Cytogenetic and microtubule array effects of the zineb-containing commercial fungicide formulation Azzurro ® on meristematic root cells of Allium cepa L.
Zineb [ethylene bis(dithiocarbamate) zinc] is a widely employed foliar fungicide for agricultural and industrial applications. Allium cepa L. is a reliable model for the assessment of xenobiotic genotoxicity and cytotoxicity. We evaluated the effects of the zineb-containing commercial formulation Az...
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2012
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| 008 | 190411s2012 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84856216980 | |
| 024 | 7 | |2 cas |a zineb, 12122-67-7; Fungicides, Industrial; Zineb, 12122-67-7; azzurro | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MRGMF | ||
| 100 | 1 | |a Andrioli, N.B. | |
| 245 | 1 | 0 | |a Cytogenetic and microtubule array effects of the zineb-containing commercial fungicide formulation Azzurro ® on meristematic root cells of Allium cepa L. |
| 260 | |c 2012 | ||
| 270 | 1 | 0 | |m Andrioli, N.B.; Grupo de Investigación en Biología Evolutiva (GIBE), Facultad de Ciencias Exactas y Naturales, UBA, Intendente Güiraldes 2160, Ciudad Universitaria, C1428EGA Ciudad Autónoma de Buenos Aires, Argentina; email: nandrioli@hotmail.com |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a González, M., Soloneski, S., Reigosa, M.A., Larramendy, M.L., Effect of dithiocarbamate pesticide zineb and its commercial formulation azzurro. IV. DNA damage and repair kinetic assessed by single cell gel electrophoresis (SCGE) assay on Chinese hamster ovary (CHO) cells (2003) Mutat. Res., 534, pp. 145-154 | ||
| 504 | |a Soloneski, S., Reigosa, M.A., Larramendy, M.L., Effect of dithiocarbamate pesticide zineb and its commercial formulation azzurro. II. Clastogenesis on immunophenotyped human lymphocytes assessed by the micronucleus test (2002) Environ. Mol. Mutagen., 40, pp. 57-62 | ||
| 504 | |a McDonald, A.R., Liu, B., Joshi, H.C., Palevitz, B.A., γ-Tubulin is associated with a cortical-microtubule-organizing zone in the developing guard cells of Allium cepa L (1993) Planta, 191, pp. 357-361 | ||
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| 520 | 3 | |a Zineb [ethylene bis(dithiocarbamate) zinc] is a widely employed foliar fungicide for agricultural and industrial applications. Allium cepa L. is a reliable model for the assessment of xenobiotic genotoxicity and cytotoxicity. We evaluated the effects of the zineb-containing commercial formulation Azzurro ® (70% zineb) in cell cycle stages of the meristem root cells of A. cepa. The mitotic index (MI), chromosomal aberrations at anaphase/telophase (CAs), micronuclei (MN), and abnormalities in immunodetected microtubule structures, e.g., preprophasic band (PPB), mitotic spindle (MS), and phragmoplast (Phrag), were used as end-points. Azzurro ® (1 and 10μg/ml) induced a significant increase in the frequency of CAs (P<0.05), and the higher concentration inhibited the MI (P<0.05) compared to control values. The frequency of MN did not differ from control values at any concentration. Treatment with 1μg/ml Azzurro ® induced a significant increase in the frequency of abnormal PPB (P<0.01), MS (P<0.001), and Phrag (P<0.01) and, at 10μg/ml, enhancements in the frequencies of abnormal MS (P<0.05) and Phrag (P<0.05) were seen. A tubulin immunodetection assay showed that exposure to Azzurro ® interferes with normal assembly of microtubule structures during mitosis. © 2011 Elsevier B.V. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, MDM-UBACyT X154 | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research | ||
| 536 | |a Detalles de la financiación: Universidad Nacional de La Plata, UNLP, 11/N619, 11/N564 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP No 0744, PIP No 0106 | ||
| 536 | |a Detalles de la financiación: This study was supported by grants from the National University of La Plata (Grants 11/N564 , 11/N619 ), the University of Buenos Aires (Grant MDM-UBACyT X154), and the National Council for Scientific and Technological Research (CONICET, Grants PIP No 0106, PIP No 0744) from Argentina. | ||
| 593 | |a Grupo de Investigación en Biología Evolutiva (GIBE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160 - Ciudad Universitaria, C1428EGA Buenos Aires, Argentina | ||
| 593 | |a Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, Calle 64 N 3, B1904AMA La Plata, Argentina | ||
| 593 | |a CONICET, Argentina | ||
| 690 | 1 | 0 | |a ALLIUM CEPA |
| 690 | 1 | 0 | |a CYTOTOXICITY |
| 690 | 1 | 0 | |a GENOTOXICITY |
| 690 | 1 | 0 | |a MICROTUBULES |
| 690 | 1 | 0 | |a ZINEB |
| 690 | 1 | 0 | |a ZINEB |
| 690 | 1 | 0 | |a ANAPHASE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL CYCLE |
| 690 | 1 | 0 | |a CHROMOSOME ABERRATION |
| 690 | 1 | 0 | |a CONCENTRATION (PARAMETERS) |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOGENETICS |
| 690 | 1 | 0 | |a GENOTOXICITY |
| 690 | 1 | 0 | |a MICRONUCLEUS |
| 690 | 1 | 0 | |a MICROTUBULE |
| 690 | 1 | 0 | |a MITOSIS INDEX |
| 690 | 1 | 0 | |a MITOSIS SPINDLE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a ONION |
| 690 | 1 | 0 | |a PHRAGMOPLAST |
| 690 | 1 | 0 | |a PLANT CELL |
| 690 | 1 | 0 | |a PLANT ROOT |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a TELOPHASE |
| 690 | 1 | 0 | |a ALLIUM |
| 690 | 1 | 0 | |a CELL CYCLE |
| 690 | 1 | 0 | |a CHROMOSOME ABERRATIONS |
| 690 | 1 | 0 | |a FUNGICIDES, INDUSTRIAL |
| 690 | 1 | 0 | |a MERISTEM |
| 690 | 1 | 0 | |a MICRONUCLEI, CHROMOSOME-DEFECTIVE |
| 690 | 1 | 0 | |a MICROTUBULES |
| 690 | 1 | 0 | |a MITOTIC INDEX |
| 690 | 1 | 0 | |a MITOTIC SPINDLE APPARATUS |
| 690 | 1 | 0 | |a PLANT ROOTS |
| 690 | 1 | 0 | |a ZINEB |
| 690 | 1 | 0 | |a ALLIUM CEPA |
| 700 | 1 | |a Soloneski, S. | |
| 700 | 1 | |a Larramendy, M.L. | |
| 700 | 1 | |a Mudry, M.D. | |
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