Nitroimidazole derivatives: Non-randomness sister chromatid exchanges in human peripheral blood lymphocytes

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Nitroimidazole derivatives exhibited genotoxic effect in different experimental conditions. This study focuses on an evaluation of possible genomic targets, at a chromosomal level, of two 5-nitroimidazoles (ornidazole and metronidazole) using the in vitro human peripheral blood culture as experiment...

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Autor principal: Carballo, M.A
Otros Autores: Martinez, R.A, Mudry, M.D
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2009
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flagyl, Hoffmann La Roche; tiberal, Hoffmann La Roche
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 cas  |a metronidazole, 39322-38-8, 443-48-1; ornidazole, 16773-42-5; Biological Markers; Metronidazole, 443-48-1; Mutagens; Nitroimidazoles; Ornidazole, 16773-42-5 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a JJATD 
100 1 |a Carballo, M.A. 
245 1 0 |a Nitroimidazole derivatives: Non-randomness sister chromatid exchanges in human peripheral blood lymphocytes 
260 |c 2009 
270 1 0 |m Carballo, M. A.; CIGETOX-Citogenética Humana y Genética Toxicológica, Departamento Bioquímica Clínica, Universidad de Buenos Aires, Junin 956 (1113), Ciudad Autónoma de Buenos Aires, Argentina; email: macarballo2003@yahoo.com.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Nitroimidazole derivatives exhibited genotoxic effect in different experimental conditions. This study focuses on an evaluation of possible genomic targets, at a chromosomal level, of two 5-nitroimidazoles (ornidazole and metronidazole) using the in vitro human peripheral blood culture as experimental system. We observed that both derivatives showed a decrease in mitotic index (MI) (P < 0.001), an increase in sister chromatid exchanges (SCE) frequency (P < 0.001) and no modifications in cellular proliferation kinetics (CPK). As a null hypothesis we considered the assumption that larger chromosomes should harbor more SCE, which was viewed using a novel sequential G-band (400 band resolution)/SCE technique. The analysis showed highly significant chi square values (P < 0.001), indicating that SCE frequency per chromosome is not proportional to chromosome length. SCE could be considered an instability indicator due to the high correlation between SCEs in certain chromosomal bands and the exposure to nitroimidazole derivatives. Copyright © 2008 John Wiley & Sons, Ltd.  |l eng 
593 |a CIGETOX-Citogenética Humana y Genética Toxicológica, Departamento Bioquímica Clfnica. INFIBIOC, Universi- Dad de Buenos Aires, Junin 956 (1113), Ciudad Autónoma de Buenos Aires, Argentina 
593 |a Dpto de Filosofia e Ciencias Humanas, Universidade Estadual de Santa Cruz, Brazil 
593 |a GIBE-Grupo de Investigación en Biología Evolutiva Depto Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina 
593 |a CIGETOX-Citogenética Humana y Genética Toxicológica, Departamento Bioquímica Clínica, Universidad de Buenos Aires, Junin 956 (1113), Ciudad Autónoma de Buenos Aires, Argentina 
690 1 0 |a BIOMARKERS 
690 1 0 |a CHROMOSOMAL DAMAGE 
690 1 0 |a GENOMIC INSTABILITY 
690 1 0 |a GENOTOXICITY 
690 1 0 |a NITROIMIDAZOLES 
690 1 0 |a BIOLOGICAL MARKER 
690 1 0 |a METRONIDAZOLE 
690 1 0 |a NITROIMIDAZOLE DERIVATIVE 
690 1 0 |a ORNIDAZOLE 
690 1 0 |a ADULT 
690 1 0 |a ARTICLE 
690 1 0 |a BLOOD CULTURE 
690 1 0 |a CELL PROLIFERATION 
690 1 0 |a CHROMOSOME 
690 1 0 |a CHROMOSOME BAND 
690 1 0 |a CHROMOSOME DAMAGE 
690 1 0 |a CHROMOSOME SIZE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a CYTOTOXICITY 
690 1 0 |a DRUG EXPOSURE 
690 1 0 |a FEMALE 
690 1 0 |a GENOME ANALYSIS 
690 1 0 |a GENOMIC INSTABILITY 
690 1 0 |a GENOTOXICITY 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a HUMAN EXPERIMENT 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a MALE 
690 1 0 |a MITOSIS INDEX 
690 1 0 |a NORMAL HUMAN 
690 1 0 |a PERIPHERAL LYMPHOCYTE 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a SISTER CHROMATID EXCHANGE 
690 1 0 |a BIOLOGICAL MARKERS 
690 1 0 |a CELL DIVISION 
690 1 0 |a CELLS, CULTURED 
690 1 0 |a CHROMOSOME BANDING 
690 1 0 |a DOSE-RESPONSE RELATIONSHIP, DRUG 
690 1 0 |a FEMALE 
690 1 0 |a HUMANS 
690 1 0 |a LEUKOCYTES, MONONUCLEAR 
690 1 0 |a MALE 
690 1 0 |a METRONIDAZOLE 
690 1 0 |a MITOTIC INDEX 
690 1 0 |a MUTAGENICITY TESTS 
690 1 0 |a MUTAGENS 
690 1 0 |a NITROIMIDAZOLES 
690 1 0 |a ORNIDAZOLE 
690 1 0 |a SISTER CHROMATID EXCHANGE 
690 1 0 |a YOUNG ADULT 
653 0 0 |a flagyl, Hoffmann La Roche; tiberal, Hoffmann La Roche 
700 1 |a Martinez, R.A. 
700 1 |a Mudry, M.D. 
773 0 |d 2009  |g v. 29  |h pp. 248-254  |k n. 3  |p J. Appl. Toxicol.  |x 0260437X  |t Journal of Applied Toxicology 
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856 4 0 |u https://doi.org/10.1002/jat.1403  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_0260437X_v29_n3_p248_Carballo  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0260437X_v29_n3_p248_Carballo  |y Registro en la Biblioteca Digital 
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