Staufen: From embryo polarity to cellular stress and neurodegeneration

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Staufen is a double-stranded RNA-binding protein that forms RNA granules by RNA-dependent and - independent interactions. Staufen was initially described in Drosophila as a key molecule for targeting maternal mRNAs. In vertebrates, two highly similar paralogs with several splicing variants mediate m...

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Detalles Bibliográficos
Autor principal: Tosar, L.J.M
Otros Autores: Thomas, M.G, Baez, M.V, Ibanez, I., Chernomoretz, A., Boccaccio, G.L
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2012
Materias:
VIRUS RNA
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 cas  |a huntingtin, 191683-04-2; RNA, 63231-63-0; RNA, 63231-63-0; RNA, Messenger; RNA-Binding Proteins; Ribonucleoproteins; messenger ribonucleoprotein 
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100 1 |a Tosar, L.J.M. 
245 1 0 |a Staufen: From embryo polarity to cellular stress and neurodegeneration 
260 |c 2012 
270 1 0 |m Boccaccio, G.L.; Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE-Buenos Aires, Argentina; email: gboccaccio@leloir.org.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Staufen is a double-stranded RNA-binding protein that forms RNA granules by RNA-dependent and - independent interactions. Staufen was initially described in Drosophila as a key molecule for targeting maternal mRNAs. In vertebrates, two highly similar paralogs with several splicing variants mediate mRNA transport, thus affecting neuron plasticity, learning and memory. Staufen also regulates translation and mRNA decay. In recent years, Staufen was shown to be an important regulatory component of stress granules (SGs), which are large aggregates of silenced mRNPs specifically induced upon acute cellular stress. SGs contribute to cell survival by reprogramming translation and inhibiting pro-apoptotic pathways, and Staufen appears to negatively modulate SG formation by several mechanisms. More recently, mammalian Staufen was found in RNA granules and pathological cytoplasmic aggregates related to SGs containing huntingtin, TDP43, FUS/TLS or FMRP. In addition, Staufen binds CUG repeats present in mutant RNAs causative of degenerative conditions, thus ameliorating disease. Finally, Staufen affects HIV and influenza infection at several levels. Collectively, these observations unveil important roles for Staufen-mediated post-transcriptional regulation in a growing number of human diseases.  |l eng 
536 |a Detalles de la financiación: National Institutes of Health, NIH, UBACyTX834 
593 |a Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE-Buenos Aires, Argentina 
593 |a IIBBA-CONICET, C1405BWE-Buenos Aires, Argentina 
593 |a Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina 
593 |a IBCN, CONICET, Facultad de Medicina, University of Buenos Aires, Argentina 
593 |a IFIBA, CONICET, Argentina 
690 1 0 |a FMRP 
690 1 0 |a FUS/TLS/HNRNP P2 
690 1 0 |a HIV 
690 1 0 |a HUNTINGTIN 
690 1 0 |a INFLUENZA VIRUS 
690 1 0 |a MEMORY 
690 1 0 |a MRNA TRANSPORT 
690 1 0 |a NEURODEGENERATION 
690 1 0 |a NEURON 
690 1 0 |a OLIGODENDROCYTE 
