The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures
The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevul...
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| Otros Autores: | , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1987
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 10306caa a22012497a 4500 | ||
|---|---|---|---|
| 001 | PAPER-870 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203013.0 | ||
| 008 | 190411s1987 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0023264651 | |
| 024 | 7 | |2 cas |a griseofulvin, 126-07-8; heme, 14875-96-8; porphyrin, 24869-67-8; Griseofulvin, 126-07-8; Heme, 14875-96-8; Porphyrins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a TXCYA | ||
| 100 | 1 | |a Vasquez, E. | |
| 245 | 1 | 4 | |a The effect of griseofulvin on the heme pathway. Studies on tissue explant cultures |
| 260 | |c 1987 | ||
| 270 | 1 | 0 | |m Batlle, A. |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Barnes, Hurworth, Millard, Erythropoietic porphyrin hepatitis (1968) J. Clin. Pathol., 21, p. 157 | ||
| 504 | |a Hashimoto, Kanie, Nibukura, Okumura, Sakai, Kajita, Erythropoietic protoporphyria associated with abnormalities of blood cells: An autopsied case (1970) Rinsho-Ketsu-Eki, 11, p. 49 | ||
| 504 | |a Ibayashi, Motomatsu, Tomizaki, Sakamoto, Eujoji, Matsuzaka, Protoporphyria erythropoitic with hepatopathy (1975) Taisha, 12, p. 1147 | ||
| 504 | |a Pimpstone, Webber, Blekkenhorst, Eales, The hepatic lesion in erythropoietic protoporphyria: Preliminary studies (1976) Ann. Clin. Res., 8, p. 122 | ||
| 504 | |a Miura, Torinuki, Skin porphyrin and UV-A irradiation (1978) Tohoku J. Exp. Med., 125, p. 199 | ||
| 504 | |a Miura, Torinuki, Morihana, A high skin protoporphyrin level in erythropoietic protoporphyria (1980) Tohoku J. Exp. Med., 130, p. 97 | ||
| 504 | |a Magnus, Jarrett, Prankerd, Rimington, Erythropoietic protoporphyria: A new porphyria syndrome with solar urticaria due to protoporphyrinaemia (1961) Lancet, 2, p. 448 | ||
| 504 | |a Bonkowsky, Bloomer, Event, Mahoney, Heme synthase defiecience in human protoporphyria. Demonstration o fthe defect in liver and culture skin fibroblast (1975) J. Clin. Invest., 56, p. 1139 | ||
| 504 | |a Bloomer, Brenner, Mahoney, Study of factor causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with erythropoietic protoporphyria (1977) J. Clin. Invest., 60, p. 1354 | ||
| 504 | |a Bloomer, Characterization of deficient heme synthase activity in protoporphyria with cultured skin fibroblast (1980) J. Clin. Invest., 65, p. 321 | ||
| 504 | |a Rimington, Magnus, Ryan, Cripps, Porphyria and photosensitivity (1967) Q. J. Med., 36, p. 29 | ||
| 504 | |a Bodaness, Chan, Singlet oxygen as a mediator in the hematoporphyrin catalyzed photooxidation of NADPH to NADP+ in deuterium oxide (1977) J. Biol. Chem., 252, p. 8554 | ||
| 504 | |a Cannistraro, Van der Vorst, Jori, EPR studies on singlet oxygen production by porphyrins (1978) Photochemistry and Photobiology, 28, p. 257 | ||
| 504 | |a Reese, Rimington, Biliary and urinary excretion of porphyrins in the rat studied by intravital fluorescence microscopy (1964) Br. J. Exp. Pathol., 45, p. 30 | ||
| 504 | |a Sandberg, Romslo, Phototoxicity of protoporphyrin as related to its subcellular localization in mice livers after short-term feeding with griseofulvin (1981) Biochem. J., 198, p. 67 | ||
| 504 | |a Sandberg, Protoporphyrin induced photodamage to mitochondria and lysosomes from rat liver (1981) Clin. Chim. Acta, 111, p. 55 | ||
| 504 | |a Bickers, Keogh, Rifkind, Harber, Kappas, Studies in porphyria IV: Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients (1977) J. Invest. Dermatol., 68, p. 5 | ||
| 504 | |a Gschanit, Wolff, Konrad, Erythropoietic protoporphyria. Submicroscopic events during the acute photosensitivity flare (1975) Br. J. Dermatol., 92, p. 545 | ||
| 504 | |a De Matteis, Rimington, Disturbance of porphyrin metabolism caused by griseofulvin in mice (1963) Br. J. Dermatol., 75, p. 91 | ||
| 504 | |a Gschnait, Konrad, Honigsmann, Denk, Wolff, Mouse model for protoporphyria I. The liver and hepatic protoporphyrin crystals (1975) J. Invest. Dermatol., 65, p. 290 | ||
| 504 | |a Weston-Hurst, Paget, Protoporphyrin cirrhosis and hepatoma in the livers of mice give griseofulvin (1963) British Journal of Dermatology, 75, p. 105 | ||
| 504 | |a Konrad, Honigsmann, Gschnait, Wolff, Mouse Model for protoporphyria II. Cellular and subcellular events in the photosensitivity flare of the skin (1975) J. Invest. Dermatol., 65, p. 300 | ||
| 504 | |a De Matteis, Gibbs, Drug-induced conversion of liver haem into modified porphyrins. Evidence for two classes of products (1980) Biochem. J., 187, p. 285 | ||
| 504 | |a De Matteis, Gibbs, Tephly, Inhibition of protohaem ferrolyase in experimental porphyria. Isolation and partial characterization of a modified porphyrin inhibitor (1980) Biochem. J., 188, p. 145 | ||
