Changes in global gene expression during in vitro decidualization of rat endometrial stromal cells

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During the preimplantation phase of pregnancy the endometrial stroma differentiates into decidua, a process that implies numerous morphological changes and is an example of physiological transdifferentiation. Here we show that UIII rat endometrial stromal cells cultured in the presence of calf serum...

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Autor principal: Vallejo, G.
Otros Autores: Maschi, D., Mestre-Citrinovitz, A.C, Aiba, K., Maronna, R., Yohai, V., Ko, M.S.H, Beato, M., Saragüeta, P.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2010
Materias:
MULTIPLE ENDOCRINE NEOPLASIA 1 GENE
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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100 1 |a Vallejo, G. 
245 1 0 |a Changes in global gene expression during in vitro decidualization of rat endometrial stromal cells 
260 |c 2010 
270 1 0 |m Saragüeta, P.; Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Obligado 2490, 1428 Buenos Aires, Argentina; email: sarag@dna.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a During the preimplantation phase of pregnancy the endometrial stroma differentiates into decidua, a process that implies numerous morphological changes and is an example of physiological transdifferentiation. Here we show that UIII rat endometrial stromal cells cultured in the presence of calf serum acquired morphological features of decidual cells and expressed decidual markers. To identify genes involved in decidualization we compared gene expression patterns of control and decidualized UIII cells using cDNA microarray. We found 322 annotated genes exhibiting significant differences in expression (>3-fold, fold discovery rate (FDR) >0.005), of which 312 have not been previously related to decidualization. Analysis of overrepresented functions revealed that protein synthesis, gene expression, and chromatin architecture and remodeling are the most relevant modified functions during decidualization. Relevant genes are also found in the functional terms differentiation, cell proliferation, signal transduction, and matrix/structural proteins. Several of these new genes involved in decidualization (Csdc2, Trim27, Eef1a1, Bmp1, Wt1, Aes, Gna12, and Men1) are shown to be also regulated in uterine decidua during normal pregnancy. Thus, the UIII cell culture model will allow future mechanistic studies to define the transcriptional network regulating reprogramming of stromal cells into decidual cells. © 2009 Wiley-Liss, Inc.  |l eng 
593 |a Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Obligado 2490, 1428 Buenos Aires, Argentina 
593 |a Laboratory of Genetics, National Institute on Aging, Baltimore, MD, United States 
593 |a Departamento de Matemática, Facultad de Ciencias Exactas, Universidad Nacional de la Plata, La Plata, Argentina 
593 |a Departamento de Matemática, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 
593 |a CICPBA, La Plata, Argentina 
593 |a Centre de Regulació Genòmica, Universidad Pompeu Fabra, Barcelona, Spain 
593 |a Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 
690 1 0 |a COMPLEMENTARY DNA 
690 1 0 |a MATRIX PROTEIN 
690 1 0 |a PROCOLLAGEN C PROTEINASE 
690 1 0 |a STRUCTURAL PROTEIN 
690 1 0 |a WT1 PROTEIN 
690 1 0 |a AMINO TERMINAL SEQUENCE OF SPLIT GENE 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ARTICLE 
690 1 0 |a CELL CULTURE 
690 1 0 |a CELL PROLIFERATION 
690 1 0 |a CELL STRUCTURE 
690 1 0 |a CHROMATIN 
690 1 0 |a COLD SHOCK DOMAIN CONTAINING C2 GENE 
690 1 0 |a CYTOARCHITECTURE 
690 1 0 |a DECIDUALIZATION 
690 1 0 |a DNA MICROARRAY 
690 1 0 |a EEF1A1 GENE 
690 1 0 |a ENDOMETRIUM CELL 
690 1 0 |a FEMALE 
690 1 0 |a GENE 
690 1 0 |a GENE EXPRESSION 
690 1 0 |a GENE IDENTIFICATION 
690 1 0 |a GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA 12 GENE 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a NONHUMAN 
690 1 0 |a PREGNANCY 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN SYNTHESIS 
690 1 0 |a RAT 
690 1 0 |a SERUM 
690 1 0 |a SIGNAL TRANSDUCTION 
690 1 0 |a TRIPARTITE MOTIF CONTAINING 27 GENE 
690 1 0 |a WILMS TUMOR 1 GENE 
690 1 0 |a WT1 GENE 
690 1 0 |a ANIMALS 
690 1 0 |a CELL DIFFERENTIATION 
690 1 0 |a DECIDUA 
690 1 0 |a DOWN-REGULATION 
690 1 0 |a FEMALE 
690 1 0 |a GENE EXPRESSION PROFILING 
690 1 0 |a GENE EXPRESSION REGULATION, DEVELOPMENTAL 
690 1 0 |a OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS 
690 1 0 |a PREGNANCY 
690 1 0 |a RATS 
690 1 0 |a RATS, SPRAGUE-DAWLEY 
690 1 0 |a REPRODUCIBILITY OF RESULTS 
690 1 0 |a STROMAL CELLS 
690 1 0 |a UP-REGULATION 
690 1 0 |a RATTUS 
651 4 |a MULTIPLE ENDOCRINE NEOPLASIA 1 GENE 
700 1 |a Maschi, D. 
700 1 |a Mestre-Citrinovitz, A.C. 
700 1 |a Aiba, K. 
700 1 |a Maronna, R. 
700 1 |a Yohai, V. 
700 1 |a Ko, M.S.H. 
700 1 |a Beato, M. 
700 1 |a Saragüeta, P. 
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856 4 0 |u https://doi.org/10.1002/jcp.21929  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00219541_v222_n1_p127_Vallejo  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219541_v222_n1_p127_Vallejo  |y Registro en la Biblioteca Digital 
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