Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate

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In the postgenomic era, the study of the glycome-the whole repertoire of saccharides in cells and tissues-has enabled the association of unique glycan structures with specific physiological and pathological processes. The responsibility for deciphering this biological information belongs to endogeno...

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Autor principal: Cooper, D.
Otros Autores: Ilarregui, J.M, Pesoa, S.A, Croci, D.O, Perretti, M., Rabinovich, G.A
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Publicado: 2010
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024 7 |2 scopus  |a 2-s2.0-77956156950 
024 7 |2 cas  |a galectin 1, 258495-34-0; Galectin 1 
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030 |a MENZA 
100 1 |a Cooper, D. 
245 1 0 |a Multiple functional targets of the immunoregulatory activity of Galectin-1. Control of immune cell trafficking, dendritic cell physiology, and T-cell fate 
260 |c 2010 
270 1 0 |m Cooper, D.; The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom 
506 |2 openaire  |e Política editorial 
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520 3 |a In the postgenomic era, the study of the glycome-the whole repertoire of saccharides in cells and tissues-has enabled the association of unique glycan structures with specific physiological and pathological processes. The responsibility for deciphering this biological information belongs to endogenous glycan-binding proteins or lectins. Galectin-1, a prototypic member of a family of structurally related proteins, has demonstrated selective antiinflammatory and immunoregulatory effects either by controlling immune cell trafficking, "fine-tuning" dendritic cell physiology and regulating T-cell fate. These regulatory functions mediated by an endogenous glycan-binding protein may contribute to fulfill the needs for immune cell homeostasis, including preservation of fetomaternal tolerance and prevention of collateral damage as a result of microbial invasion or autoimmune pathology. We will discuss here the conceptual framework which led to the study of galectin-glycan lattices as a novel paradigm of immune cell communication in physiological and pathological processes and will highlight selected methods and experimental strategies which have contributed to the study of the immunoregulatory activities of this multifaceted glycan-binding protein both in in vitro and in vivo biological settings. © 2010 Elsevier Inc.  |l eng 
536 |a Detalles de la financiación: PICT 2006-603 
536 |a Detalles de la financiación: Arthritis Research UK, 18103 
536 |a Detalles de la financiación: Work in authors' laboratories is supported by grants from The Argentinean Agency for Promotion of Science and Technology (PICT 2006-603; Argentina), Sales Foundation for Cancer Research (Argentina), The Cancer Research Institute (USA), and The Prostate Cancer Research Foundation (UK) to G. A. R., Arthritis Research UK fellowship to D. C. (18103) and the William Harvey Research Foundation to D. C. and M. P. We thank all members of our laboratories, especially M. Toscano for critical reading of the manuscript. 
593 |a The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom 
593 |a Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina 
593 |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 
690 1 0 |a DENDRITIC CELLS 
690 1 0 |a GALECTIN-1 
690 1 0 |a GLYCOIMMUNOLOGY 
690 1 0 |a INFLAMMATION 
690 1 0 |a NEUTROPHILS 
690 1 0 |a T CELLS 
690 1 0 |a TOLERANCE 
690 1 0 |a TRAFFICKING 
690 1 0 |a GALECTIN 1 
690 1 0 |a ADOPTIVE TRANSFER 
690 1 0 |a ANTIINFLAMMATORY ACTIVITY 
690 1 0 |a ARTICLE 
690 1 0 |a AUTOIMMUNE DISEASE 
690 1 0 |a BINDING ASSAY 
690 1 0 |a CARBOHYDRATE ANALYSIS 
690 1 0 |a CELL COUNT 
690 1 0 |a CELL CULTURE 
690 1 0 |a CELL DEATH 
690 1 0 |a CELL DIFFERENTIATION 
690 1 0 |a CELL FATE 
690 1 0 |a CELL FUNCTION 
690 1 0 |a CELL ISOLATION 
690 1 0 |a CELL MATURATION 
690 1 0 |a CELL MIGRATION 
690 1 0 |a CELL POLARITY 
690 1 0 |a CELL SURFACE 
690 1 0 |a CELL SURVIVAL 
690 1 0 |a CHEMOTAXIS 
690 1 0 |a CONCEPTUAL FRAMEWORK 
690 1 0 |a CREMASTER MUSCLE 
690 1 0 |a DENDRITIC CELL 
690 1 0 |a DISEASE MODEL 
690 1 0 |a ENDOCYTOSIS 
690 1 0 |a ENDOTHELIUM CELL 
690 1 0 |a HELPER CELL 
690 1 0 |a HUMAN 
690 1 0 |a IMMUNOLOGICAL TOLERANCE 
690 1 0 |a IMMUNOREGULATION 
690 1 0 |a LEUKOCYTE 
690 1 0 |a MESENTERY 
690 1 0 |a MICROVASCULATURE 
690 1 0 |a MOTHER FETUS RELATIONSHIP 
690 1 0 |a NONHUMAN 
690 1 0 |a PERITONITIS 
690 1 0 |a PHENOTYPE 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN FUNCTION 
690 1 0 |a QUANTITATIVE ANALYSIS 
690 1 0 |a REAL TIME POLYMERASE CHAIN REACTION 
690 1 0 |a REGULATORY MECHANISM 
690 1 0 |a T LYMPHOCYTE 
690 1 0 |a TH1 CELL 
690 1 0 |a TH17 CELL 
690 1 0 |a TH2 CELL 
690 1 0 |a WESTERN BLOTTING 
690 1 0 |a ANIMALS 
690 1 0 |a CHEMOTAXIS, LEUKOCYTE 
690 1 0 |a DENDRITIC CELLS 
690 1 0 |a GALECTIN 1 
690 1 0 |a HUMANS 
690 1 0 |a IMMUNE SYSTEM 
690 1 0 |a IMMUNOMODULATION 
690 1 0 |a LABORATORY TECHNIQUES AND PROCEDURES 
690 1 0 |a MODELS, BIOLOGICAL 
690 1 0 |a T-LYMPHOCYTES 
650 1 7 |2 spines  |a HOMEOSTASIS 
650 1 7 |2 spines  |a HOMEOSTASIS 
700 1 |a Ilarregui, J.M. 
700 1 |a Pesoa, S.A. 
700 1 |a Croci, D.O. 
700 1 |a Perretti, M. 
700 1 |a Rabinovich, G.A. 
773 0 |d 2010  |g v. 480  |h pp. 199-244  |k n. C  |p Methods Enzymol.  |x 00766879  |w (AR-BaUEN)CENRE-793  |t Methods in Enzymology 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956156950&doi=10.1016%2fS0076-6879%2810%2980011-4&partnerID=40&md5=98fee6840b8834e88ca8ac200fccafd1  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.1016/S0076-6879(10)80011-4  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00766879_v480_nC_p199_Cooper  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00766879_v480_nC_p199_Cooper  |y Registro en la Biblioteca Digital 
961 |a paper_00766879_v480_nC_p199_Cooper  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 68613 

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