690 1 0 |a REVIEW 
690 1 0 |a SCA8 
690 1 0 |a STAUFEN 
690 1 0 |a STRESS GRANULES 
690 1 0 |a TDP-43 
690 1 0 |a APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G 
690 1 0 |a DOUBLE STRANDED RNA 
690 1 0 |a FRAGILE X MENTAL RETARDATION PROTEIN 
690 1 0 |a FUSED IN SARCOMA PROTEIN 
690 1 0 |a HUNTINGTIN 
690 1 0 |a MESSENGER RNA 
690 1 0 |a NUCLEIC ACID BINDING PROTEIN 
690 1 0 |a PROTEIN KINASE R 
690 1 0 |a RIBONUCLEOPROTEIN 
690 1 0 |a RNA BINDING PROTEIN 
690 1 0 |a SPINOCEREBELLAR ATAXIA 8 PROTEIN 
690 1 0 |a STAUFEN 1 PROTEIN 
690 1 0 |a STAUFEN 2 PROTEIN 
690 1 0 |a TAR DNA BINDING PROTEIN 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a VIRUS PROTEIN 
690 1 0 |a MESSENGER RIBONUCLEOPROTEIN 
690 1 0 |a MESSENGER RNA 
690 1 0 |a RIBONUCLEOPROTEIN 
690 1 0 |a RNA 
690 1 0 |a RNA BINDING PROTEIN 
690 1 0 |a ALTERNATIVE RNA SPLICING 
690 1 0 |a ARTICLE 
690 1 0 |a CELL GRANULE 
690 1 0 |a CELL STRESS 
690 1 0 |a CELL SURVIVAL 
690 1 0 |a CELLULAR DISTRIBUTION 
690 1 0 |a DENDRITE 
690 1 0 |a DENDRITIC SPINE 
690 1 0 |a DROSOPHILA 
690 1 0 |a DUCHENNE MUSCULAR DYSTROPHY 
690 1 0 |a EMBRYO POLARITY 
690 1 0 |a ENZYME ACTIVATION 
690 1 0 |a ENZYME ACTIVITY 
690 1 0 |a GENE DELETION 
690 1 0 |a GENE OVEREXPRESSION 
690 1 0 |a GENE SILENCING 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN IMMUNODEFICIENCY VIRUS 1 
690 1 0 |a INFLUENZA VIRUS A 
690 1 0 |a LEARNING 
690 1 0 |a MEMORY 
690 1 0 |a MORPHOGENESIS 
690 1 0 |a MYOTONIC DYSTROPHY 
690 1 0 |a NERVE CELL PLASTICITY 
690 1 0 |a NERVE DEGENERATION 
690 1 0 |a NONHUMAN 
690 1 0 |a NUCLEOTIDE REPEAT 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a OXIDATIVE STRESS 
690 1 0 |a POLYSOME 
690 1 0 |a PROTEIN SYNTHESIS 
690 1 0 |a RNA BINDING 
690 1 0 |a RNA SILENCING 
690 1 0 |a RNA STABILITY 
690 1 0 |a RNA STRUCTURE 
690 1 0 |a RNA TRANSPORT 
690 1 0 |a SPINE 
690 1 0 |a SPINE MORPHOGENESIS 
690 1 0 |a SPINOCEREBELLAR ATAXIA 2 
690 1 0 |a SPINOCEREBELLAR DEGENERATION 
690 1 0 |a STRESS GRANULE 
690 1 0 |a SYNAPSE 
690 1 0 |a TRANSLATION REGULATION 
690 1 0 |a VERTEBRATE 
690 1 0 |a VIRUS ASSEMBLY 
690 1 0 |a VIRUS PARTICLE 
690 1 0 |a ANIMAL 
690 1 0 |a GENETICS 
690 1 0 |a METABOLISM 
690 1 0 |a PHYSIOLOGY 
690 1 0 |a REVIEW 
690 1 0 |a ANIMALS 
690 1 0 |a HUMANS 
690 1 0 |a RIBONUCLEOPROTEINS 
690 1 0 |a RNA 
690 1 0 |a RNA STABILITY 
690 1 0 |a RNA TRANSPORT 
690 1 0 |a RNA, MESSENGER 
690 1 0 |a RNA-BINDING PROTEINS 
650 1 7 |2 spines  |a VIRUS RNA 
700 1 |a Thomas, M.G. 
700 1 |a Baez, M.V. 
700 1 |a Ibanez, I. 
700 1 |a Chernomoretz, A. 
700 1 |a Boccaccio, G.L. 
773 0 |d 2012  |g v. 4 S  |h pp. 432-452  |k n. 2  |p Front. Biosci. Sch.  |x 19450516  |t Frontiers in Bioscience - Scholar 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863301956&partnerID=40&md5=a3cb8988c12d4c651b053847e107b3ac  |y Registro en Scopus 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_19450516_v4S_n2_p432_Tosar  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450516_v4S_n2_p432_Tosar  |y Registro en la Biblioteca Digital 
961 |a paper_19450516_v4S_n2_p432_Tosar  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 70884 

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