Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas

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Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia induc...

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Autor principal: Shan, B.
Otros Autores: Schaaf, C., Schmidt, A., Lucia, K., Buchfelder, M., Losa, M., Kuhlen, D., Kreutzer, J., Perone, M.J, Arzt, E., Stalla, G.K, Renner, U.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2012
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-84866295392 
024 7 |2 cas  |a curcumin, 458-37-7; vasculotropin, 127464-60-2; vasculotropin A, 489395-96-2; Antineoplastic Agents; Curcumin, 458-37-7; HIF1A protein, human; Hypoxia-Inducible Factor 1, alpha Subunit; RNA, Messenger; VEGFA protein, human; Vascular Endothelial Growth Factor A 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a JOENA 
100 1 |a Shan, B. 
245 1 0 |a Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas 
260 |c 2012 
270 1 0 |m Renner, U.; Neuroendocrinology Group, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany; email: renner@mpipsykl.mpg.de 
506 |2 openaire  |e Política editorial 
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504 |a Pagotto, U., Arzberger, T., Theodoropoulou, M., Grübler, Y., Pantaloni, C., Saeger, W., Losa, M., Spengler, D., The expression of the antiproliferative gene ZAC is lost or highly reduced in non-functioning pituitary adenomas (2000) Cancer Research, 60, pp. 6794-6799 
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520 3 |a Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1α (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (nZ32) studied. Under hypoxia-mimicking conditions (CoCl 2 treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (nZ8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1. Curcumin also blocked hypoxiainducedmRNAsynthesis and secretion ofVEGFAinGH3 cells and in all human pituitary adenoma cell cultures investigated (nZ18). Thus, curcumin may inhibit pituitary adenoma progression not only through previously demonstrated antiproliferative and pro-apoptotic actions but also by its suppressive effects on pituitary tumour neovascularisation. © 2012 Society for Endocrinology.  |l eng 
593 |a Neuroendocrinology Group, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany 
593 |a Department of Neurosurgery, University of Erlangen-Nuremburg, Schwabachanlage 6, 91594 Erlangen, Germany 
593 |a Department of Neurosurgery, Istituto San Raffaele, Via Olgettina 60, 20132 Milano, Italy 
593 |a Department of Neurosurgery, Technical University Munich, Ismaninger Straße 22, 81675 Munich, Germany 
593 |a Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiologi y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 
593 |a IBioBA-CONICET, Max Planck Partner Institute, RA-1428 Buenos Aires, Argentina 
690 1 0 |a CURCUMIN 
690 1 0 |a HYPOXIA INDUCIBLE FACTOR 1ALPHA 
690 1 0 |a MESSENGER RNA 
690 1 0 |a VASCULOTROPIN 
690 1 0 |a VASCULOTROPIN A 
690 1 0 |a ADULT 
690 1 0 |a AGED 
690 1 0 |a ANGIOGENESIS 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ARTICLE 
690 1 0 |a FEMALE 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a HYPOPHYSIS ADENOMA 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a MALE 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN SECRETION 
690 1 0 |a PROTEIN SYNTHESIS 
690 1 0 |a RAT 
690 1 0 |a REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION 
690 1 0 |a WESTERN BLOTTING 
690 1 0 |a ADENOMA 
690 1 0 |a ANIMALS 
690 1 0 |a ANTINEOPLASTIC AGENTS 
690 1 0 |a CELL HYPOXIA 
690 1 0 |a CELL LINE, TUMOR 
690 1 0 |a CORTICOTROPHS 
690 1 0 |a CURCUMIN 
690 1 0 |a HUMANS 
690 1 0 |a HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT 
690 1 0 |a LACTOTROPHS 
690 1 0 |a MICE 
690 1 0 |a NEOVASCULARIZATION, PATHOLOGIC 
690 1 0 |a PITUITARY NEOPLASMS 
690 1 0 |a RATS 
690 1 0 |a RNA, MESSENGER 
690 1 0 |a SOMATOTROPHS 
690 1 0 |a VASCULAR ENDOTHELIAL GROWTH FACTOR A 
700 1 |a Schaaf, C. 
700 1 |a Schmidt, A. 
700 1 |a Lucia, K. 
700 1 |a Buchfelder, M. 
700 1 |a Losa, M. 
700 1 |a Kuhlen, D. 
700 1 |a Kreutzer, J. 
700 1 |a Perone, M.J. 
700 1 |a Arzt, E. 
700 1 |a Stalla, G.K. 
700 1 |a Renner, U. 
773 0 |d 2012  |g v. 214  |h pp. 389-398  |k n. 3  |p J. Endocrinol.  |x 00220795  |t Journal of Endocrinology 
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