Characterization of Junín virus particles inactivated by a zinc finger-reactive compound
Our previous studies reported the inhibitory action against arenaviruses of antiretroviral zinc finger-reactive compounds provided by the National Cancer Institute (USA). These compounds were able to inactivate virions as well as to reduce virus yields from infected cells. Here, the inactivation of...
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2009
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| 003 | AR-BaUEN | ||
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| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-67349181010 | |
| 024 | 7 | |2 cas |a disulfide, 16734-12-6; 1,1-azobisformamide, 123-77-3; Anti-HIV Agents; Azo Compounds; Carrier Proteins; Disulfides; Green Fluorescent Proteins, 147336-22-9; Nucleocapsid Proteins; Recombinant Fusion Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a VIRED | ||
| 100 | 1 | |a García, C.C. | |
| 245 | 1 | 0 | |a Characterization of Junín virus particles inactivated by a zinc finger-reactive compound |
| 260 | |c 2009 | ||
| 270 | 1 | 0 | |m Damonte, E.B.; Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina; email: edamonte@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Damonte, E.B., Junín virus (2002) Encyclopedia of Molecular Medicine, pp. 1844-1846. , Creighton T.E. (Ed), John Wiley & Sons Inc., New York | ||
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| 504 | |a López, N., Scolaro, L., Rossi, C., Jácamo, R., Candurra, N., Pujol, C., Damonte, E.B., Franze-Fernández, M.T., Homologous and heterologous glycoproteins induce protection against Junín virus challenge in guinea pigs (2000) J. Gen. Virol., 81, pp. 1273-1281 | ||
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| 504 | |a Rice, W.G., Turpin, J.A., Huang, M., Clanton, D., Buckheit Jr., R.W., Covell, D.G., Wallquist, A., Sausville, E.A., Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein (1997) Nat. Med., 3, pp. 341-345 | ||
| 504 | |a Rotz, L.D., Khan, A.S., Lillibridge, S.R., Ostroff, S.M., Hughes, J.M., Public health assessment of potential biological terrorism agents (2002) Emerg. Infect. Dis., 8, pp. 225-230 | ||
| 504 | |a Salvato, M.S., Schweighofer, K.J., Burns, J., Shimomaye, E.M., Biochemical and immunological evidence that the 11-kDa zinc-binding protein of lymphocytic choriomeningitis virus is a structural component of the virus (1992) Virus Res., 22, pp. 185-198 | ||
| 504 | |a Salvato, M.S., Molecular biology of the prototype arenavirus, lymphocytic choriomeningitis virus (1993) The Arenaviridae, pp. 133-156. , Salvato M.S. (Ed), Plenum Press, New York | ||
| 504 | |a Singh, I., Helenius, A., Role of ribosomes in Semliki Forest virus nucleocapsid uncoating (1992) J. Virol., 66, pp. 7049-7058 | ||
| 504 | |a Strecker, T., Eichler, R., ter Meulen, J., Weissenhorn, W., Klenk, H.D., Garten, W., Lenz, O., Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles (2003) J. Virol., 77, pp. 10700-10705 | ||
| 504 | |a Strecker, T., Maisa, A., Daffis, S., Eichler, R., Lenz, O., Garten, W., The role of myristoylation in the membrane association of the Lassa virus matrix protein Z (2006) Virol. J., 3, p. 93 | ||
| 504 | |a Tesh, R.B., Jahrling, P.B., Salas, R., Shope, R.E., Description of Guanarito virus (Arenaviridae: Arenavirus), the etiologic agent of Venezuelan hemorrhagic fever (1994) Am. J. Trop. Med. Hyg., 50, pp. 452-459 | ||
| 504 | |a Urata, S., Noda, T., Kawaoka, Y., Yokosawa, H., Yasuda, J., Cellular factors required for Lassa virus budding (2006) J. Virol., 80, pp. 4191-4195 | ||
| 504 | |a York, J., Nunberg, J.H., A novel zinc-binding domain is essential for formation of the functional Junín virus envelope glycoprotein complex (2007) J. Virol., 81, pp. 13385-13391 | ||
