Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models
A classical view of the neuroendocrine-immune network assumes bidirectional interactions where pro-inflammatory cytokines influence hypothalamic-pituitary- adrenal (HPA) axis-derived hormones that subsequently affect cytokines in a permanently servo-controlled circle. Nevertheless, this picture has...
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| Formato: | Capítulo de libro |
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Blackwell Publishing Inc.
2009
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| 024 | 7 | |2 cas |a beta endorphin, 59887-17-1; corticotropin releasing factor, 9015-71-8, 178359-01-8, 79804-71-0, 86297-72-5, 86784-80-7; mitogen activated protein kinase, 142243-02-5 | |
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| 100 | 1 | |a Silberstein, S. | |
| 245 | 1 | 0 | |a Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models |
| 260 | |b Blackwell Publishing Inc. |c 2009 | ||
| 270 | 1 | 0 | |m Arzt, E.; Laboratorio de Fisiología Y Biología Molecular, FCEN, Ciudad Universitaria, 1428 Buenos Aires, Argentina; email: earzt@fbmc.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a A classical view of the neuroendocrine-immune network assumes bidirectional interactions where pro-inflammatory cytokines influence hypothalamic-pituitary- adrenal (HPA) axis-derived hormones that subsequently affect cytokines in a permanently servo-controlled circle. Nevertheless, this picture has been continuously evolving over the last years as a result of the discovery of redundant expression and extended functions of many of the molecules implicated. Thus, cytokines are not only expressed in cells of the immune system but also in the central nervous system, and many hormones present at hypothalamic- pituitary level are also functionally expressed in the brain as well as in other peripheral organs, including immune cells. Because of this intermingled network of molecules redundantly expressed, the elucidation of the unique roles of HPA axis-related molecules at every level of complexity is one of the major challenges in the field. Genetic engineering in the mouse offers the most convincing method for dissecting in vivo the specific roles of distinct molecules acting in complex networks. Thus, various immunological, behavioral, and signal transduction studies performed with different HPA axis-related mutant mouse lines to delineate the roles of β-endorphin, the type 1 receptor of corticotropin-releasing hormone (CRHR1), and its ligand CRH will be discussed here. © 2009 New York Academy of Sciences. |l eng | |
| 593 | |a Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología Y Biología Molecular Y Celular, IFYBINE: Inst. de Fisiol., Biol. Molec. Y Neurociencias-Consejo Nac. de Invest. Cie. Y Tecnicas, Buenos Aires, Argentina | ||
| 593 | |a Max-Planck Institute of Psychiatry, Munich, Germany | ||
| 593 | |a Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany | ||
| 593 | |a Max-Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany | ||
| 593 | |a Laboratorio de Fisiología Y Biología Molecular, FCEN, Ciudad Universitaria, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BEHAVIOR |
| 690 | 1 | 0 | |a CRF |
| 690 | 1 | 0 | |a CRH |
| 690 | 1 | 0 | |a ERK |
| 690 | 1 | 0 | |a FORCED SWIM TEST |
| 690 | 1 | 0 | |a HPA AXIS |
| 690 | 1 | 0 | |a MAPK |
| 690 | 1 | 0 | |a MOUSE MODELS |
| 690 | 1 | 0 | |a STRESS |
| 690 | 1 | 0 | |a STRESS-COPING BEHAVIOR |
| 690 | 1 | 0 | |a Β-ENDORPHIN |
| 690 | 1 | 0 | |a BETA ENDORPHIN |
| 690 | 1 | 0 | |a CORTICOTROPIN RELEASING FACTOR |
| 690 | 1 | 0 | |a CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 |
| 690 | 1 | 0 | |a CYTOKINE |
| 690 | 1 | 0 | |a MITOGEN ACTIVATED PROTEIN KINASE |
| 690 | 1 | 0 | |a CENTRAL NERVOUS SYSTEM |
| 690 | 1 | 0 | |a CONFERENCE PAPER |
| 690 | 1 | 0 | |a COPING BEHAVIOR |
| 690 | 1 | 0 | |a CYTOKINE PRODUCTION |
| 690 | 1 | 0 | |a GENE OVEREXPRESSION |
| 690 | 1 | 0 | |a GENETIC ENGINEERING |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM |
| 690 | 1 | 0 | |a IMMUNE SYSTEM |
| 690 | 1 | 0 | |a IMMUNOCOMPETENT CELL |
| 690 | 1 | 0 | |a IMMUNOMODULATION |
| 690 | 1 | 0 | |a NEUROENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 700 | 1 | |a Vogl, A.M. | |
| 700 | 1 | |a Bonfiglio, J.J. | |
| 700 | 1 | |a Wurst, W. | |
| 700 | 1 | |a Holsboer, F. | |
| 700 | 1 | |a Arzt, E. | |
| 700 | 1 | |a Deussing, J.M. | |
| 700 | 1 | |a Refojo, D. | |
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