Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments
The immune system has evolved sophisticated mechanisms composed of several checkpoints and fail-safe processes that enable it to orchestrate innate and adaptive immunity, while at the same time limiting aberrant or unfaithful T-cell function. These multiple regulatory pathways take place during the...
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2009
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| LEADER | 46930caa a22030137a 4500 | ||
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| 001 | PAPER-8674 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131853.0 | ||
| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-67649794885 | |
| 024 | 7 | |2 cas |a galectin 1, 258495-34-0; Cytokines; Galectin 1; Polysaccharides | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IMRED | ||
| 100 | 1 | |a Rabinovich, G.A. | |
| 245 | 1 | 0 | |a Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments |
| 260 | |c 2009 | ||
| 270 | 1 | 0 | |m Rabinovich, G. A.; Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, C1428 Ciudad de Buenos Aires, Argentina; email: gabyrabi@ciudad.com.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Maynard, C.L., Weaver, C.T., Diversity in the contribution of interleukin-10 to T-cell mediated immune regulation (2008) Immunol Rev, 226, pp. 219-233 | ||
| 504 | |a Fife, B.T., Bluestone, J.A., Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways (2008) Immunol Rev, 224, pp. 166-182 | ||
| 504 | |a Peggs, K.S., Quezada, S.A., Allison, J.P., Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy (2008) Immunol Rev, 224, pp. 141-165 | ||
| 504 | |a Yang, R.Y., Rabinovich, G.A., Liu, F.T., Galectins: Structure, function and therapeutic potential (2008) Expert Rev Mol Med, 10, p. 17 | ||
| 504 | |a Rabinovich, G.A., Liu, F.-T., Hirashima, M., Anderson, A., An emerging role for galectins in tuning the immune response: Lessons from experimental models of inflammatory disease, autoimmunity and cancer (2007) Scandinavian Journal of Immunology, 66 (2-3), pp. 143-158. , DOI 10.1111/j.1365-3083.2007.01986.x | ||
| 504 | |a Cooper, D.N.W., Galectinomics: Finding themes in complexity (2002) Biochimica et Biophysica Acta - General Subjects, 1572 (2-3), pp. 209-231. , DOI 10.1016/S0304-4165(02)00310-0, PII S0304416502003100 | ||
| 504 | |a Rabinovich, G.A., Toscano, M.A., Jackson, S.S., Vasta, G.R., Functions of cell surface galectin-glycoprotein lattices (2007) Current Opinion in Structural Biology, 17 (5), pp. 513-520. , DOI 10.1016/j.sbi.2007.09.002, PII S0959440X07001303, Carbohydrates and glycoconjugates / Biophysical methods | ||
| 504 | |a Brewer, C.F., Miceli, M.C., Baum, L.G., Clusters, bundles, arrays and lattices: Novel mechanisms for lectin-saccharide-mediated cellular interactions (2002) Current Opinion in Structural Biology, 12 (5), pp. 616-623. , DOI 10.1016/S0959-440X(02)00364-0 | ||
| 504 | |a Song, X., Xia, B., Stowell, S.R., Lasanajak, Y., Smith, D.F., Cummings, R.D., Novel fluorescent glycan microarray strategy reveals ligands for galectins (2009) Chem Biol, 16, pp. 36-47 | ||
| 504 | |a Stowell, S.R., Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation (2009) J Biol Chem, 284, pp. 4989-4999 | ||
| 504 | |a Hirabayashi, J., Hashidate, T., Arata, Y., Nishi, N., Nakamura, T., Hirashima, M., Urashima, T., Kasai, K.-I., Oligosaccharide specificity of galectins: A search by frontal affinity chromatography (2002) Biochimica et Biophysica Acta - General Subjects, 1572 (2-3), pp. 232-254. , DOI 10.1016/S0304-4165(02)00311-2, PII S0304416502003112 | ||
| 504 | |a Stowell, S.R., Galectins-1, -2 and -3 exhibit differential recognition of sialylated glycans and blood group antigens (2008) J Biol Chem, 283, pp. 10109-10123 | ||
| 504 | |a Leffler, H., Carlsson, S., Hedlund, M., Qian, Y., Poirier, F., Introduction to galectins (2002) Glycoconjugate Journal, 19 (7-9), pp. 433-440. , DOI 10.1023/B:GLYC.0000014072.34840.04 | ||
| 504 | |a Seelenmeyer, C., Wegehingel, S., Tews, I., Kunzler, M., Aebi, M., Nickel, W., Cell surface counter receptors are essential components of the unconventional export machinery of galectin-1 (2005) Journal of Cell Biology, 171 (2), pp. 373-381. , http://www.jcb.org/cgi/reprint/171/2/373, DOI 10.1083/jcb.200506026 | ||
| 504 | |a Nickel, W., Unconventional secretory routes: Direct protein export across the plasma membrane of mammalian cells (2005) Traffic, 6 (8), pp. 607-614. , DOI 10.1111/j.1600-0854.2005.00302.x | ||
| 504 | |a Kasai, K., Galectin: Intelligent glue, non-bureaucratic bureaucrat or almighty supporting actor (1997) Trends Glycosci Glycotechnol, 9, pp. 167-170 | ||
| 504 | |a Vasta, G.R., Ahmed, H., Odom, E.W., Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates (2004) Current Opinion in Structural Biology, 14 (5), pp. 617-630. , DOI 10.1016/j.sbi.2004.09.008, PII S0959440X04001484 | ||
| 504 | |a Marth, J.D., Grewal, P.K., Mammalian glycosylation in immunity (2008) Nat Rev Immunol, 8, pp. 874-887 | ||
| 504 | |a Van Kooyk, Y., Rabinovich, G.A., Protein-glycan interactions in the control of innate and adaptive immune responses (2008) Nature Immunology, 9 (6), pp. 593-601. , DOI 10.1038/ni.f.203, PII NI.F.203 | ||
| 504 | |a Crocker, P.R., Paulson, J.C., Varki, A., Siglecs and their roles in the immune system (2007) Nature Reviews Immunology, 7 (4), pp. 255-266. , DOI 10.1038/nri2056, PII NRI2056 | ||
