Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose
Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, binds specifically to poly-N-acetyllactosamine-enriched glycoconjugates. Through interactions with these glycoconjugates, this protein modulates inflammatory responses and contributes to tumor progression a...
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2009
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| LEADER | 15185caa a22017537a 4500 | ||
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| 001 | PAPER-8942 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203848.0 | ||
| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-60749084683 | |
| 024 | 7 | |2 cas |a galectin 1, 258495-34-0; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; tryptophan, 6912-86-3, 73-22-3; water, 7732-18-5; Galectin 1; Lactose, 63-42-3; LGALS1 protein, human; Solvents; Water, 7732-18-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BICHA | ||
| 100 | 1 | |a Di Lella, S. | |
| 245 | 1 | 0 | |a Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose |
| 260 | |c 2009 | ||
| 270 | 1 | 0 | |m Álvarez, R. M. S.; Instituto Superior de Investigaciones Biológicas (CONICET-UNT), Facultad de Bioqúimica, Química y Farmacia, Universidad Nacional de Tucumán, S. M. de Tucumán, Tucuman, Argentina; email: mysuko@fbqf.unt.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, binds specifically to poly-N-acetyllactosamine-enriched glycoconjugates. Through interactions with these glycoconjugates, this protein modulates inflammatory responses and contributes to tumor progression and immune cell homeostasis. The carbohydrate recognition domain includes the single protein tryptophan (Trp68). UV resonance Raman spectroscopy and molecular dynamic simulation were used to examine the change in the environment of the Trp on ligand binding. The UV Raman spectra and the calculated water radial distribution functions show that, while no large structural changes in the protein follow lactose binding, substantial solvent reorganization occurs. These new insights into the microscopic role of water molecules in Gal-1 binding to its specific carbohydrate ligands provides a better understanding of the physicochemical properties of Gal-1 - saccharide interactions, which will be useful for the design of synthetic inhibitors for therapeutic purposes. © 2009 American Chemical Society. |l eng | |
| 593 | |a Instituto Superior de Investigaciones Biológicas (CONICET-UNT), Facultad de Bioqúimica, Química y Farmacia, Universidad Nacional de Tucumán, S. M. de Tucumán, Tucuman, Argentina | ||
| 593 | |a Instituto de Qúimica-F́isica, Facultad de Bioqúimica, Química y Farmacia, Universidad Nacional de Tucumán, S. M. de Tucumán, Tucuman, Argentina | ||
| 593 | |a Departamento de Química Inorgánica, Analítica y Química-Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Department of Chemistry, Chevron Science Center, University of Pittsburgh, Pittsburgh, PN 15260, United States | ||
| 593 | |a Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BINDING PROTEINS |
| 690 | 1 | 0 | |a CARBOHYDRATE LIGANDS |
| 690 | 1 | 0 | |a CARBOHYDRATE-RECOGNITION DOMAINS |
| 690 | 1 | 0 | |a DISACCHARIDE LACTOSE |
| 690 | 1 | 0 | |a GALECTIN-1 |
| 690 | 1 | 0 | |a GLYCOCONJUGATES |
| 690 | 1 | 0 | |a IMMUNE CELLS |
| 690 | 1 | 0 | |a INFLAMMATORY RESPONSE |
| 690 | 1 | 0 | |a LIGAND BINDINGS |
| 690 | 1 | 0 | |a MOLECULAR DYNAMIC SIMULATIONS |
| 690 | 1 | 0 | |a PHYSICO-CHEMICAL PROPERTIES |
| 690 | 1 | 0 | |a RADIAL DISTRIBUTION FUNCTIONS |
| 690 | 1 | 0 | |a ROLE OF WATERS |
| 690 | 1 | 0 | |a SOLVENT ENVIRONMENTS |
| 690 | 1 | 0 | |a SOLVENT REORGANIZATIONS |
| 690 | 1 | 0 | |a STRUCTURAL CHANGES |
| 690 | 1 | 0 | |a SYNTHETIC INHIBITORS |
| 690 | 1 | 0 | |a TUMOR PROGRESSIONS |
| 690 | 1 | 0 | |a UV-RAMAN SPECTRUM |
| 690 | 1 | 0 | |a UV-RESONANCE RAMAN SPECTROSCOPIES |
| 690 | 1 | 0 | |a AMINO ACIDS |
| 690 | 1 | 0 | |a BIOCHEMISTRY |
| 690 | 1 | 0 | |a LIGANDS |
| 690 | 1 | 0 | |a MOLECULAR DYNAMICS |
| 690 | 1 | 0 | |a ORGANIC COMPOUNDS |
| 690 | 1 | 0 | |a POLYSACCHARIDES |
| 690 | 1 | 0 | |a RAMAN SCATTERING |
| 690 | 1 | 0 | |a RAMAN SPECTROSCOPY |
| 690 | 1 | 0 | |a SUGARS |
| 690 | 1 | 0 | |a DISTRIBUTION FUNCTIONS |
| 690 | 1 | 0 | |a CARBOHYDRATE |
| 690 | 1 | 0 | |a DISACCHARIDE |
| 690 | 1 | 0 | |a GALECTIN 1 |
| 690 | 1 | 0 | |a GLYCAN |
| 690 | 1 | 0 | |a LACTOSE |
| 690 | 1 | 0 | |a SOLVENT |
| 690 | 1 | 0 | |a TRYPTOPHAN |
| 690 | 1 | 0 | |a LGALS1 PROTEIN, HUMAN |
| 690 | 1 | 0 | |a SOLVENT |
| 690 | 1 | 0 | |a WATER |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a GENETIC CONSERVATION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IMMUNOCOMPETENT CELL |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a LIGAND BINDING |
| 690 | 1 | 0 | |a MOLECULAR DYNAMICS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHYSICAL CHEMISTRY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN CARBOHYDRATE INTERACTION |
| 690 | 1 | 0 | |a PROTEIN FAMILY |
| 690 | 1 | 0 | |a RAMAN SPECTROMETRY |
| 690 | 1 | 0 | |a TUMOR GROWTH |
| 690 | 1 | 0 | |a CHEMICAL MODEL |
| 690 | 1 | 0 | |a CHEMISTRY |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a COMPUTER SIMULATION |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PROTEIN BINDING |
| 690 | 1 | 0 | |a THERMODYNAMICS |
| 690 | 1 | 0 | |a X RAY CRYSTALLOGRAPHY |
| 690 | 1 | 0 | |a COMPUTER SIMULATION |
| 690 | 1 | 0 | |a CRYSTALLOGRAPHY, X-RAY |
| 690 | 1 | 0 | |a GALECTIN 1 |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LACTOSE |
| 690 | 1 | 0 | |a MODELS, CHEMICAL |
| 690 | 1 | 0 | |a PROTEIN BINDING |
| 690 | 1 | 0 | |a SOLVENTS |
| 690 | 1 | 0 | |a SPECTRUM ANALYSIS, RAMAN |
| 690 | 1 | 0 | |a THERMODYNAMICS |
| 690 | 1 | 0 | |a WATER |
| 650 | 1 | 7 | |2 spines |a HOMEOSTASIS |
| 700 | 1 | |a Ma, L. | |
| 700 | 1 | |a Díaz Ricci, J.C. | |
| 700 | 1 | |a Rabinovich, G.A. | |
| 700 | 1 | |a Asher, S.A. | |
| 700 | 1 | |a Álvarez, R.M.S. | |
| 773 | 0 | |d 2009 |g v. 48 |h pp. 786-791 |k n. 4 |p Biochemistry |x 00062960 |w (AR-BaUEN)CENRE-755 |t Biochemistry | |
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