Coupling of foot-and-mouth disease virus to sheep red blood cells using tannic acid for immunological assays

A technique for coupling foot-and-mouth disease virus (FMDV) to tanned sheep red blood cells (SRBC) is reported. Different parameters influencing the procedure were studied. Subtypes C2, C3, O1 and A24 were used as antigens, and guinea pig hyperimmune sera obtained were tested for specific antibody...

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Autor principal: Pujol, C.A
Otros Autores: Feledi, C.A, Massouh, E.J
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1988
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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008 140217s1988 xx ||||fo|||| 00| 0 eng|d
024 7 |2 scopus  |a 2-s2.0-0023795267 
024 7 |2 pubmed  |a 2846600 
024 7 |2 cas  |a Antigens, Viral; Tannic Acid 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a JVMED 
100 1 |a Pujol, C.A. 
245 1 0 |a Coupling of foot-and-mouth disease virus to sheep red blood cells using tannic acid for immunological assays 
260 |c 1988 
506 |2 openaire  |e Política editorial 
520 3 |a A technique for coupling foot-and-mouth disease virus (FMDV) to tanned sheep red blood cells (SRBC) is reported. Different parameters influencing the procedure were studied. Subtypes C2, C3, O1 and A24 were used as antigens, and guinea pig hyperimmune sera obtained were tested for specific antibody in passive hemagglutination (PH), passive hemagglutination inhibition (PHI) and passive immune hemolysis (PIL) assays. Fresh and SRBC stored in Alsever's solution showed similar behavior when used as indicator cells. Optimal sensitization of erythrocytes was achieved using tannic acid 1:20000 and 20 μg of purified virus/ml at pH 7.6. Specificity of the reaction was confirmed by PH and PHI in homologous and heterologous systems. The coupled antigen-antibody complex was sensitive to complement mediated lysis in a PIL test.  |l eng 
593 |a Catedra de Inmunoquimica, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 
690 1 0 |a VIRUS ANTIBODY 
690 1 0 |a VIRUS ANTIGEN 
690 1 0 |a CELL CULTURE 
690 1 0 |a FOOT AND MOUTH DISEASE VIRUS 
690 1 0 |a HEMAGGLUTINATION 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a SERUM 
690 1 0 |a ANIMAL 
690 1 0 |a ANTIGENS, VIRAL 
690 1 0 |a APHTHOVIRUS 
690 1 0 |a ERYTHROCYTES 
690 1 0 |a HEMAGGLUTINATION INHIBITION TESTS 
690 1 0 |a HEMAGGLUTINATION TESTS 
690 1 0 |a HEMOLYTIC PLAQUE TECHNIQUE 
690 1 0 |a IMMUNOLOGIC TECHNIQUES 
690 1 0 |a IN VITRO 
690 1 0 |a MICROBIOLOGICAL TECHNIQUES 
690 1 0 |a SHEEP 
690 1 0 |a SUPPORT, NON-U.S. GOV'T 
690 1 0 |a TANNIC ACID 
700 1 |a Feledi, C.A. 
700 1 |a Massouh, E.J. 
773 0 |d 1988  |g v. 20  |h pp. 275-284  |k n. 4  |p J. VIROL. METHODS  |x 01660934  |w (AR-BaUEN)CENRE-5888  |t Journal of Virological Methods 
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856 4 0 |u https://hdl.handle.net/20.500.12110/paper_01660934_v20_n4_p275_Pujol  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01660934_v20_n4_p275_Pujol  |y Registro en la Biblioteca Digital 
961 |a paper_01660934_v20_n4_p275_Pujol  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 61772