Genetic analysis of six communities of Mbyá-Guaraní inhabiting Northeastern Argentina by means of nuclear and mitochondrial polymorphic markers
Autosomal STRs, Y-chromosome markers, and mitochondrial DNA sequences were investigated in six Mbyá-Guaraní villages (Fortín M'Bororé, Yryapu, Tabay, Kaaguy Poty, Jejy, and Yaboti), all of them settled within the province of Misiones, northeastern Argentina. One hundred twenty-one unrelated ind...
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2010
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024 | 7 | |2 pubmed |a 21082911 | |
024 | 7 | |2 cas |a DNA, Mitochondrial | |
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100 | 1 | |a Sala, A. | |
245 | 1 | 0 | |a Genetic analysis of six communities of Mbyá-Guaraní inhabiting Northeastern Argentina by means of nuclear and mitochondrial polymorphic markers |
260 | |c 2010 | ||
270 | 1 | 0 | |m Sala, A.; Servicio de Huellas Digitales Geneticas y Catedra de Genetica y Biologia Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina |
506 | |2 openaire |e Política editorial | ||
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520 | 3 | |a Autosomal STRs, Y-chromosome markers, and mitochondrial DNA sequences were investigated in six Mbyá-Guaraní villages (Fortín M'Bororé, Yryapu, Tabay, Kaaguy Poty, Jejy, and Yaboti), all of them settled within the province of Misiones, northeastern Argentina. One hundred twenty-one unrelated individuals were analyzed. The study involved typing fifteen autosomal STRs, nine Y-chromosome STRs, and four biallele loci in the nonrecombinant region of the Y chromosome, sequencing the mtDNA of hypervariable regions I and II, and detecting the 9-bp ins/del in region V of mtDNA. All autosomal STRs were in Hardy-Weinberg equilibrium. The four major native American mtDNA haplogroups were represented in the sample. Haplogroups A2 and D1 exhibited the highest frequencies (40.5% and 36.0%, respectively), and haplogroups B2 and C1 appeared to be less frequent (17.5% and 6.0%, respectively). The native American haplogroup Q1a3a was observed in a relevant proportion (88.8%). In addition, a nine-STR Y-chromosome haplotype (DYS19*13, DYS389I*14, DYS389II*31, DYS390*24, DYS391*11, DYS392*14, DYS393*11, DYS385A*14, DYS385B*16) exhibited a frequency of more than 36%. Our results indicate that the analyzed Argentinean Guaraní individuals are genetically more closely related to Guaraní from Brazil [genetic distance (.μ)2 = 0.48] than to other related tribes that are geographically closer. Statistical approaches based on autosomal data do not support the hypothesis of genetic drift previously proposed; however, this apparent discrepancy might be due to the lack of sensitivity of the autosomal markers used here. © 2010 Wayne State University Press. |l eng | |
593 | |a Servicio de Huellas Digitales Geneticas y Catedra de Genetica y Biologia Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
593 | |a Laboratorio de Citogenética y Genética Humana, Facultad de Ciencias Exactas,Químicas y Naturales, Universidad Nacional de Misiones, Misiones, Argentina | ||
593 | |a Laboratorio de Análisis de ADN, Facultad de Ciencias Médicas, Universidad de Cuyo, Mendoza, Argentina | ||
690 | 1 | 0 | |a AUTOSOMAL STRS |
690 | 1 | 0 | |a MBYA-GUARANI |
690 | 1 | 0 | |a MTDNA |
690 | 1 | 0 | |a NATIVE SOUTH AMERINDIAN |
690 | 1 | 0 | |a Y-CHROMOSOME STRS |
690 | 1 | 0 | |a MICROSATELLITE DNA |
690 | 1 | 0 | |a MITOCHONDRIAL DNA |
690 | 1 | 0 | |a ARTICLE |
690 | 1 | 0 | |a CELL NUCLEUS |
690 | 1 | 0 | |a FEMALE |
690 | 1 | 0 | |a GENETICS |
690 | 1 | 0 | |a HUMAN |
690 | 1 | 0 | |a MALE |
690 | 1 | 0 | |a POPULATION GENETICS |
690 | 1 | 0 | |a Y CHROMOSOME |
690 | 1 | 0 | |a CELL NUCLEUS |
690 | 1 | 0 | |a CHROMOSOMES, HUMAN, Y |
690 | 1 | 0 | |a DNA, MITOCHONDRIAL |
690 | 1 | 0 | |a FEMALE |
690 | 1 | 0 | |a GENETICS, POPULATION |
690 | 1 | 0 | |a HUMANS |
690 | 1 | 0 | |a MALE |
690 | 1 | 0 | |a MICROSATELLITE REPEATS |
651 | 4 | |a AMERICAN INDIAN | |
651 | 4 | |a ARGENTINA | |
651 | 4 | |a ARGENTINA | |
651 | 4 | |a INDIANS, NORTH AMERICAN | |
700 | 1 | |a Argüelles, C.F. | |
700 | 1 | |a Marino, M.E. | |
700 | 1 | |a Bobillo, C. | |
700 | 1 | |a Fenocchio, A. | |
700 | 1 | |a Corach, D. | |
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