Involvement of TSSA (trypomastigote small surface antigen) in Trypanosoma cruzi invasion of mammalian cells 1
TSSA (trypomastigote small surface antigen) is a polymorphic mucin-like molecule displayed on the surface of Trypanosoma cruzi trypomastigote forms. To evaluate its functional properties, we undertook comparative biochemical and genetic approaches on isoforms present in parasite stocks from extant e...
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2012
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| LEADER | 16174caa a22014657a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518203931.0 | ||
| 008 | 190411s2012 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84860879179 | |
| 024 | 7 | |2 Molecular Sequence Numbers |a GENBANK: AF036421, AF036443, JN596089, JN596094, JQ354939; | |
| 024 | 7 | |2 cas |a calcium ion, 14127-61-8; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; Variant Surface Glycoproteins, Trypanosoma; trypomastigote small surface antigen, Trypanosoma cruzi | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BIJOA | ||
| 100 | 1 | |a Cánepa, G.E. | |
| 245 | 1 | 0 | |a Involvement of TSSA (trypomastigote small surface antigen) in Trypanosoma cruzi invasion of mammalian cells 1 |
| 260 | |c 2012 | ||
| 270 | 1 | 0 | |m Buscaglia, C.A.; Instituto de Investigaciones Biotecnologicas-Instituto Tecnologico de Chascomus (IIB-INTECh), Universidad Nacional de San Martín (UNSAM)-CONICET, Predio INTI, Av. Gral Paz y Albarellos, San Martín, Buenos Aires, Argentina; email: cbusca@iib.unsam.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Buscaglia, C.A., Campo, V.A., Di, N.J.M., Torrecilhas, A.C.T., De Marchi, C.R., Ferguson, M.A.J., Frasch, A.C.C., Almeida, I.C., The Surface Coat of the Mammal-dwelling Infective Trypomastigote Stage of Trypanosoma cruzi Is Formed by Highly Diverse Immunogenic Mucins (2004) Journal of Biological Chemistry, 279 (16), pp. 15860-15869. , DOI 10.1074/jbc.M314051200 | ||
| 504 | |a De Marchi, C.R., Di Noia, J.M., Frasch, A.C., Amato Neto, V., Almeida, I.C., Buscaglia, C.A., Evaluation of a recombinant Trypanosoma cruzi mucin-like antigen for serodiagnosis of Chagas' disease (2011) Clin. Vaccine Immunol., 18, pp. 1850-1855 | ||
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| 504 | |a Urban, I., Santurio, L.B., Chidichimo, A., Yu, H., Chen, X., Mucci, J., Agüero, F., Buscaglia, C.A., Molecular diversity of the Trypanosoma cruzi TcSMUG family of mucin genes and proteins (2011) Biochem. J., 438, pp. 303-313 | ||
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| 520 | 3 | |a TSSA (trypomastigote small surface antigen) is a polymorphic mucin-like molecule displayed on the surface of Trypanosoma cruzi trypomastigote forms. To evaluate its functional properties, we undertook comparative biochemical and genetic approaches on isoforms present in parasite stocks from extant evolutionary lineages (CL Brener and Sylvio X-10). We show that CL Brener TSSA, but not the Sylvio X-10 counterpart, exhibits dosedependent and saturable binding towards non-macrophagic cell lines. This binding triggers Ca 2+ -based signalling responses in the target cell while providing an anchor for the invading parasite.Accordingly, exogenous addition of either TSSA-derived peptides or specific antibodies significantly inhibits invasion of CL Brener, but not Sylvio X-10, trypomastigotes. Non-infective epimastigote forms, which do not express detectable levels of TSSA, were stably transfected with TSSA cDNA from either parasite stock. Although both transfectants produced a surfaceassociated mucin-like TSSA product, epimastigotes expressing CL Brener TSSA showed a ∼2-fold increase in their attachment to mammalian cells. Overall, these findings indicate that CL Brener TSSA functions as a parasite adhesin, engaging surface receptor(s) and inducing signalling pathways on the host cell as a prerequisite for parasite internalization. More importantly, the contrasting functional features of TSSA isoforms provide one appealing mechanism underlying the differential infectivity of T. cruzi stocks. © The Authors Journal compilation © 2012 Biochemical Society. |l eng | |
| 593 | |a Instituto de Investigaciones Biotecnologicas-Instituto Tecnologico de Chascomus (IIB-INTECh), Universidad Nacional de San Martín (UNSAM)-CONICET, Predio INTI, Av. Gral Paz y Albarellos, San Martín, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA)-CONICET, Intendente Güiraldes 2160, Ciudad Universitaria, Buenos Aires, Argentina | ||
| 593 | |a Universidade de São Paulo, Departamento de Parasitologia, Instituto de Biociências, Cidade Universitária, 05508-900 São Paulo, Brazil | ||
| 690 | 1 | 0 | |a CALCIUM |
| 690 | 1 | 0 | |a CELL INVASION |
| 690 | 1 | 0 | |a MUCIN |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPOMASTIGOTE SMALL SURFACE ANTIGEN (TSSA) |
| 690 | 1 | 0 | |a CALCIUM ION |
| 690 | 1 | 0 | |a COMPLEMENTARY DNA |
| 690 | 1 | 0 | |a MEMBRANE ANTIGEN |
| 690 | 1 | 0 | |a MITOGEN ACTIVATED PROTEIN KINASE 1 |
| 690 | 1 | 0 | |a MITOGEN ACTIVATED PROTEIN KINASE 3 |
| 690 | 1 | 0 | |a MUCIN |
| 690 | 1 | 0 | |a PARASITE ANTIBODY |
| 690 | 1 | 0 | |a PARASITE ANTIGEN |
| 690 | 1 | 0 | |a TRYPOMASTIGOTE SMALL SURFACE ANTIGEN |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BINDING AFFINITY |
| 690 | 1 | 0 | |a CALCIUM SIGNALING |
| 690 | 1 | 0 | |a CELL ADHESION |
| 690 | 1 | 0 | |a CELL INVASION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EPIMASTIGOTE |
| 690 | 1 | 0 | |a GENETIC TRANSFECTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a INTERNALIZATION |
| 690 | 1 | 0 | |a MAMMAL CELL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NUCLEOTIDE SEQUENCE |
| 690 | 1 | 0 | |a PHAGOCYTOSIS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN BINDING |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a TARGET CELL |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPOMASTIGOTE |
| 690 | 1 | 0 | |a AMINO ACID SEQUENCE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a HEK293 CELLS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a PROTEIN BINDING |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA |
| 690 | 1 | 0 | |a VERO CELLS |
| 690 | 1 | 0 | |a MAMMALIA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 700 | 1 | |a Degese, M.S. | |
| 700 | 1 | |a Budu, A. | |
| 700 | 1 | |a Garcia, C.R.S. | |
| 700 | 1 | |a Buscaglia, C.A. | |
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