| 504 | |a Toscano, M.A., Ilarregui, J.M., Bianco, G.A., Campagna, L., Croci, D.O., Salatino, M., Rabinovich, G.A., Dissecting the pathophysiologic role of endogenous lectins: Glycan-binding proteins with cytokine-like activity? (2007) Cytokine and Growth Factor Reviews, 18 (1-2), pp. 57-71. , DOI 10.1016/j.cytogfr.2007.01.006, PII S135961010700007X | ||
| 504 | |a Elola, M.T., Wolfenstein-Todel, C., Troncoso, M.F., Vasta, G.R., Rabinovich, G.A., Galectins: Matricellular glycan-binding proteins linking cell adhesion, migration, and survival (2007) Cellular and Molecular Life Sciences, 64 (13), pp. 1679-1700. , DOI 10.1007/s00018-007-7044-8 | ||
| 504 | |a Garner, O.B., Baum, L.G., Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling (2008) Biochem Soc Trans, 36, pp. 1472-1477 | ||
| 504 | |a Rabinovich, G.A., Baum, L.G., Tinari, N., Paganelli, R., Natoli, C., Liu, F.-T., Iacobelli, S., Galectins and their ligands: Amplifiers, silencers or tuners of the inflammatory response? (2002) Trends in Immunology, 23 (6), pp. 313-320. , DOI 10.1016/S1471-4906(02)02232-9, PII S1471490602022329 | ||
| 504 | |a Levi, G., Teichberg, V.I., Isolation and physicochemical characterization of electrolectin, a β-D-galactoside binding lectin from the electric organ of Electrophorus electricus (1981) J Biol Chem, 256, pp. 5735-5740 | ||
| 504 | |a Blaser, C., Kaufmann, M., Muller, C., Zimmermann, C., Wells, V., Mallucci, L., Pircher, H., β-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells (1998) European Journal of Immunology, 28 (8), pp. 2311-2319. , DOI 10.1002/(SICI)1521-4141(199808)28:08<2311::AID-IMMU2311>3.0. CO;2-G | ||
| 504 | |a Fuertes, M.B., Molinero, L.L., Toscano, M.A., Ilarregui, J.M., Rubinstein, N., Fainboim, L., Zwirner, N.W., Rabinovich, G.A., Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70 S6 kinase (2004) Molecular and Cellular Biochemistry, 267 (1-2), pp. 177-185. , DOI 10.1023/B:MCBI.0000049376.50242.7f | ||
| 504 | |a Rabinovich, G.A., Ramhorst, R.E., Rubinstein, N., Corigliano, A., Daroqui, M.C., Kier-Joffe, E.B., Fainboim, L., Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms (2002) Cell Death and Differentiation, 9 (6), pp. 661-670. , DOI 10.1038/sj/cdd/4401009 | ||
| 504 | |a Zuniga, E., Rabinovich, G.A., Iglesias, M.M., Gruppi, A., Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis (2001) Journal of Leukocyte Biology, 70 (1), pp. 73-79 | ||
| 504 | |a Rabinovich, G., Castagna, L., Landa, C., Riera, C.M., Sotomayor, C., Regulated expression of a 16-kd galectin-like protein in activated rat macrophages (1996) Journal of Leukocyte Biology, 59 (3), pp. 363-370 | ||
| 504 | |a Rabinovich, G.A., Iglesias, M.M., Modesti, N.M., Castagna, L.F., Wolfenstein-Todel, C., Riera, C.M., Sotomayor, C.E., Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: Biochemical and functional characterization (1998) Journal of Immunology, 160 (10), pp. 4831-4840 | ||
| 504 | |a Sugimoto, N., Oida, T., Hirota, K., Nakamura, K., Nomura, T., Uchiyama, T., Sakaguchi, S., Foxp3-dependent and -independent molecules specific for CD25+ CD4+ natural regulatory T cells revealed by DNA microarray analysis (2006) International Immunology, 18 (8), pp. 1197-1209. , DOI 10.1093/intimm/dxl060 | ||
| 504 | |a Garin, M.I., Chu, N.-C., Golshayan, D., Cernuda-Morollon, E., Wait, R., Lechler, R.I., Galectin-1: A key effector of regulation mediated by CD4 +CD25+ T cells (2007) Blood, 109 (5), pp. 2058-2065. , http://bloodjournal.hematologylibrary.org/cgi/reprint/109/5/2058, DOI 10.1182/blood-2006-04-016451 | ||
| 504 | |a Kopcow, H.D., Rosetti, F., Leung, Y., Allan, D.S., Kutok, J.L., Strominger, J.L., T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1 (2008) Proc Natl Acad Sci USA, 105, pp. 18472-18477 | ||
| 504 | |a Maquoi, E., Van Den Brule, F.A., Castronovo, V., Foidart, J.-M., Changes in the distribution pattern of galectin-1 and galectin-3 in human placenta correlates with the differentiation pathways of trophoblasts (1997) Placenta, 18 (5-6), pp. 433-439. , DOI 10.1016/S0143-4004(97)80044-6 | ||
| 504 | |a Iglesias, M.M., Rabinovich, G.A., Ivanovic, V., Sotomayor, C., Wolfenstein-Todel, C., Galectin-1 from ovine placenta - Amino-acid sequence, physicochemical properties and implications in T-cell death (1998) European Journal of Biochemistry, 252 (3), pp. 400-407. , DOI 10.1046/j.1432-1327.1998.2520400.x | ||
| 504 | |a Blois, S.M., Ilarregui, J.M., Tometten, M., Garcia, M., Orsal, A.S., Cordo-Russo, R., Toscano, M.A., Arck, P.C., A pivotal role for galectin-1 in fetomaternal tolerance (2007) Nature Medicine, 13 (12), pp. 1450-1457. , DOI 10.1038/nm1680, PII NM1680 | ||
| 504 | |a Wollina, U., Sertoli cell expression of galectin-1 and -3 and accessible binding sites in normal human testis and Sertoli cell only-syndrome (1999) Histology and Histopathology, 14 (3), pp. 779-784 | ||
| 504 | |a Dettin, L., Rubinstein, N., Aoki, A., Rabinovich, G.A., Maldonado, C.A., Regulated expression and ultrastructural localization of galectin-1, a proapoptotic β-galactoside-binding lectin, during spermatogenesis in rat testis (2003) Biology of Reproduction, 68 (1), pp. 51-59. , DOI 10.1095/biolreprod.102.006361 | ||
