A caged nicotine with nanosecond range kinetics and visible light sensitivity
We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 06938caa a22010817a 4500 | ||
|---|---|---|---|
| 001 | PAPER-7448 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203711.0 | ||
| 008 | 190411s2010 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-77957167416 | |
| 024 | 7 | |2 cas |a bipyridine, 37275-48-2; nicotine, 54-11-5; ruthenium, 7440-18-8; Nicotine, 54-11-5; Ruthenium, 7440-18-8 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JIBID | ||
| 100 | 1 | |a Filevich, O. | |
| 245 | 1 | 2 | |a A caged nicotine with nanosecond range kinetics and visible light sensitivity |
| 260 | |c 2010 | ||
| 270 | 1 | 0 | |m Etchenique, R.; Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2 Piso 3, C1428EHA, Buenos Aires, Argentina; email: rober@qi.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a (1988) U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Health Promotion and Education, Office on Smoking and Health, , U.S. Department of Health and Human Services, DHHS, Publication No. (CDC) 88-8406 | ||
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| 504 | |a Zayat, L., Baraldo, L., Etchenique, R., (2005) Imaging in Neuroscience and Development. A Laboratory Manual, pp. 367-424. , Cold Spring Harbor Laboratory Press, New York, R. Yuste, A. Konnerth (Eds.) | ||
| 504 | |a Pettit, D.L., Wang, S.S.H., Gee, K.R., Augustine, G.J., (1997) Neuron, 19, pp. 465-471 | ||
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| 504 | |a Zayat, L., Noval, M.G., Campi, J., Calero, C.I., Calvo, D.J., Etchenique, R., (2007) Chembiochem, 8, pp. 2035-2038 | ||
| 504 | |a Salierno, M., Marceca, E., Peterka, D.S., Yuste, R., Etchenique, R., (2010) J. Inorg. Biochem., 104, pp. 418-422 | ||
| 504 | |a Zayat, L., Salierno, M., Etchenique, R., (2006) Inorg. Chem., 45, pp. 1728-1731 | ||
| 504 | |a Campagna, S., Puntoriero, F., Nastasi, F., Bergamini, G., Balzani, V., (2007) Top. Curr. Chem., 280, pp. 117-214 | ||
| 504 | |a Viala, C., Coudret, C., (2005) Inorg. Chim. Acta, 359, p. 984 | ||
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| 520 | 3 | |a We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with biologically harmless, blue (473nm) or green (532nm) light. The photolysis reaction is clean and very fast, with a time constant of 17ns. The synthesis is simple and the obtained compound is characterized by NMR, UV-Vis spectroscopy and cyclic voltametry. We find that this compound is active in biological systems, being able to elicit action potentials in leech neurons. © 2010 Elsevier Inc. |l eng | |
| 536 | |a Detalles de la financiación: Secretaría de Ciencia y Técnica, Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: We are grateful to Dr. Lidia Szczupak for providing the leeches. This work was done with funding from UBACyT , CONICET and ANPCyT . RE is a member of CONICET. | ||
| 593 | |a Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2 Piso 3, C1428EHA, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CAGED COMPOUND |
| 690 | 1 | 0 | |a LEECH |
| 690 | 1 | 0 | |a NACHR |
| 690 | 1 | 0 | |a NEUROTRANSMITTER |
| 690 | 1 | 0 | |a NICOTINE |
| 690 | 1 | 0 | |a RUTHENIUM COMPLEX |
| 690 | 1 | 0 | |a BIPYRIDINE |
| 690 | 1 | 0 | |a CAGED NICOTINE |
| 690 | 1 | 0 | |a NICOTINE |
| 690 | 1 | 0 | |a RUTHENIUM |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a COMPLEX FORMATION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYCLIC POTENTIOMETRY |
| 690 | 1 | 0 | |a IRRADIATION |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a LEECH |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY |
| 690 | 1 | 0 | |a PHOTOLYSIS |
| 690 | 1 | 0 | |a QUANTUM YIELD |
| 690 | 1 | 0 | |a SYNTHESIS |
| 690 | 1 | 0 | |a ULTRAVIOLET SPECTROSCOPY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ELECTROPHYSIOLOGY |
| 690 | 1 | 0 | |a LEECHES |
| 690 | 1 | 0 | |a LIGHT |
| 690 | 1 | 0 | |a MAGNETIC RESONANCE SPECTROSCOPY |
| 690 | 1 | 0 | |a MODELS, CHEMICAL |
| 690 | 1 | 0 | |a NEURONS |
| 690 | 1 | 0 | |a NICOTINE |
| 690 | 1 | 0 | |a PHOTOCHEMISTRY |
| 690 | 1 | 0 | |a PHOTOLYSIS |
| 690 | 1 | 0 | |a RUTHENIUM |
| 690 | 1 | 0 | |a HIRUDINIDA |
| 700 | 1 | |a Salierno, M. | |
| 700 | 1 | |a Etchenique, R. | |
| 773 | 0 | |d 2010 |g v. 104 |h pp. 1248-1251 |k n. 12 |p J. Inorg. Biochem. |x 01620134 |w (AR-BaUEN)CENRE-818 |t Journal of Inorganic Biochemistry | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jinorgbio.2010.08.003 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01620134_v104_n12_p1248_Filevich |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v104_n12_p1248_Filevich |y Registro en la Biblioteca Digital |
| 961 | |a paper_01620134_v104_n12_p1248_Filevich |b paper |c PE | ||
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| 999 | |c 68401 | ||