Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
In order to examine inhibitory effects of hexachlorobenzene metabolites on the hepatic porphyrinogen carboxylyase activity, rat liver cytosol was incubated with uroporphyrinogen III and chlorinated phenols, thiophenols, thioanisoles and benzenes. Then, the occurrence of hepta-, hexa-, penta- and tet...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1986
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03773caa a22005777a 4500 | ||
|---|---|---|---|
| 001 | PAPER-996 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203021.0 | ||
| 008 | 190411s1986 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0022620348 | |
| 024 | 7 | |2 cas |a hexachlorobenzene, 118-74-1, 55600-34-5; pentachlorophenol, 87-86-5; tetrachlorohydroquinone, 87-87-6; uroporphyrinogen decarboxylase, 9024-70-8; Carboxy-Lyases, EC 4.1.1.; Chlorobenzenes; Chlorophenols; Hexachlorobenzene, 118-74-1; pentachlorobenzene, 608-93-5; porphyrinogen carboxy-lyase, EC 4.1.1.-; Uroporphyrinogens | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a RCOCB | ||
| 100 | 1 | |a Billi, S.C. | |
| 245 | 1 | 0 | |a Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase |
| 260 | |c 1986 | ||
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a In order to examine inhibitory effects of hexachlorobenzene metabolites on the hepatic porphyrinogen carboxylyase activity, rat liver cytosol was incubated with uroporphyrinogen III and chlorinated phenols, thiophenols, thioanisoles and benzenes. Then, the occurrence of hepta-, hexa-, penta- and tetracarboxyporphyrinogen = coproporphyrinogen (measured as porphyrins) was determined. - Inhibitory effects were exerted by tetrachlorohydroquinone, pentachlorophenol, pentachlorothiophenol, 1,2,3,5- and 1,2,4,5- tetrachlorobenzene. Other compounds including hexachlorobenzene which was tested for comparative reasons did not impair uroporphyrinogen decarboxylation. - In the presence of tetrachlorohydroquinone, uroporphyrinogen merely was decarboxylated to hepta- and hexacarboxyporphyrinogen. Under the influence of the other 4 compounds with inhibitory effects, pentacarboxyporphyrinogen and coproporphyrinogen were formed additionally. - Coproporphyrinogen formation was inhibited completely by tetrachlorohydroquinone, while pentachlorophenol diminished its formation by about 50% and pentachlorothiophenol, 1,2,3,5- and 1,2,4,5-tetrachlorobenzene by less than 10%. |l eng | |
| 593 | |a Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a PENTACHLOROPHENOL |
| 690 | 1 | 0 | |a TETRACHLOROHYDROQUINONE |
| 690 | 1 | 0 | |a UROPORPHYRINOGEN DECARBOXYLASE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a METABOLITE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PENTACHLOROBENZENETHIOL |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a TETRACHLOROBENZENE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CARBOXY-LYASES |
| 690 | 1 | 0 | |a CHLOROBENZENES |
| 690 | 1 | 0 | |a CHLOROPHENOLS |
| 690 | 1 | 0 | |a CYTOSOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a UROPORPHYRINOGENS |
| 700 | 1 | |a Koss, G. | |
| 700 | 1 | |a San Martin de Viale, L.C. | |
| 773 | 0 | |d 1986 |g v. 51 |h pp. 325-336 |k n. 3 |p RES. COMMUN. CHEM. PATHOL. PHARMACOL. |x 00345164 |t Research Communications in Chemical Pathology and Pharmacology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022620348&partnerID=40&md5=45ed7e28b8f04d30e6063ec93e0349ce |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00345164_v51_n3_p325_Billi |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi |y Registro en la Biblioteca Digital |
| 961 | |a paper_00345164_v51_n3_p325_Billi |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 61949 | ||