| 504 | |a Ishida, K., Panjwani, N., Cao, Z., Streilein, J.W., Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms (2003) Ocular Immunology and Inflammation, 11 (2), pp. 91-105. , DOI 10.1076/ocii.11.2.91.15914 | ||
| 504 | |a Romero, M.D., Muino, J.C., Bianco, G.A., Ferrero, M., Juarez, C.P., Luna, J.D., Rabinovich, G.A., Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis (2006) Investigative Ophthalmology and Visual Science, 47 (4), pp. 1550-1556. , DOI 10.1167/iovs.05-1234 | ||
| 504 | |a Liu, F.-T., Rabinovich, G.A., Galectins as modulators of tumour progression (2005) Nature Reviews Cancer, 5 (1), pp. 29-41. , DOI 10.1038/nrc1527 | ||
| 504 | |a Rabinovich, G.A., Galectin-1 as a potential cancer target (2005) British Journal of Cancer, 92 (7), pp. 1188-1192. , DOI 10.1038/sj.bjc.6602493 | ||
| 504 | |a Zuniga, E., Gruppi, A., Hirabayashi, J., Kasai, K.I., Rabinovich, G.A., Regulated expression and effect of galectin-1 on Trypanosoma cruzi-infected macrophages: Modulation of microbicidal activity and survival (2001) Infection and Immunity, 69 (11), pp. 6804-6812. , DOI 10.1128/IAI.69.11.6804-6812.2001 | ||
| 504 | |a Rabinovich, G.A., Gruppi, A., Galectins as immunoregulators during infectious processes: From microbial invasion to the resolution of the disease (2005) Parasite Immunology, 27 (4), pp. 103-114. , DOI 10.1111/j.1365-3024.2005.00749.x | ||
| 504 | |a Ilarregui, J.M., Bianco, G.A., Toscano, M.A., Rabinovich, G.A., The coming of age of galectins as immunomodulatory agents: Impact of these carbohydrate binding proteins in T cell physiology and chronic inflammatory disorders (2005) Ann Rheum Dis, 4, pp. 96-103 | ||
| 504 | |a Harjacek, M., Diaz-Cano, S., De Miguel, M., Wolfe, H., Maldonado, C.A., Rabinovich, G.A., Expression of galectins-1 and -3 correlates with defective mononuclear cell apoptosis in patients with juvenile idiopathic arthritis (2001) Journal of Rheumatology, 28 (8), pp. 1914-1922 | ||
| 504 | |a Camby, I., Le Mercier, M., Lefranc, F., Kiss, R., Galectin-1: A small protein with major functions (2006) Glycobiology, 16 (11), pp. 137R-157R. , DOI 10.1093/glycob/cwl025 | ||
| 504 | |a Salatino, M., Croci, D.O., Bianco, G.A., Ilarregui, J.M., Toscano, M.A., Rabinovich, G.A., Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer (2008) Expert Opinion on Biological Therapy, 8 (1), pp. 45-57. , DOI 10.1517/14712598.8.1.45 | ||
| 504 | |a Schwarz, F.P., Ahmed, H., Bianchet, M.A., Amzel, L.M., Vasta, G.R., Thermodynamics of bovine spleen galectin-1 binding to disaccharides: Correlation with structure and its effect on oligomerization at the denaturation temperature (1998) Biochemistry, 37 (17), pp. 5867-5877. , DOI 10.1021/bi9716478 | ||
| 504 | |a He, L., Andre, S., Siebert, H.-C., Helmholz, H., Niemeyer, B., Gabiust, H.-J., Detection of ligand- and solvent-induced shape alterations of cell-growth-regulatory human lectin galectin-1 in solution by small angle neutron and x-ray scattering (2003) Biophysical Journal, 85 (1), pp. 511-524 | ||
| 504 | |a Charvatova, O., Foley, B.L., Bern, M.W., Sharp, J.S., Orlando, R., Woods, R.J., Quantifying protein interface footprinting by hydroxyl radical oxidation and molecular dynamics simulation: Application to galectin-1 (2008) J Am Soc Mass Spectrom, 19, pp. 1692-1705 | ||
| 504 | |a Di Lella, S., Ma, L., Ricci, J.C., Rabinovich, G.A., Asher, S.A., Alvarez, R.M., Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose (2009) Biochemistry, 48, pp. 786-791 | ||
| 504 | |a Tateno, H., Glycoconjugate microarray based on an evanescent-field fluorescence-assisted detection principle for investigation of glycan-binding proteins (2008) Glycobiology, 18, pp. 789-798 | ||
| 504 | |a Rapoport, E.M., Galectin-loaded cells as a platform for the profiling of lectin specificity by fluorescent neoglycoconjugates: A case study on galectins-1 and -3 and the impact of assay setting (2008) Glycobiology, 18, pp. 315-324 | ||
| 504 | |a Saussez, S., Glinoer, D., Chantrain, G., Pattou, F., Carnaille, B., Andre, S., Gabius, H.-J., Laurent, G., Serum galectin-1 and galectin-3 levels in benign and malignant nodular thyroid disease (2008) Thyroid, 18 (7), pp. 705-712. , DOI 10.1089/thy.2007.0361 | ||
| 504 | |a Adams, L., Scott, G.K., Weinberg, C.S., Biphasic modulation of cell growth by recombinant human galectin-1 (1996) Biochimica et Biophysica Acta - Molecular Cell Research, 1312 (2), pp. 137-144. , DOI 10.1016/0167-4889(96)00031-6 | ||
| 504 | |a Levroney, E.L., Aguilar, H.C., Fulcher, J.A., Kohatsu, L., Pace, K.E., Pang, M., Gurney, K.B., Lee, B., Novel innate immune functions for galectin-1: Galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines (2005) Journal of Immunology, 175 (1), pp. 413-420 | ||
| 504 | |a Barrionuevo, P., Beigier-Bompadre, M., Ilarregui, J.M., Toscano, M.A., Bianco, G.A., Isturiz, M.A., Rabinovich, G.A., A novel function for galectin-1 at the crossroad of innate and adaptive immunity: Galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic EMK-dependent pathway (2007) Journal of Immunology, 178 (1), pp. 436-445 | ||
| 504 | |a Strasser, A., Bouillet, P., The control of apoptosis in lymphocyte selection (2003) Immunological Reviews, 193, pp. 82-92. , DOI 10.1034/j.1600-065X.2003.00036.x | ||
| 504 | |a Bidere, N., Su, H.C., Lenardo, M.J., Genetic disorders of programmed cell death in the immune system (2006) Annu Rev Immunol, 24, pp. 321-352 | ||
