Lysine transporters in human trypanosomatid pathogens
In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these par...
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2012
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| 024 | 7 | |2 scopus |a 2-s2.0-84860246976 | |
| 024 | 7 | |2 Molecular Sequence Numbers |a GENBANK: AAC49885, AAD40315, ABD64602, CAA47729, NP_058913, NP_072141, NP_175076, NP_193844, NP_199774, NP_416661, NP_600195, P19145, XP_714306, XP_859317; | |
| 024 | 7 | |2 cas |a alanine, 56-41-7, 6898-94-8; arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; asparagine, 70-47-3, 7006-34-0; aspartic acid, 56-84-8, 6899-03-2; cysteine, 4371-52-2, 52-89-1, 52-90-4; glycine, 56-40-6, 6000-43-7, 6000-44-8; histidine, 645-35-2, 7006-35-1, 71-00-1; lysine, 56-87-1, 6899-06-5, 70-54-2; methionine, 59-51-8, 63-68-3, 7005-18-7; proline, 147-85-3, 7005-20-1; serine, 56-45-1, 6898-95-9; threonine, 36676-50-3, 72-19-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a AACIE | ||
| 100 | 1 | |a Inbar, E. | |
| 245 | 1 | 0 | |a Lysine transporters in human trypanosomatid pathogens |
| 260 | |c 2012 | ||
| 270 | 1 | 0 | |m Zilberstein, D.; Faculty of Biology, Technion-Israel Institute of Technology, 32000 Haifa, Israel; email: danz@tx.technion.ac.il |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters translocate only arginine. This phenomenon prompted us to identify and characterize parasite lysine transporters. Here we demonstrate that LdAAP7 and TcAAP7 encode lysine-specific permeases in L. donovani and T. cruzi, respectively. These two lysine permeases are both members of the large amino acid/auxin permease family and share certain biochemical properties, such as specificity and Km. However, we evidence that LdAAP7 and TcAAP7 differ in their regulation and localization, such differences are likely a reflection of the dissimilar L. donovani and T. cruzi life cycles. Failed attempts to delete both alleles of LdAAP7 support the premise that this is an essential gene that encodes the only lysine permeases expressed in L. donovani promastigotes and T. cruzi epimastigotes, respectively. © Springer-Verlag 2010. |l eng | |
| 593 | |a Faculty of Biology, Technion-Israel Institute of Technology, 32000 Haifa, Israel | ||
| 593 | |a Departamento de Sustancias Vasoactivas, Laboratorio de Biología Molecular de Trypanosoma Cruzi (LBMTC), Instituto de Investigaciones Médicas Alfredo Lanari, Buenos Aires, Argentina | ||
| 593 | |a Fundación Instituto Leloir, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and CONICET, Buenos Aires, Argentina | ||
| 593 | |a Institute of Plant Sciences, University of Bern, 3013 Bern, Switzerland | ||
| 690 | 1 | 0 | |a AMINO ACID TRANSPORT |
| 690 | 1 | 0 | |a LEISHMANIA |
| 690 | 1 | 0 | |a LYSINE TRANSPORT |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a ALANINE |
| 690 | 1 | 0 | |a AMINO ACID TRANSPORTER |
| 690 | 1 | 0 | |a ARGININE |
| 690 | 1 | 0 | |a ASPARAGINE |
| 690 | 1 | 0 | |a ASPARTIC ACID |
| 690 | 1 | 0 | |a AUXIN |
| 690 | 1 | 0 | |a CYSTEINE |
| 690 | 1 | 0 | |a GLYCINE |
| 690 | 1 | 0 | |a HISTIDINE |
| 690 | 1 | 0 | |a LEISHMANIA DONOVANI AAP7 |
| 690 | 1 | 0 | |a LYSINE |
| 690 | 1 | 0 | |a LYSINE TRANSPORTER |
| 690 | 1 | 0 | |a METHIONINE |
| 690 | 1 | 0 | |a PERMEASE |
| 690 | 1 | 0 | |a PROLINE |
| 690 | 1 | 0 | |a SERINE |
| 690 | 1 | 0 | |a THREONINE |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI AAP7 |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a CONFERENCE PAPER |
| 690 | 1 | 0 | |a ENZYME KINETICS |
| 690 | 1 | 0 | |a ENZYME REGULATION |
| 690 | 1 | 0 | |a ENZYME SPECIFICITY |
| 690 | 1 | 0 | |a EPIMASTIGOTE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IMMUNOFLUORESCENCE TEST |
| 690 | 1 | 0 | |a LEISHMANIA DONOVANI |
| 690 | 1 | 0 | |a LIFE CYCLE |
| 690 | 1 | 0 | |a NUCLEOTIDE SEQUENCE |
| 690 | 1 | 0 | |a OPEN READING FRAME |
| 690 | 1 | 0 | |a PARASITE SURVIVAL |
| 690 | 1 | 0 | |a PHYLOGENY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROMASTIGOTE |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN LOCALIZATION |
| 690 | 1 | 0 | |a SACCHAROMYCES CEREVISIAE |
| 690 | 1 | 0 | |a SEQUENCE ANALYSIS |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPANOSOMATID INFECTION |
| 690 | 1 | 0 | |a EUKARYOTA |
| 690 | 1 | 0 | |a LEISHMANIA DONOVANI |
| 690 | 1 | 0 | |a NASO HEXACANTHUS |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPANOSOMATIDAE |
| 700 | 1 | |a Canepa, G.E. | |
| 700 | 1 | |a Carrillo, C. | |
| 700 | 1 | |a Glaser, F. | |
| 700 | 1 | |a Grotemeyer, M.S. | |
| 700 | 1 | |a Rentsch, D. | |
| 700 | 1 | |a Zilberstein, D. | |
| 700 | 1 | |a Pereira, C.A. | |
| 773 | 0 | |d 2012 |g v. 42 |h pp. 347-360 |k n. 1 |p Amino Acids |x 09394451 |t Amino Acids | |
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