Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation

The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the an...

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Autor principal: Trujillo, V.
Otros Autores: Masseroni, M.L, Levin, G., Surez, M.M
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2009
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024 7 |2 cas  |a adrenalin, 51-43-4, 55-31-2, 6912-68-1; noradrenalin, 1407-84-7, 51-41-2; tianeptine, 66981-73-5; Adrenal Cortex Hormones; Antidepressive Agents, Tricyclic; Catecholamines; Thiazepines; tianeptine, 66981-73-5 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
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100 1 |a Trujillo, V. 
245 1 0 |a Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation 
260 |c 2009 
270 1 0 |m Surez, M. M.; Ctedra de Fisiologa Animal, Facultad de Ciencias Exactas, Fsicas y Naturales, Av. Vlez Srsfield 299, X5000JJC Crdoba, Argentina; email: martasuarez1@hotmail.com 
506 |2 openaire  |e Política editorial 
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520 3 |a The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.  |l eng 
593 |a Facultad de Ciencias Exactas, Fsicas y Naturales, Universidad Nacional de Crdoba, Crdoba, Argentina 
593 |a Centro de Investigaciones Endocrinolgicas (CEDIE-CONICET), Hospital de Nios R. Gutirrez, Buenos Aires, Argentina 
690 1 0 |a ANXIETY 
690 1 0 |a CATECHOLAMINES 
690 1 0 |a EARLY MATERNAL SEPARATION 
690 1 0 |a PLUS MAZE 
690 1 0 |a TIANEPTINE 
690 1 0 |a VARIABLE CHRONIC STRESS 
690 1 0 |a ADRENALIN 
690 1 0 |a NORADRENALIN 
690 1 0 |a TIANEPTINE 
690 1 0 |a ADRENALIN BLOOD LEVEL 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANXIETY 
690 1 0 |a ARTICLE 
690 1 0 |a CATECHOLAMINE BLOOD LEVEL 
690 1 0 |a CHRONIC STRESS 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a HIGH PERFORMANCE LIQUID CHROMATOGRAPHY 
690 1 0 |a LOW DRUG DOSE 
690 1 0 |a MALE 
690 1 0 |a MATERNAL DEPRIVATION 
690 1 0 |a MAZE TEST 
690 1 0 |a NONHUMAN 
690 1 0 |a NORADRENALIN BLOOD LEVEL 
690 1 0 |a RAT 
690 1 0 |a ADRENAL CORTEX HORMONES 
690 1 0 |a ADRENAL MEDULLA 
690 1 0 |a ANIMALS 
690 1 0 |a ANIMALS, NEWBORN 
690 1 0 |a ANTIDEPRESSIVE AGENTS, TRICYCLIC 
690 1 0 |a ANXIETY 
690 1 0 |a ANXIETY, SEPARATION 
690 1 0 |a BEHAVIOR, ANIMAL 
690 1 0 |a CATECHOLAMINES 
690 1 0 |a CHRONIC DISEASE 
690 1 0 |a FEMALE 
690 1 0 |a MALE 
690 1 0 |a MATERNAL DEPRIVATION 
690 1 0 |a RATS 
690 1 0 |a RATS, WISTAR 
690 1 0 |a STRESS, PSYCHOLOGICAL 
690 1 0 |a THIAZEPINES 
653 0 0 |a stablon, Servier, France 
700 1 |a Masseroni, M.L. 
700 1 |a Levin, G. 
700 1 |a Surez, M.M. 
773 0 |d 2009  |g v. 119  |h pp. 1210-1227  |k n. 8  |p Int. J. Neurosci.  |x 00207454  |w (AR-BaUEN)CENRE-5295  |t International Journal of Neuroscience 
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856 4 0 |u https://doi.org/10.1080/00207450802324713  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00207454_v119_n8_p1210_Trujillo  |y Handle 
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