| 504 | |a Perillo, N.L., Pace, K.E., Seilhamer, J.J., Baum, L.G., Apoptosis of T cells mediated by galectin-1 (1995) Nature, 378, pp. 736-739 | ||
| 504 | |a Perillo, N.L., Uittenbogaart, C.H., Nguyen, J.T., Baum, L.G., Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes (1997) Journal of Experimental Medicine, 185 (10), pp. 1851-1858. , DOI 10.1084/jem.185.10.1851 | ||
| 504 | |a Pace, K.E., Lee, C., Stewart, P.L., Baum, L.G., Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1 (1999) Journal of Immunology, 163 (7), pp. 3801-3811 | ||
| 504 | |a Rabinovich, G.A., Alonso, C.R., Sotomayor, C.E., Durand, S., Bocco, J.L., Riera, C.M., Molecular mechanisms implicated in galectin-1-induced apoptosis: Activation of the AP-1 transcription factor and downregulation of Bcl-2 (2000) Cell Death and Differentiation, 7 (8), pp. 747-753 | ||
| 504 | |a Nguyen, J.T., Evans, D.P., Galvan, M., Pace, K.E., Leitenberg, D., Bui, T.N., Baum, L.G., CD45 modulates galectin-1-induced T cell death: Regulation by expression of core 2 O-glycans (2001) Journal of Immunology, 167 (10), pp. 5697-5707 | ||
| 504 | |a Battig, P., Saudan, P., Gunde, T., Bachmann, M.F., Enhanced apoptotic activity of a structurally optimized form of galectin-1 (2004) Molecular Immunology, 41 (1), pp. 9-18. , DOI 10.1016/j.molimm.2004.02.004, PII S0161589004000495 | ||
| 504 | |a He, J., Baum, L.G., Presentation of Galectin-1 by Extracellular Matrix Triggers T Cell Death (2004) Journal of Biological Chemistry, 279 (6), pp. 4705-4712. , DOI 10.1074/jbc.M311183200 | ||
| 504 | |a Hahn, H.P., Pang, M., He, J., Hernandez, J.D., Yang, R.-Y., Li, L.Y., Wang, X., Baum, L.G., Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death (2004) Cell Death and Differentiation, 11 (12), pp. 1277-1286. , DOI 10.1038/sj.cdd.4401485 | ||
| 504 | |a Matarrese, P., Tinari, A., Mormone, E., Bianco, G.A., Toscano, M.A., Ascione, B., Rabinovich, G.A., Malorni, W., Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission (2005) Journal of Biological Chemistry, 280 (8), pp. 6969-6985. , DOI 10.1074/jbc.M409752200 | ||
| 504 | |a Endharti, A.T., Zhou, Y.W., Nakashima, I., Suzuki, H., Galectin-1 supports survival of naive T cells without promoting cell proliferation (2005) European Journal of Immunology, 35 (1), pp. 86-97. , DOI 10.1002/eji.200425340 | ||
| 504 | |a Ion, G., Fajka-Boja, R., Kovacs, F., Szebeni, G., Gombos, I., Czibula, A., Matko, J., Monostori, E., Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1 (2006) Cellular Signalling, 18 (11), pp. 1887-1896. , DOI 10.1016/j.cellsig.2006.02.007, PII S0898656806000416 | ||
| 504 | |a Stillman, B.N., Hsu, D.K., Pang, M., Brewer, C.F., Johnson, P., Liu, F.-T., Baum, L.G., Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death (2006) Journal of Immunology, 176 (2), pp. 778-789 | ||
| 504 | |a Perone, M.J., Larregina, A.T., Shufesky, W.J., Papworth, G.D., Sullivan, M.L.G., Zahorchak, A.F., Stolz, D.B., Morelli, A.E., Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells (2006) Journal of Immunology, 176 (12), pp. 7207-7220 | ||
| 504 | |a Gonzalez, M.I., Rubinstein, N., Ilarregui, J.M., Toscano, M.A., Sanjuan, N.A., Rabinovich, G.A., Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: Implications for T cell apoptosis (2005) Int J Immunopathol Pharmacol, 18, pp. 615-623 | ||
| 504 | |a Toscano, M.A., Bianco, G.A., Ilarregui, J.M., Croci, D.O., Correale, J., Hernandez, J.D., Zwirner, N.W., Rabinovich, G.A., Differential glycosylation of TH1, TH2 and T H-17 effector cells selectively regulates susceptibility to cell death (2007) Nature Immunology, 8 (8), pp. 825-834. , DOI 10.1038/ni1482, PII NI1482 | ||
| 504 | |a Juszczynski, P., Ouyang, J., Monti, S., Rodig, S.J., Takeyama, K., Abramson, J., Chen, W., Shipp, M.A., The AP1-dependent secretion of galectin-1 by Reed-Sternberg cells fosters immune privilege in classical Hodgkin lymphoma (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (32), pp. 13134-13139. , http://www.pnas.org/cgi/reprint/104/32/13134, DOI 10.1073/pnas.0706017104 | ||
| 504 | |a Brandt, B., Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes (2008) Histochem Cell Biol, 129, pp. 599-609 | ||
| 504 | |a Rabinovich, G.A., Modesti, N.M., Castagna, L.F., Landa, C.A., Riera, C.M., Sotomayor, C.E., Specific inhibition of lymphocyte proliferation and induction of apoptosis by CLL-I, a β-galactoside-binding lectin (1997) Journal of Biochemistry, 122 (2), pp. 365-373 | ||
| 504 | |a Walzel, H., Blach, M., Hirabayashi, J., Kasai, K.-I., Brock, J., Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells (2000) Glycobiology, 10 (2), pp. 131-140 | ||
| 504 | |a Pace, K.E., Hahn, H.P., Pang, M., Nguyen, J.T., Baum, L.G., Cutting edge: CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death (2000) Journal of Immunology, 165 (5), pp. 2331-2334 | ||
| 504 | |a Rappl, G., Abken, H., Muche, J.M., Sterry, W., Tilgen, W., Andre, S., Kaltner, H., Reinhold, U., CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death (2002) Leukemia, 16 (5), pp. 840-845. , DOI 10.1038/sj.leu.2402438 | ||
| 504 | |a Roberts, A.A., Amano, M., Felten, C., Galvan, M., Sulur, G., Pinter-Brown, L., Dobbeling, U., Baum, L.G., Galectin-1-mediated apoptosis in mycosis fungoides: The roles of CD7 and cell surface glycosylation (2003) Modern Pathology, 16 (6), pp. 543-551. , DOI 10.1097/01.MP.0000071840.84469.06 | ||
