Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors
The perinatal development of the nervous system is influenced by different external and internal stimuli. Previous data show that maternal care and perinatal inflammation can induce long-term changes in anxiety- and depression-related behavior. Our hypothesis is that both maternal care and perinatal...
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2010
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| LEADER | 21214caa a22018257a 4500 | ||
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| 001 | PAPER-7549 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203717.0 | ||
| 008 | 190411s2010 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-77953363512 | |
| 024 | 7 | |2 cas |a corticosterone, 50-22-6; Corticosterone, 50-22-6; Lipopolysaccharides | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRED | ||
| 100 | 1 | |a Lucchina, L. | |
| 245 | 1 | 0 | |a Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors |
| 260 | |c 2010 | ||
| 270 | 1 | 0 | |m Depino, A.M.; Instituto de Fisiolologia, Biologia Molecular y Neurociencias, Ciudad Universitaria - Pabellon II - 2do piso, C1428EHA Buenos Aires, Argentina; email: adepino@conicet.gov.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The perinatal development of the nervous system is influenced by different external and internal stimuli. Previous data show that maternal care and perinatal inflammation can induce long-term changes in anxiety- and depression-related behavior. Our hypothesis is that both maternal care and perinatal inflammation act through interacting biological pathways to program adult behavior. To evaluate this interaction, we combined a protocol of maternal care variation in mice (C57BL/6J × BALB/c reciprocal F1 offspring) with the administration of bacterial wall lipopolysaccharide (LPS) at a previously reported sensitive development age (postnatal day 3, P3). The analysis of maternal behavior revealed that pups from C57BL/6J dams received more maternal attention than those taken care by BALB/c dams. Pups receiving LPS at P3 showed an acute corticosterone response, and a dose-dependent desensitization of this hormonal response when challenged with LPS at adulthood. We analyzed adult behavior on 6 highly validated tests and found an interaction between maternal care and early postnatal LPS on 7 anxiety-related behaviors in 4 different tests. In particular, early postnatal LPS treatment resulted in higher anxiety-related behavior when administered to females receiving more maternal care (C57 pedigree), but reduced depression-related behavior in males of the same pedigree. These results suggest that specific coping strategies are sensitive to maternal care and/or postnatal inflammation programming of adult anxiety- and depression-related behaviors, suggesting that both divergent and convergent mechanisms participate in this programming. © 2010 Elsevier B.V. |l eng | |
| 593 | |a Instituto de Fisiolologia, Biologia Molecular y Neurociencias, CONICET-UBA, C1428EHA Buenos Aires, Argentina | ||
| 593 | |a Santa Lucia Foundation, European Centre for Brain Research, Via Fosso del Fiorano, 00143 Rome, Italy | ||
| 593 | |a Department of Psychology, University La Sapienza, 00185 Rome, Italy | ||
| 593 | |a Leloir Institute Foundation, Instituto de Investigaciones Bioquimicas Buenos Aires, CONICET, 1405 Buenos Aires, Argentina | ||
| 593 | |a Departamento de Fisiologia y Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANXIETY BEHAVIOR |
| 690 | 1 | 0 | |a DEPRESSION BEHAVIOR |
| 690 | 1 | 0 | |a F1 HYBRIDS |
| 690 | 1 | 0 | |a MATERNAL CARE |
| 690 | 1 | 0 | |a POSTNATAL INFLAMMATION |
| 690 | 1 | 0 | |a PRINCIPAL COMPONENT ANALYSIS |
| 690 | 1 | 0 | |a PROGRAMMING OF ADULT BEHAVIOR |
| 690 | 1 | 0 | |a BACTERIUM LIPOPOLYSACCHARIDE |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a ADULTHOOD |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANXIETY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a ATTENTION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a COPING BEHAVIOR |
| 690 | 1 | 0 | |a DEPRESSION |
| 690 | 1 | 0 | |a DESENSITIZATION |
| 690 | 1 | 0 | |a DEVELOPMENTAL STAGE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a MATERNAL BEHAVIOR |
| 690 | 1 | 0 | |a MATERNAL CARE |
| 690 | 1 | 0 | |a MOTHER CHILD RELATION |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PEDIGREE |
| 690 | 1 | 0 | |a PERINATAL PERIOD |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a VALIDATION PROCESS |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, NEWBORN |
| 690 | 1 | 0 | |a ANXIETY |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a DEPRESSION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDES |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MATERNAL BEHAVIOR |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a MICE, INBRED C57BL |
| 690 | 1 | 0 | |a NEUROPSYCHOLOGICAL TESTS |
| 690 | 1 | 0 | |a RANDOM ALLOCATION |
| 690 | 1 | 0 | |a SEX FACTORS |
| 700 | 1 | |a Carola, V. | |
| 700 | 1 | |a Pitossi, F. | |
| 700 | 1 | |a Depino, A.M. | |
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