Sample preparation for sequencing hits from one-bead-one-peptide combinatorial libraries by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Optimization of bead analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) after the screening of one-bead-one-peptide combinatorial libraries was achieved, involving the fine-tuning of the whole process. Guanidine was replaced by acetonitrile (MeCN)...

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Autor principal: Martínez-Ceron, M.C
Otros Autores: Giudicessi, S.L, Marani, M.M, Albericio, F., Cascone, O., Erra-Balsells, R., Camperi, S.A
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2010
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
LEADER 08914caa a22009377a 4500
001 PAPER-7922
003 AR-BaUEN
005 20230518203742.0
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024 7 |2 scopus  |a 2-s2.0-77950689037 
024 7 |2 cas  |a acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; guanidine, 113-00-8, 25215-10-5, 50-01-1; tetrahydrofuran, 109-99-9; trifluoroacetic acid, 14477-72-6, 2923-18-4, 76-05-1; urea, 57-13-6; Acetic Acid, 64-19-7; Acetonitriles; Hydroxides; Peptide Library; Peptides; Water, 7732-18-5; acetonitrile, 75-05-8; ammonium hydroxide, 1336-21-6 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a ANBCA 
100 1 |a Martínez-Ceron, M.C. 
245 1 0 |a Sample preparation for sequencing hits from one-bead-one-peptide combinatorial libraries by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry 
260 |c 2010 
270 1 0 |m Camperi, S.A.; Cátedra de Microbiología Industrial y Biotecnología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina; email: scamperi@ffyb.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V.J., Kazmierski, W.M., A new type of synthetic peptide library for identifying ligand-binding activity (1991) Nature, 354, pp. 82-84 
504 |a Lam, K.S., Lehman, A.L., Song, A., Doan, N., Enstrom, A.M., Maxwell, J., Liu, R., Synthesis and screening of " one-bead one-compound" combinatorial peptide libraries (2003) Methods in Enzymology, 369, pp. 298-322. , Academic Press, San Diego 
504 |a Aina, O.H., Liu, R., Sutcliffe, J.L., Marik, J., Pan, C.X., Lam, K.S., From combinatorial chemistry to cancer-targeting peptides (2007) Mol. Pharm., 4, pp. 631-651 
504 |a Camperi, S.A., Iannucci, N.B., Albanesi, G.J., Oggero Eberhardt, M., Etcheverrigaray, M., Messeguer, A., Albericio, F., Cascone, O., Monoclonal antibody purification by affinity chromatography with ligands derived from the screening of peptide combinatory libraries (2003) Biotechnol. Lett., 25, pp. 1545-1548 
504 |a Camperi, S.A., Marani, M.M., Iannucci, N.B., Côté, S., Albericio, F., Cascone, O., An efficient strategy for the preparation of one-bead-one-peptide libraries on a new biocompatible solid support (2005) Tetrahedron Lett., 46, pp. 1561-1564 
504 |a Marani, M.M., Oliveira, E., Côté, S., Camperi, S.A., Albericio, F., Cascone, O., Identification of protein-binding peptides by direct MALDI-TOF-MS analysis of peptide beads selected from the screening of one-bead-one-peptide combinatorial libraries (2007) Anal. Biochem., 370, pp. 215-222 
504 |a Marani, M.M., Martínez Ceron, M.C., Giudicessi, S.L., Oliveira, E., Côté, S., Erra-Balsells, R., Albericio, F., Camperi, S.A., Screening of one-bead-one-peptide combinatorial library using red fluorescent dyes: presence of positive and false positive beads (2009) J. Comb. Chem., 11, pp. 146-150 
504 |a Atherton, E., Logan, C.J., Sheppard, R.C., Peptide synthesis: II. Procedures for solid-phase synthesis using N-α-fluorenylmethoxycarbonylamino-acids on polyamide supports: synthesis of substance P and of acyl carrier protein 65-74 decapeptide (1981) J. Chem. Soc. Perkin Trans., 1, pp. 538-546 
504 |a Bray, A.M., Valerio, R.M., Maeji, N.J., Cleavage of resin-bound peptide esters with ammonia vapour: simultaneous multiple synthesis of peptide amides (1993) Tetrahedron Lett., 34, pp. 4411-4414 