| 520 | 3 | |a Our previous studies reported the inhibitory action against arenaviruses of antiretroviral zinc finger-reactive compounds provided by the National Cancer Institute (USA). These compounds were able to inactivate virions as well as to reduce virus yields from infected cells. Here, the inactivation of the arenavirus Junín (JUNV), agent of Argentine hemorrhagic fever, by the aromatic disulfide NSC20625 was analyzed. The treatment of purified JUNV with this compound eliminated infectivity apparently through irreversible modifications in the matrix Z protein detected by: (a) alterations in the electrophoretic migration profile of Z under non-reducing conditions; (b) an electrodense labeling in the internal layer beneath the envelope and around the matrix Z protein, in negatively stained preparations; (c) changes in the subcellular localization of Z in cells transfected with a recombinant fusion protein JUNVZ-eGFP. The infection of Vero cells with JUNV inactivated particles was blocked at the uncoating of viral nucleocapsid from endosomes, providing new evidence for a functional role of Z in this stage of arenavirus cycle. Furthermore, the inactivated JUNV particles retained the immunoreactivity of the surface glycoprotein GP1 suggesting that this disulfide may be useful in the pursuit of an inactivating agent to obtain a vaccine antigen or diagnostic tool. © 2009 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: The authors acknowledge the National Cancer Institute, Frederick, USA, for providing the zinc finger-reactive compounds. This work was supported by grants from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Agencia Nacional de Promoción Científica y Tecnológica and Universidad de Buenos Aires, Argentina. CCG, LAS and EBD are members of the Research Career from CONICET. | ||
| 593 | |a Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ARENAVIRUS |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a MATRIX PROTEIN |
| 690 | 1 | 0 | |a VIRUS INACTIVATION |
| 690 | 1 | 0 | |a ZINC FINGER |
| 690 | 1 | 0 | |a DISULFIDE |
| 690 | 1 | 0 | |a DISULFIDE NSC20625 |
| 690 | 1 | 0 | |a ENHANCED GREEN FLUORESCENT PROTEIN |
| 690 | 1 | 0 | |a FATTY ACID BINDING PROTEIN |
| 690 | 1 | 0 | |a HYBRID PROTEIN |
| 690 | 1 | 0 | |a MATRIX PROTEIN |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELLULAR DISTRIBUTION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ELECTROPHORESIS |
| 690 | 1 | 0 | |a ENDOSOME |
| 690 | 1 | 0 | |a GENETIC TRANSFECTION |
| 690 | 1 | 0 | |a HEMORRHAGIC FEVER |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a VIROGENESIS |
| 690 | 1 | 0 | |a VIRUS INACTIVATION |
| 690 | 1 | 0 | |a VIRUS INFECTIVITY |
| 690 | 1 | 0 | |a VIRUS NUCLEOCAPSID |
| 690 | 1 | 0 | |a VIRUS PARTICLE |
| 690 | 1 | 0 | |a ZINC FINGER MOTIF |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTI-HIV AGENTS |
| 690 | 1 | 0 | |a ARENAVIRIDAE INFECTIONS |
| 690 | 1 | 0 | |a AZO COMPOUNDS |
| 690 | 1 | 0 | |a CARRIER PROTEINS |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a DISULFIDES |
| 690 | 1 | 0 | |a GREEN FLUORESCENT PROTEINS |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a MICROSCOPY, ELECTRON, TRANSMISSION |
| 690 | 1 | 0 | |a NUCLEOCAPSID PROTEINS |
| 690 | 1 | 0 | |a RECOMBINANT FUSION PROTEINS |
| 690 | 1 | 0 | |a VERO CELLS |
| 690 | 1 | 0 | |a VIRION |
| 690 | 1 | 0 | |a VIRUS INACTIVATION |
| 690 | 1 | 0 | |a ZINC FINGERS |
| 690 | 1 | 0 | |a ARENAVIRUS |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 700 | 1 | |a Ellenberg, P.C. | |
| 700 | 1 | |a Artuso, M.C. | |
| 700 | 1 | |a Scolaro, L.A. | |
| 700 | 1 | |a Damonte, E.B. | |
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