| 504 | |a Cabrera, P.V., Amano, M., Mitoma, J., Chan, J., Said, J., Fukuda, M., Baum, L.G., Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death (2006) Blood, 108 (7), pp. 2399-2406. , http://www.bloodjournal.org/cgi/reprint/108/7/2399, DOI 10.1182/blood-2006-04-018556 | ||
| 504 | |a Amano, M., Galvan, M., He, J., Baum, L.G., The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death (2003) Journal of Biological Chemistry, 278 (9), pp. 7469-7475. , DOI 10.1074/jbc.M209595200 | ||
| 504 | |a Hernandez, J.D., Nguyen, J.T., He, J., Wang, W., Ardman, B., Green, J.M., Fukuda, M., Baum, L.G., Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death (2006) Journal of Immunology, 177 (8), pp. 5328-5336 | ||
| 504 | |a Carlow, D.A., Williams, M.J., Ziltener, H.J., Modulation of O-Glycans and N-Glycans on Murine CD8 T Cells Fails to Alter Annexin V Ligand Induction by Galectin 1 (2003) Journal of Immunology, 171 (10), pp. 5100-5106 | ||
| 504 | |a Comelli, E.M., Sutton-Smith, M., Yan, Q., Amado, M., Panico, M., Gilmartin, T., Whisenant, T., Paulson, J.C., Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans (2006) Journal of Immunology, 177 (4), pp. 2431-2440 | ||
| 504 | |a Motran, C.C., Molinder, K.M., Liu, S.D., Poirier, F., Miceli, M.C., Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function (2008) Eur J Immunol, 38, pp. 3015-3027 | ||
| 504 | |a Tabrizi, S.J., T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins (2009) J Immunol, 182, pp. 1490-1499 | ||
| 504 | |a Ion, G., Fajka-Boja, R., Toth, G.K., Caron, M., Monostori, E., Role of p56lck and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death [2] (2005) Cell Death and Differentiation, 12 (8), pp. 1145-1147. , DOI 10.1038/sj.cdd.4401628 | ||
| 504 | |a Perone, M.J., Suppression of autoimmune diabetes by soluble galectin-1 (2009) J Immunol, 182, pp. 2641-2653 | ||
| 504 | |a Rubinstein, N., Alvarez, M., Zwirner, N.W., Toscano, M.A., Ilarregui, J.M., Bravo, A., Mordoh, J., Rabinovich, G.A., Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumor-immune privilege (2004) Cancer Cell, 5 (3), pp. 241-251. , DOI 10.1016/S1535-6108(04)00024-8, PII S1535610804000248 | ||
| 504 | |a Stowell, S.R., Karmakar, S., Stowell, C.J., Dias-Baruffi, M., McEver, R.P., Cummings, R.D., Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells (2007) Blood, 109 (1), pp. 219-227. , http://www.bloodjournal.org/cgi/reprint/109/1/219, DOI 10.1182/blood-2006-03-007153 | ||
| 504 | |a Stowell, S.R., Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion (2008) J Immunol, 180, pp. 3091-3102 | ||
| 504 | |a Castellani, P., Angelini, G., Delfino, L., Matucci, A., Rubartelli, A., The thiol redox state of lymphoid organs is modified by immunization: Role of different immune cell populations (2008) Eur J Immunol, 38, pp. 2419-2425 | ||
| 504 | |a Van Der Leij, J., Van Den Berg, A., Harms, G., Eschbach, H., Vos, H., Zwiers, P., Van Weeghel, R., Visser, L., Strongly enhanced IL-10 production using stable galectin-1 homodimers (2007) Molecular Immunology, 44 (4), pp. 506-513. , DOI 10.1016/j.molimm.2006.02.011, PII S016158900600037X | ||
| 504 | |a Nishi, N., Abe, A., Iwaki, J., Yoshida, H., Itoh, A., Shoji, H., Kamitori, S., Nakamura, T., Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1 (2008) Glycobiology, 18 (12), pp. 1065-1073. , DOI 10.1093/glycob/cwn089 | ||
| 504 | |a Liu, S.D., Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes (2008) Blood, 112, pp. 120-130 | ||
| 504 | |a Baum, L.G., Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells (1995) J Exp Med, 181, pp. 877-887 | ||
| 504 | |a Silva-Monteiro, E., Lorenzato, L.R., Nihei, O.K., Junqueira, M., Rabinovich, G.A., Hsu, D.K., Liu, F.-T., Villa-Verde, D.M.S., Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection (2007) American Journal of Pathology, 170 (2), pp. 546-556. , DOI 10.2353/ajpath.2007.060389 | ||
| 504 | |a Chung, C.D., Patel, V.P., Moran, M., Lewis, L.A., Miceli, M.C., Galectin-1 induces partial TCR ζ-chain phosphorylation and antagonizes processive TCR signal transduction (2000) Journal of Immunology, 165 (7), pp. 3722-3729 | ||
| 504 | |a Demetriou, M., Granovsky, M., Quaggin, S., Dennis, J.W., Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation (2001) Nature, 409 (6821), pp. 733-739. , DOI 10.1038/35055582 | ||
| 504 | |a Lee, S.U., N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration (2007) J Biol Chem, 282, pp. 33725-33734 | ||
| 504 | |a Chen, I.-J., Chen, H.-L., Demetriou, M., Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling (2007) Journal of Biological Chemistry, 282 (48), pp. 35361-35372. , http://www.jbc.org/cgi/reprint/282/48/35361, DOI 10.1074/jbc.M706923200 | ||
| 504 | |a Butcher, E.C., Picker, L.J., Lymphocyte homing and homeostasis (1996) Science, 272 (5258), pp. 60-66 | ||
| 504 | |a Kannagi, R., Regulatory roles of carbohydrate ligands for selectins in the homing of lymphocytes (2002) Current Opinion in Structural Biology, 12 (5), pp. 599-608. , DOI 10.1016/S0959-440X(02)00365-2 | ||
| 504 | |a Rabinovich, G.A., Ariel, A., Hershkoviz, R., Hirabayashi, J., Kasai, K.-I., Lider, O., Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1 (1999) Immunology, 97 (1), pp. 100-106. , DOI 10.1046/j.1365-2567.1999.00746.x | ||
