Electronic tongue for simultaneous detection of endotoxins and other contaminants of microbiological origin

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Endotoxins, also referred to as pyrogens, are lipopolysaccharides (LPS) present in the outer membrane of Gram-negative bacteria, and represent one of the most dangerous microbiological contaminants in water for hemodialysis and intravenous infusion. A method is presented for the simultaneous detecti...

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Autor principal: Heras, J.Y
Otros Autores: Pallarola, D., Battaglini, Fernando
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2010
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-77953361726 
024 7 |2 cas  |a amino acid, 65072-01-7; protein, 67254-75-5; Complex Mixtures; Endotoxins; Lipopolysaccharides; Complex Mixtures; Endotoxins; Lipopolysaccharides 
030 |a BBIOE 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
100 1 |a Heras, J.Y. 
245 1 0 |a Electronic tongue for simultaneous detection of endotoxins and other contaminants of microbiological origin 
260 |c 2010 
270 1 0 |m Battaglini, F.; INQUIMAE - Departamento de Química Inorgánica, Analítica y Química Física, Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina; email: battagli@qi.fcen.uba.ar 
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504 |a Riul, A., Malmegrim, R.R., Fonseca, F.J., Mattoso, L.H.C., (2003) Biosens. Bioelectron., 18, pp. 1365-1369 
504 |a Schindler, R., (2009) Blood Purif., 27 (SUPPL. 1), pp. 20-22 
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504 |a Scott, S.M., James, D., Ali, D., (2006) Microchim. Acta, 156 (2006), pp. 183-207 
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506 |2 openaire  |e Política editorial 
520 3 |a Endotoxins, also referred to as pyrogens, are lipopolysaccharides (LPS) present in the outer membrane of Gram-negative bacteria, and represent one of the most dangerous microbiological contaminants in water for hemodialysis and intravenous infusion. A method is presented for the simultaneous detection of endotoxins and other bacterial lysis contaminating species in purified water for parenteral formulations. The technique used is electrochemical impedance spectroscopy, with data interpretation using principal component analysis (PCA), cluster analysis (CA), and multivariate discriminant analysis (MDA). Two types of electrode surfaces were modified with LPS recognition agents: (i) a 37 amino acids fragment of a 18. kDa cationic antimicrobial protein (CAP18F) that has LPS binding activity; (ii) the highly selective endotoxin neutralizing protein (ENP). Statistical multivariate analysis of the impedance spectral data allowed the detection of endotoxin at, and below, the threshold pharmaceutical regulatory level. Discrimination of LPS from samples containing proteins, nucleic acids, phospholipids or their mixtures was achieved. These results open a new route to a practical instrumental method capable of detecting and discriminating LPS from other potential pro-inflammatory species of microbiological origin, such as nucleic acids. © 2010 Elsevier B.V.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires 
536 |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT 00575 
536 |a Detalles de la financiación: Universidad de Buenos Aires and ANPCyT (PICT 00575) are acknowledged for financial support. FB is research staff member of CONICET. Appendix A 
593 |a INQUIMAE - Departamento de Química Inorgánica, Analítica y Química Física, Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina 
593 |a Instituto de Investigaciones Fiscoquímicas Teóricas y Aplicadas (INIFTA), CONICET, Universidad Nacional de La Plata, CC. 16 Suc. 4, La Plata 1900, Argentina 
690 1 0 |a ELECTRONIC TONGUE 
690 1 0 |a ENDOTOXIN DETECTION 