| 504 | |a De Matteis, Gibbs, Smith, Inhibition of protohaem ferrolyase by N-substituted porphyrins: Structural requirements for the inhibitory effect (1980) Biochem. J., 189, p. 645 | ||
| 504 | |a De Matteis, Gibbs, Jackson, Weersingh, Conversion of liver haem into N-substituted porphyrins or green pigments (1980) FEBS Lett., 119, p. 109 | ||
| 504 | |a Kunze, de Montellano, N-methyl porphyrin IX. Identification by NMR of the nitrogen alkylated in each of the four isomers (1981) J. Am. Chem. Soc., 103, p. 4225 | ||
| 504 | |a Tephly, Coffman, Ingall, Abou Zeit-Har, Tabba, Smith, Identification of N-methylprotoporphyrin IX in livers of untreated mice and mice treated with 3,5-diethoxycarbonyl-1,4-dihydrocollidine: Source of the methyl group (1981) Arch. Biochem. Biophys., 212, p. 120 | ||
| 504 | |a Vazquez, Navone, Polo, Afonso, Buzaleh, del C. Batlle, Biosíntesis de porfirinas en cultivos de explantes tisulares. Condiciones óptimas (1987) Rev. Argent. Dermatol., 68 (2), p. 121 | ||
| 504 | |a Fell, Robison, The growth development and phosphatase activity of embryonic avian femora and limb-buds cultivated “in vitro” (1929) Biochem J, 23, p. 767 | ||
| 504 | |a Mauzerall, Granick, The occurrence and determination of δ-aminolevulinic acid and porphobilinogen in urine (1956) J. Biol. Chem., 286, p. 1277 | ||
| 504 | |a With, Clinical use of porphyrin ester chromatography in urine and faeces (1975) Dan. Med. Bull., 22, p. 74 | ||
| 504 | |a Afonso, Chinarro Familiar, Stella, del C. Batlle, Lenczner, Magnin, Uroporfirinógeno decarboxilasa eritrocitaria y hepática en porfiria cutánea tardía (1985) Rev. Argent. Dermatol., 66, p. 12 | ||
| 504 | |a De Matteis, Gibbs, Stimulation of the pathway of porphyrin synthesis in the liver of rats and mice by griseofulvin, 3,5-diethoxycarbonyl-1,4-dihydrocollidine and related drugs: Evidence for 2 basically different mechanisms (1975) Biochem. J., 146, p. 285 | ||
| 520 | 3 | |a The effect of griseofulvin on porphyrin biosynthesis was studied in vitro and in vivo using liver and skin explants from mice. Neither porphyrin nor precursors accumulation was detected after in vitro treatment of explants with griseofulvin. Culture medium porphyrins formed from added σ-amino-laevulinic acid (ALA) were increased after oral chronic intoxication. Similar results were obtained by cutaneous and oral intoxication. Consequently griseofulvin topical application is proposed as an alternative method to produce experimental erythropoietic protoporphyria. Probable intoxication mechanism are proposed to explain the porphyrinogenic action of griseofulvin. © 1987. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: National Research Council | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Grants from the National Research Council (CONICET), the SUBCYT, University of Buenos Aires, Secretaria de Salud Pfiblica and Banco de la Naci6n Argentina are acknowledged. Alcira M. del C. Batlle holds the post of Principle Scientific Researcher at the CONICET. Elba Vfizquez, Susana Afonso, Ana Marfa Buzaleh, Nora Navone, C6sar Polo and Ernesto Schoua are Research Fellows at the CONICET. The valuable help of Rodolfo Bie-kofsky, Laura Dada and Jorge Muschietti in some experiments is greatly appreciated. | ||
| 593 | |a Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) - (UBA) and CONICET, Ciudad Universitaria, Pabellón II, 2do. Piso, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a GRISEOFULVIN |
| 690 | 1 | 0 | |a HAEM |
| 690 | 1 | 0 | |a N-METHYLPORPHYRINS |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a TISSUE CULTURE |
| 690 | 1 | 0 | |a GRISEOFULVIN |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a BLOOD AND HEMOPOIETIC SYSTEM |
| 690 | 1 | 0 | |a CONGENITAL ERYTHROPOIETIC PORPHYRIA |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a DRUG OVERDOSE |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a INTOXICATION |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a N METHYLPORPHYRIN DERIVATIVE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a ORAL DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a SKIN |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a TISSUE CULTURE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a GRISEOFULVIN |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a SKIN |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TISSUE CULTURE |
| 653 | 0 | 0 | |a grisovin, glaxo |
| 700 | 1 | |a Afonso, S. | |
| 700 | 1 | |a Buzaleh, A.M. | |
| 700 | 1 | |a Navone, N. | |
| 700 | 1 | |a Polo, C. | |
| 700 | 1 | |a Schoua, E. | |
| 700 | 1 | |a Batlle, A. | |
| 773 | 0 | |d 1987 |g v. 46 |h pp. 73-82 |k n. 1 |p Toxicology |x 0300483X |w (AR-BaUEN)CENRE-7043 |t Toxicology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0300-483X(87)90139-9 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0300483X_v46_n1_p73_Vasquez |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v46_n1_p73_Vasquez |y Registro en la Biblioteca Digital |
| 961 | |a paper_0300483X_v46_n1_p73_Vasquez |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 61823 | ||