| 504 | |a He, J., Baum, L.G., Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration (2006) Laboratory Investigation, 86 (6), pp. 578-590. , DOI 10.1038/labinvest.3700420, PII 3700420 | ||
| 504 | |a Norling, L.V., Sampaio, A.L.F., Cooper, D., Perretti, M., Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking (2008) FASEB Journal, 22 (3), pp. 682-690. , http://www.fasebj.org/cgi/reprint/22/3/682, DOI 10.1096/fj.07-9268com | ||
| 504 | |a Wan, Y.Y., Flavell, R.A., 'Yin-Yang' functions of transforming growth factor-β and T regulatory cells in immune regulation (2007) Immunological Reviews, 220 (1), pp. 199-213. , DOI 10.1111/j.1600-065X.2007.00565.x | ||
| 504 | |a Toscano, M.A., Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses (2006) J Immunol, 176, pp. 6323-6332 | ||
| 504 | |a Brusko, T.M., Putnam, A.L., Bluestone, J.A., Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities (2008) Immunological Reviews, 223 (1), pp. 371-390. , DOI 10.1111/j.1600-065X.2008.00637.x | ||
| 504 | |a Rabinovich, G.A., Gabrilovich, D., Sotomayor, E.M., Immunosuppressive strategies that are mediated by tumor cells (2007) Annual Review of Immunology, 25, pp. 267-296. , DOI 10.1146/annurev.immunol.25.022106.141609 | ||
| 504 | |a Trowsdale, J., Betz, A.G., Mother's little helpers: Mechanisms of maternal-fetal tolerance (2006) Nat Immunol, 7, pp. 241-246 | ||
| 504 | |a Terness, P., Kallikourdis, M., Betz, A.G., Rabinovich, G.A., Saito, S., Clark, D.A., Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells (2007) American Journal of Reproductive Immunology, 58 (3), pp. 238-254. , DOI 10.1111/j.1600-0897.2007.00510.x | ||
| 504 | |a Von Wolff, M., Wang, X., Gabius, H.-J., Strowitzki, T., Galectin fingerprinting in human endometrium and decidua during the menstrual cycle and in early gestation (2005) Molecular Human Reproduction, 11 (3), pp. 189-194. , DOI 10.1093/molehr/gah144 | ||
| 504 | |a Phillips, B., Knisley, K., Weitlauf, K.D., Dorsett, J., Lee, V., Weitlauf, H., Differential expression of two β-galactoside-binding lectins in the reproductive tracts of pregnant mice (1996) Biology of Reproduction, 55 (3), pp. 548-558 | ||
| 504 | |a Bozic, M., Petronijevic, M., Milenkovic, S., Atanackovic, J., Lazic, J., Vicovac, Lj., Galectin-1 and galectin-3 in the trophoblast of the gestational trophoblastic disease (2004) Placenta, 25 (10), pp. 797-802. , DOI 10.1016/j.placenta.2004.03.006, PII S0143400404000992 | ||
| 504 | |a Fulcher, J.A., Hashimi, S.T., Levroney, E.L., Pang, M., Gurney, K.B., Baum, L.G., Lee, B., Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix (2006) Journal of Immunology, 177 (1), pp. 216-226 | ||
| 504 | |a Than, N.G., Emergence of hormonal and redox regulation of galectin-1 in placental mammals: Implication in maternal-fetal immune tolerance (2008) Proc Natl Acad Sci USA, 105, pp. 15819-15824 | ||
| 504 | |a Purcell, A.W., Van Driel, I.R., Gleeson, P.A., Impact of glycans on T-cell tolerance to glycosylated self-antigens (2008) Immunol Cell Biol, 86, pp. 574-579 | ||
| 504 | |a Levi, G., Tarrab-Hazdai, R., Teichberg, V.I., Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits (1983) Eur J Immunol, 13, pp. 500-507 | ||
| 504 | |a Offner, H., Celnik, B., Bringman, T.S., Casentini-Borocz, D., Nedwin, G.E., Vandenbark, A.A., Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis (1990) Journal of Neuroimmunology, 28 (2), pp. 177-184. , DOI 10.1016/0165-5728(90)90032-I | ||
| 504 | |a Rabinovich, G.A., Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis (1999) J Exp Med, 190, pp. 385-398 | ||
| 504 | |a Santucci, L., Fiorucci, S., Cammilleri, F., Servillo, G., Federici, B., Morelli, A., Galectin-1 exerts immunomodulatory and protective effects on Concanavalin A-induced hepatitis in mice (2000) Hepatology, 31 (2), pp. 399-406 | ||
| 504 | |a Santucci, L., Fiorucci, S., Rubinstein, N., Mencarelli, A., Palazzetti, B., Federici, B., Rabinovich, G.A., Morelli, A., Galectin-1 suppresses experimental colitis in mice (2003) Gastroenterology, 124 (5), pp. 1381-1394. , DOI 10.1016/S0016-5085(03)00267-1 | ||
| 504 | |a Baum, L.G., Blackall, D.P., Arias-Magallano, S., Nanigian, D., Uh, S.Y., Browne, J.M., Hoffmann, D., Baldwin, G.C., Amelioration of graft versus host disease by galectin-1 (2003) Clinical Immunology, 109 (3), pp. 295-307. , DOI 10.1016/j.clim.2003.08.003 | ||
| 504 | |a Perone, M.J., Bertera, S., Tawadrous, Z.S., Shufesky, W.J., Piganelli, J.D., Baum, L.G., Trucco, M., Morelli, A.E., Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice (2006) Journal of Immunology, 177 (8), pp. 5278-5289 | ||
| 504 | |a Giordanengo, L., Gea, S., Barbieri, G., Rabinovich, G.A., Anti-galectin-1 autoantibodies in human Trypanosoma cruzi infection: Differential expression of this β-galactoside-binding protein in cardiac Chagas' disease (2001) Clinical and Experimental Immunology, 124 (2), pp. 266-273. , DOI 10.1046/j.1365-2249.2001.01512.x | ||
| 504 | |a Croci, D.O., Zacarias Fluck, M.F., Rico, M.J., Matar, P., Rabinovich, G.A., Scharovsky, O.G., Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment (2007) Cancer Immunology, Immunotherapy, 56 (11), pp. 1687-1700. , DOI 10.1007/s00262-007-0343-y | ||
| 504 | |a Thijssen, V.L., Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy (2006) Proc Natl Acad Sci USA, 103, pp. 15975-15980 | ||