690 1 0 |a IMPEDANCE SPECTROSCOPY 
690 1 0 |a PRINCIPAL COMPONENT ANALYSIS 
690 1 0 |a PRO-INFLAMMATORY MOLECULES 
690 1 0 |a ANTIMICROBIAL PROTEINS 
690 1 0 |a BACTERIAL LYSIS 
690 1 0 |a BINDING ACTIVITIES 
690 1 0 |a DATA INTERPRETATION 
690 1 0 |a ELECTRODE SURFACES 
690 1 0 |a ELECTRONIC TONGUE 
690 1 0 |a ENDOTOXIN DETECTION 
690 1 0 |a ENDOTOXIN NEUTRALIZING 
690 1 0 |a GRAM-NEGATIVE BACTERIA 
690 1 0 |a IMPEDANCE SPECTROSCOPY 
690 1 0 |a INFLAMMATORY SPECIES 
690 1 0 |a INSTRUMENTAL METHODS 
690 1 0 |a LIPOPOLYSACCHARIDES 
690 1 0 |a MULTI VARIATE ANALYSIS 
690 1 0 |a MULTIVARIATE DISCRIMINANT ANALYSIS 
690 1 0 |a OUTER MEMBRANE 
690 1 0 |a PURIFIED WATER 
690 1 0 |a REGULATORY LEVEL 
690 1 0 |a SIMULTANEOUS DETECTION 
690 1 0 |a SPECTRAL DATA 
690 1 0 |a AMINO ACIDS 
690 1 0 |a BACTERIA 
690 1 0 |a BACTERIOLOGY 
690 1 0 |a CLUSTER ANALYSIS 
690 1 0 |a DECISION MAKING 
690 1 0 |a DIALYSIS 
690 1 0 |a DISCRIMINANT ANALYSIS 
690 1 0 |a DRUG PRODUCTS 
690 1 0 |a ELECTROCHEMICAL CORROSION 
690 1 0 |a ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY 
690 1 0 |a ELECTRODES 
690 1 0 |a ELECTRONIC TONGUES 
690 1 0 |a MULTIVARIANT ANALYSIS 
690 1 0 |a NUCLEIC ACIDS 
690 1 0 |a ORGANIC ACIDS 
690 1 0 |a PHOSPHOLIPIDS 
690 1 0 |a PROTEINS 
690 1 0 |a SPECTRUM ANALYSIS 
690 1 0 |a PRINCIPAL COMPONENT ANALYSIS 
690 1 0 |a AMINO ACID 
690 1 0 |a CATIONIC ANTIMICROBIAL PROTEIN 
690 1 0 |a ENDOTOXIN 
690 1 0 |a ENDOTOXIN NEUTRALIZING PROTEIN 
690 1 0 |a LIPOPOLYSACCHARIDE 
690 1 0 |a NUCLEIC ACID 
690 1 0 |a PHOSPHOLIPID 
690 1 0 |a PROTEIN 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a BIOMIMETIC MATERIAL 
690 1 0 |a DRUG MIXTURE 
690 1 0 |a ENDOTOXIN 
690 1 0 |a LIPOPOLYSACCHARIDE 
690 1 0 |a ARTICLE 
690 1 0 |a BACTERIUM CONTAMINATION 
690 1 0 |a CLUSTER ANALYSIS 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DISCRIMINANT ANALYSIS 
690 1 0 |a ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY 
690 1 0 |a ELECTRODE 
690 1 0 |a ELECTRONICS 
690 1 0 |a NONHUMAN 
690 1 0 |a PRINCIPAL COMPONENT ANALYSIS 
690 1 0 |a PROTEIN BINDING 
690 1 0 |a TONGUE 
690 1 0 |a TOXIN ANALYSIS 
690 1 0 |a ANALYSIS 
690 1 0 |a CONDUCTOMETRY 
690 1 0 |a DEVICE FAILURE ANALYSIS 
690 1 0 |a DEVICES 
690 1 0 |a DRUG MIXTURE 
690 1 0 |a EQUIPMENT DESIGN 
690 1 0 |a EVALUATION STUDY 
690 1 0 |a GENETIC PROCEDURES 
690 1 0 |a METABOLISM 
690 1 0 |a REPRODUCIBILITY 
690 1 0 |a SALMONELLA ENTERICA 
690 1 0 |a SENSITIVITY AND SPECIFICITY 
690 1 0 |a BIOMIMETIC MATERIALS 
690 1 0 |a BIOSENSING TECHNIQUES 
690 1 0 |a COMPLEX MIXTURES 
690 1 0 |a CONDUCTOMETRY 
690 1 0 |a ENDOTOXINS 
690 1 0 |a EQUIPMENT DESIGN 
690 1 0 |a EQUIPMENT FAILURE ANALYSIS 
690 1 0 |a LIPOPOLYSACCHARIDES 
690 1 0 |a REPRODUCIBILITY OF RESULTS 
690 1 0 |a SALMONELLA ENTERICA 
690 1 0 |a SENSITIVITY AND SPECIFICITY 
690 1 0 |a TONGUE 
690 1 0 |a BACTERIA (MICROORGANISMS) 
690 1 0 |a NEGIBACTERIA 
690 1 0 |a BIOMIMETIC MATERIALS 
690 1 0 |a BIOSENSING TECHNIQUES 
690 1 0 |a COMPLEX MIXTURES 
690 1 0 |a CONDUCTOMETRY 
690 1 0 |a ENDOTOXINS 
690 1 0 |a EQUIPMENT DESIGN 
690 1 0 |a EQUIPMENT FAILURE ANALYSIS 
690 1 0 |a LIPOPOLYSACCHARIDES 
690 1 0 |a REPRODUCIBILITY OF RESULTS 
690 1 0 |a SALMONELLA ENTERICA 
690 1 0 |a SENSITIVITY AND SPECIFICITY 
690 1 0 |a TONGUE 
700 1 |a Pallarola, D. 
700 1 |a Battaglini, Fernando 
773 0 |d 2010  |g v. 25  |h pp. 2470-2476  |k n. 11  |p Biosens. Bioelectron.  |x 09565663  |w (AR-BaUEN)CENRE-4000  |t Biosensors and Bioelectronics 
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856 4 0 |u https://doi.org/10.1016/j.bios.2010.04.004  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_09565663_v25_n11_p2470_Heras  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09565663_v25_n11_p2470_Heras  |y Registro en la Biblioteca Digital 
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