASE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DROSOPHILA MELANOGASTER |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FEMALE FERTILITY |
| 690 | 1 | 0 | |a GENOTOXICITY |
| 690 | 1 | 0 | |a GERM CELL |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONDISJUNCTION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a SOMATIC CELL |
| 690 | 1 | 0 | |a SOMATIC MUTATION |
| 690 | 1 | 0 | |a SPERMATOGENESIS |
| 690 | 1 | 0 | |a 2-PROPANOL |
| 690 | 1 | 0 | |a ANEUPLOIDY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a DROSOPHILA MELANOGASTER |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENES, LETHAL |
| 690 | 1 | 0 | |a GERM CELLS |
| 690 | 1 | 0 | |a LARVA |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MUTAGENICITY TESTS |
| 690 | 1 | 0 | |a MUTAGENS |
| 690 | 1 | 0 | |a DROSOPHILA MELANOGASTER |
| 700 | 1 | |a Mudry, M.D. | |
| 773 | 0 | |d 2011 |g v. 726 |h pp. 215-221 |k n. 2 |p Mutat. Res. Genet. Toxicol. Environ. Mutagen. |x 13835718 |w (AR-BaUEN)CENRE-6178 |t Mutation Research - Genetic Toxicology and Environmental Mutagenesis | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_13835718_v726_n2_p215_Palermo |y Handle |
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