| 504 | |a Gandhi, M.K., Moll, G., Smith, C., Dua, U., Lambley, E., Ramuz, O., Gill, D., Khanna, R., Galectin-1 mediated suppression of Epstein-Barr virus-specific T-cell immunity in classic Hodgkin lymphoma (2007) Blood, 110 (4), pp. 1326-1329. , http://bloodjournal.hematologylibrary.org/cgi/reprint/110/4/1326, DOI 10.1182/blood-2007-01-066100 | ||
| 504 | |a Rodig, S.J., AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features (2008) Clin Cancer Res, 14, pp. 3338-3344 | ||
| 504 | |a Valenzuela, H.F., Pace, K.E., Cabrera, P.V., White, R., Porvari, K., Kaija, H., Vihko, P., Baum, L.G., O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1 (2007) Cancer Research, 67 (13), pp. 6155-6162. , http://cancerres.aacrjournals.org/cgi/reprint/67/13/6155, DOI 10.1158/0008-5472.CAN-05-4431 | ||
| 504 | |a Le, Q.T., Galectin-1: A link between tumor hypoxia and tumor immune privilege (2005) J Clin Oncol, 23, pp. 8932-8941 | ||
| 504 | |a Daroqui, C.M., Ilarregui, J.M., Rubinstein, N., Salatino, M., Toscano, M.A., Vazquez, P., Bakin, A., Rabinovich, G.A., Regulation of galectin-1 expression by transforming growth factor β1 in metastatic mammary adenocarcinoma cells: Implications for tumor-immune escape (2007) Cancer Immunology, Immunotherapy, 56 (4), pp. 491-499. , DOI 10.1007/s00262-006-0208-9 | ||
| 504 | |a Zacarias Fluck, M.F., Rico, M.J., Gervasoni, S.I., Ilarregui, J.M., Toscano, M.A., Rabinovich, G.A., Scharovsky, O.G., Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat lymphoma model (2007) Cancer Immunology, Immunotherapy, 56 (2), pp. 237-248. , DOI 10.1007/s00262-006-0176-0 | ||
| 504 | |a Lu, Y., Lotan, D., Lotan, R., Differential regulation of constitutive and retinoic acid-induced galectin-1 gene transcription in murine embryonal carcinoma and myoblastic cells (2000) Biochimica et Biophysica Acta - Gene Structure and Expression, 1491 (1-3), pp. 13-19. , DOI 10.1016/S0167-4781(00)00055-5, PII S0167478100000555 | ||
| 504 | |a Serhan, C.N., Brain, S.D., Buckley, C.D., Gilroy, D.W., Haslett, C., O'Neill, L.A.J., Perretti, M., Wallace, J.L., Resolution of inflammation: State of the art, definitions and terms (2007) FASEB Journal, 21 (2), pp. 325-332. , http://www.fasebj.org/cgi/reprint/21/2/325, DOI 10.1096/fj.06-7227rev | ||
| 504 | |a Rabinovich, G.A., Sotomayor, C.E., Riera, C.M., Bianco, I., Correa, S.G., Evidence of a role for galectin-1 in acute inflammation (2000) European Journal of Immunology, 30 (5), pp. 1331-1339 | ||
| 504 | |a La, M., Cao, T.V., Cerchiaro, G., Chilton, K., Hirabayashi, J., Kasai, K.-I., Oliani, S.M., Perretti, M., A novel biological activity for galectin-1: Inhibition of leukocyte-endothelial cell interactions in experimental inflammation (2003) American Journal of Pathology, 163 (4), pp. 1505-1515 | ||
| 504 | |a Stowell, S.R., Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane (2009) Mol Biol Cell, 20, pp. 1408-1418 | ||
| 504 | |a Karmakar, S., Stowell, S.R., Cummings, R.D., McEver, R.P., Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans (2008) Glycobiology, 18, pp. 770-778 | ||
| 504 | |a Correa, S.G., Sotomayor, C.E., Aoki, M.P., Maldonado, C.A., Rabinovich, G.A., Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages (2003) Glycobiology, 13 (2), pp. 119-128. , DOI 10.1093/glycob/cwg010 | ||
| 504 | |a Pacienza, N., The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation (2008) FASEB J, 22, pp. 1113-1123 | ||
| 504 | |a Andre, S., Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates (2001) Chembiochem, 2, pp. 822-830 | ||
| 504 | |a Sorme, P., Kahl-Knutsson, B., Wellmar, U., Magnusson, B.-G., Leffler, H., Nilsson, U.J., Design and synthesis of galectin inhibitors (2003) Methods in Enzymology, 363, pp. 157-169. , DOI 10.1016/S0076-6879(03)01050-4 | ||
| 504 | |a Ingrassia, L., Camby, I., Lefranc, F., Mathieu, V., Nshimyumukiza, P., Darro, F., Kiss, R., Anti-galectin compounds as potential anti-cancer drugs (2006) Current Medicinal Chemistry, 13 (29), pp. 3513-3527. , http://www.ingentaconnect.com/content/ben/cmc/2006/00000013/00000029/ art00003, DOI 10.2174/092986706779026219 | ||
| 504 | |a Rabinovich, G.A., Cumashi, A., Bianco, G.A., Ciavardelli, D., Iurisci, I., D'Egidio, M., Piccolo, E., Iacobelli, S., Synthetic lactulose amines: Novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis (2006) Glycobiology, 16 (3), pp. 210-220. , DOI 10.1093/glycob/cwj056 | ||
| 504 | |a Tejler, J., Tullberg, E., Frejd, T., Leffler, H., Nilsson, U.J., Synthesis of multivalent lactose derivatives by 1,3-dipolar cycloadditions: selective galectin-1 inhibition (2006) Carbohydrate Research, 341 (10), pp. 1353-1362. , DOI 10.1016/j.carres.2006.04.028, PII S0008621506002047 | ||
| 504 | |a Belitsky, J.M., Nelson, A., Hernandez, J.D., Baum, L.G., Stoddart, J.F., Multivalent Interactions between Lectins and Supramolecular Complexes: Galectin-1 and Self-Assembled Pseudopolyrotaxanes (2007) Chemistry and Biology, 14 (10), pp. 1140-1151. , DOI 10.1016/j.chembiol.2007.09.007, PII S1074552107003250 | ||
| 504 | |a Giguere, D., Synthesis of stable and selective inhibitors of human galectins-1 and -3 (2008) Bioorg Med Chem, 16, pp. 7811-7823 | ||
| 504 | |a Iurisci, I., Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis (2009) Anticancer Res, 20, pp. 403-410 | ||
| 504 | |a Tarner, I.H., Fathman, C.G., Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease? (2006) Nature Clinical Practice Rheumatology, 2 (9), pp. 491-499. , DOI 10.1038/ncprheum0272, PII NCPRHEUM0272 | ||