504 |a García-Martín, F., Quintanar-Audelo, M., García-Ramos, Y., Cruz, L.J., Gravel, C., Furic, R., Côté, S., Albericio, F., ChemMatrix, a poly(ethylene glycol)-based support for the solid-phase synthesis of complex peptides (2006) J. Comb. Chem., 8, pp. 213-220 
504 |a Nonami, H., Fukui, S., Erra-Balsells, R., β-Carboline alkaloids as matrices for matrix-assisted ultraviolet laser desorption time-of-flight mass spectrometry of proteins and sulfated oligosaccharides: a comparative study using phenylcarbonyl compounds, carbazoles, and classical matrices (1997) J. Mass Spectrom., 32, pp. 287-296 
504 |a Nishikaze, T., Takayama, M., Disappearance of interfering alkali-metal adducted peaks from matrix-assisted laser desorption/ionization mass spectra of peptides with serine addition to α-cyano-4-hydroxycinnamic acid matrix (2007) Rapid Commun. Mass Spectrom., 21, pp. 3345-3351 
504 |a Zhu, X., Papayannopoulos, I.A., Improvement in the detection of low concentration protein digests on a MALDI TOF/TOF workstation by reducing α-cyano-4-hydroxycinnamic acid adduct ions (2003) J. Biomol. Tech., 14, pp. 298-307 
520 3 |a Optimization of bead analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) after the screening of one-bead-one-peptide combinatorial libraries was achieved, involving the fine-tuning of the whole process. Guanidine was replaced by acetonitrile (MeCN)/acetic acid (AcOH)/water (H2O), improving matrix crystallization. Peptide-bead cleavage with NH4OH was cheaper and safer than, yet as efficient as, NH3/tetrahydrofuran (THF). Peptide elution in microtubes instead of placing the beads in the sample plate yielded more sample aliquots. Successive dry layers deposit sample preparation was better than the dried droplet method. Among the matrices analyzed, α-cyano-4-hydroxycinnamic acid resulted in the best peptide ion yield. Cluster formation was minimized by the addition of additives to the matrix. © 2010 Elsevier Inc.  |l eng 
536 |a Detalles de la financiación: Umweltbundesamt 
536 |a Detalles de la financiación: Generalitat de Catalunya, 2009SGR 1024 
536 |a Detalles de la financiación: Comisión Interministerial de Ciencia y Tecnología, CTQ2009-07758 
536 |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas 
536 |a Detalles de la financiación: This study was partially supported by CONICET , ANPCyT , UBA , CICYT ( CTQ2009-07758 ) and the Generalitat de Catalunya ( 2009SGR 1024 ). M.M.M., R.E.-B., O.C., and S.A.C. are researchers at CONICET. The Ultraflex II-TOF/TOF instrument was provided by ANPCyT, PME125. We thank Simon Côté (Matrix Innovation) for the donation of HMBA–ChemMatrix resin and thank Marta Paradis-Bas (Barcelona Science Park) for excellent technical assistance. Appendix A 
593 |a Cátedra de Microbiología Industrial y Biotecnología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina 
593 |a CIHDECAR-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina 
593 |a IRB Barcelona, CIBER-BBN, 08028 Barcelona, Spain 
593 |a Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain 
690 1 0 |a ACETIC ACID 
690 1 0 |a GUANIDINE 
690 1 0 |a TETRAHYDROFURAN 
690 1 0 |a TRIFLUOROACETIC ACID 
690 1 0 |a UREA 
690 1 0 |a AMBIENT AIR 
690 1 0 |a ARTICLE 
690 1 0 |a CRYSTALLIZATION 
690 1 0 |a ELUTION 
690 1 0 |a IONIZATION 
690 1 0 |a MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY 
690 1 0 |a PEPTIDE ANALYSIS 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROCESS OPTIMIZATION 
690 1 0 |a SENSITIVITY ANALYSIS 
690 1 0 |a TANDEM MASS SPECTROMETRY 
690 1 0 |a ACETIC ACID 
690 1 0 |a ACETONITRILES 
690 1 0 |a HYDROXIDES 
690 1 0 |a PEPTIDE LIBRARY 
690 1 0 |a PEPTIDES 
690 1 0 |a SEQUENCE ANALYSIS, PROTEIN 
690 1 0 |a SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION 
690 1 0 |a WATER 
700 1 |a Giudicessi, S.L. 
700 1 |a Marani, M.M. 
700 1 |a Albericio, F. 
700 1 |a Cascone, O. 
700 1 |a Erra-Balsells, R. 
700 1 |a Camperi, S.A. 
773 0 |d 2010  |g v. 400  |h pp. 295-297  |k n. 2  |p Anal. Biochem.  |x 00032697  |w (AR-BaUEN)CENRE-163  |t Analytical Biochemistry 
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