| 504 | |a Winthrop, K.L., Risk and prevention of tuberculosis and other serious opportunistic infections associated with the inhibition of tumor necrosis factor (2006) Nature Clinical Practice Rheumatology, 2 (11), pp. 602-610. , DOI 10.1038/ncprheum0336, PII NCPRHEUM0336 | ||
| 504 | |a Ozaki, K., Inoue, K., Sato, H., Iida, A., Ohnishi, Y., Sekine, A., Sato, H., Tanaka, T., Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro (2004) Nature, 429 (6987), pp. 72-75. , DOI 10.1038/nature02502 | ||
| 504 | |a Balan, V., Racial disparity in breast cancer and function germ line mutation in galectin-3 (rs4644): A pilot study (2008) Cancer Res, 68, pp. 10045-10050 | ||
| 520 | 3 | |a The immune system has evolved sophisticated mechanisms composed of several checkpoints and fail-safe processes that enable it to orchestrate innate and adaptive immunity, while at the same time limiting aberrant or unfaithful T-cell function. These multiple regulatory pathways take place during the entire life-span of T cells including T-cell development, homing, activation, and differentiation. Galectin-1, an endogenous glycan-binding protein widely expressed at sites of inflammation and tumor growth, controls a diversity of immune cell processes, acting either extracellularly through specific binding to cell surface glycan structures or intracellularly through modulation of pathways that remain largely unexplored. In this review, we highlight the discoveries that have led to our current understanding of the role of galectin-1 in distinct immune cell process, particularly those associated with T-cell homeostasis. Also, we emphasize findings emerging from the study of experimental models of autoimmunity, chronic inflammation, fetomaternal tolerance, and tumor growth, which have provided fundamental insights into the critical role of galectin-1 and its specific saccharide ligands in immunoregulation. Challenges for the future will embrace the rational manipulation of galectin-1-glycan interactions both towards attenuating immune responses in autoimmune diseases, graft rejection, and recurrent fetal loss, while at the same overcoming immune tolerance in chronic infections and cancer. © 2009 John Wiley & Sons A/S. |l eng | |
| 593 | |a Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad de Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, C1428 Ciudad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a AUTOIMMUNITY |
| 690 | 1 | 0 | |a GALECTIN-1 |
| 690 | 1 | 0 | |a GLYCOSYLATION |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a TOLERANCE |
| 690 | 1 | 0 | |a TUMOR-IMMUNE ESCAPE |
| 690 | 1 | 0 | |a CARBOHYDRATE |
| 690 | 1 | 0 | |a CELL SURFACE PROTEIN |
| 690 | 1 | 0 | |a CYTOKINE |
| 690 | 1 | 0 | |a GALECTIN 1 |
| 690 | 1 | 0 | |a GLYCAN |
| 690 | 1 | 0 | |a LIGAND |
| 690 | 1 | 0 | |a T LYMPHOCYTE RECEPTOR |
| 690 | 1 | 0 | |a ADAPTIVE IMMUNITY |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a AUTOIMMUNE DISEASE |
| 690 | 1 | 0 | |a AUTOIMMUNITY |
| 690 | 1 | 0 | |a CD25+ T LYMPHOCYTE |
| 690 | 1 | 0 | |a CD4+ T LYMPHOCYTE |
| 690 | 1 | 0 | |a CELL ACTIVATION |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL FUNCTION |
| 690 | 1 | 0 | |a CELL HOMING |
| 690 | 1 | 0 | |a CELL MIGRATION |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CHRONIC INFLAMMATION |
| 690 | 1 | 0 | |a CYTOKINE RELEASE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IMMUNE RESPONSE |
| 690 | 1 | 0 | |a IMMUNE SYSTEM |
| 690 | 1 | 0 | |a IMMUNOREGULATION |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a INNATE IMMUNITY |
| 690 | 1 | 0 | |a MACROPHAGE |
| 690 | 1 | 0 | |a MONOCYTE |
| 690 | 1 | 0 | |a NEOPLASM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN BINDING |
| 690 | 1 | 0 | |a PROTEIN CARBOHYDRATE INTERACTION |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN FUNCTION |
| 690 | 1 | 0 | |a REGULATORY T LYMPHOCYTE |
| 690 | 1 | 0 | |a REVIEW |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a T LYMPHOCYTE |
| 690 | 1 | 0 | |a TH1 CELL |
| 690 | 1 | 0 | |a TH2 CELL |
| 690 | 1 | 0 | |a TUMOR |
| 690 | 1 | 0 | |a TUMOR GROWTH |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CELL ADHESION |
| 690 | 1 | 0 | |a CELL MOVEMENT |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a GALECTIN 1 |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a LYMPHOCYTE ACTIVATION |
| 690 | 1 | 0 | |a NEOPLASMS |
| 690 | 1 | 0 | |a POLYSACCHARIDES |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a T-LYMPHOCYTE SUBSETS |
| 650 | 1 | 7 | |2 spines |a HOMEOSTASIS |
| 650 | 1 | 7 | |2 spines |a HOMEOSTASIS |
| 700 | 1 | |a Ilarregui, J.M. | |
| 773 | 0 | |d 2009 |g v. 230 |h pp. 144-159 |k n. 1 |p Immunol. Rev. |x 01052896 |w (AR-BaUEN)CENRE-5104 |t Immunological Reviews | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-67649794885&doi=10.1111%2fj.1600-065X.2009.00787.x&partnerID=40&md5=f775339cf29175fb6cced4ba625aa6e5 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1111/j.1600-065X.2009.00787.x |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01052896_v230_n1_p144_Rabinovich |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01052896_v230_n1_p144_Rabinovich |y Registro en la Biblioteca Digital |
| 961 | |a paper_01052896_v230_n1_p144_Rabinovich |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||