Antiviral activity of a carrageenan from Gigartina skottsbergii against intraperitoneal murine herpes simplex virus infection
The partially cyclized μ/v-carrageenan 1C3, isolated from the red seaweed Gigartina skottsbergii, was previously shown to be a potent inhibitor of the in vitro replication of Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Here the protective effect of 1C3 in a murine model of intraperitoneal (i...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2006
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 11479caa a22012977a 4500 | ||
|---|---|---|---|
| 001 | PAPER-7323 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203704.0 | ||
| 008 | 190411s2006 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33644542115 | |
| 024 | 7 | |2 cas |a carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; Antiviral Agents; Carrageenan, 9000-07-1; Plant Preparations | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PLMEA | ||
| 100 | 1 | |a Pujol, C.A. | |
| 245 | 1 | 0 | |a Antiviral activity of a carrageenan from Gigartina skottsbergii against intraperitoneal murine herpes simplex virus infection |
| 260 | |c 2006 | ||
| 270 | 1 | 0 | |m Pujol, C.A.; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428BGA Buenos Aires, Argentina; email: capujol@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Witvrouw, M., De Clercq, E., Sulfated polysaccharides extracted from sea algae as potential antiviral drugs (1997) Gen Pharmacol, 29, pp. 497-511 | ||
| 504 | |a Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Sulfated seaweed polysaccharides as antiviral agents (2004) Curr Med Chem, 11, pp. 2399-2419 | ||
| 504 | |a Lüscher-Mattli, M., Polyanions - A lost chance in the fight against HIV and other virus diseases? (2000) Antiviral Chem Chemother, 11, pp. 249-259 | ||
| 504 | |a Weiler, B.E., Schroder, H.C., Stefanovich, V., Stewart, D., Forrest, J.M.S., Allen, L.B., Sulphoevernan, a polyanionic polysaccharide, and the narcissus lectin potently inhibit human immunodeficiency virus infection by binding to viral envelope protein (1990) J Gen Virol, 71, pp. 1957-1963 | ||
| 504 | |a Furusawa, E., Furusawa, S., Chou, S.C., Antileukemic activity of Viva-Natural, a dietary seaweed extract, on Rauscher murine leukemia in comparison with anti-HIV agents, azidothymidine, dextran sulfate and pentosan polysulfate (1991) Cancer Lett, 56, pp. 197-220 | ||
| 504 | |a Diringer, H., Ehlers, B., Chemoprophylaxis of scrapie in mice (1991) J Gen Virol, 172, pp. 457-460 | ||
| 504 | |a Hamasuna, R., Eizuru, Y., Shishime, Y., Minamishima, Y., Protective effect of carrageenan against murine cytomegalovirus infection in mice (1993) Antiviral Chem Chemother, 4, pp. 353-360 | ||
| 504 | |a Pancheva, S.N., Antiherpes effect of dextran sulphate combined with acyclovir in vitro and in vivo (1993) Antiviral Chem Chemother, 4, pp. 189-191 | ||
| 504 | |a Mathes, L.E., Hayes, K.A., Swenson, C.L., Polas, P.J., Weisbrode, S.E., Kociba, G.J., Evaluation of antiviral activity and toxicity of dextran sulfate in feline leukemia virus-infected cats (1991) Antimicrob Agents Chemother, 35, pp. 2147-2150 | ||
| 504 | |a Offensperger, W.B., Offensperger, S., Walter, E., Blum, H.E., Gerok, W., Sulfated polyanions do not inhibit duck hepatitis B virus infection (1991) Antimicrob Agents Chemother, 35, pp. 2431-2433 | ||
| 504 | |a Zacharopoulos, V.R., Phillips, D.M., Vaginal formulations of carrageenan protect mice from Herpes simplex virus infection (1997) Clin Diagn Lab Immunol, 4, pp. 465-468 | ||
| 504 | |a Bourne, K.Z., Bourne, N., Reising, S.F., Stanberry, L.R., Plant products as topical microbicide candidates: Assessment of in vitro and in vivo activity against herpes simplex virus type 2 (1999) Antiviral Res, 42, pp. 219-226 | ||
| 504 | |a Coggins, C., Blanchard, K., Alvarez, B., Brache, V., Weisberg, E., Kilmarx, P.H., Preliminary safety and acceptability of a carrageenan gel for possible use as a vaginal microbicide (2000) Sex Trans Infect, 76, pp. 480-483 | ||
| 504 | |a Carlucci, M.J., Scolaro, L.A., Noseda, M.D., Cerezo, A.S., Damonte, E.B., Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice (2004) Antiviral Res, 64, pp. 137-141 | ||
| 504 | |a Carlucci, M.J., Pujol, C.A., Ciancia, M., Noseda, M.D., Matulewicz, M.C., Damonte, E.B., Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives: Correlation between structure and biological activity (1997) Int J Biol Macromol, 20, pp. 97-105 | ||
| 504 | |a Carlucci, M.J., Scolaro, L.A., Damonte, E.B., Inhibitory action of natural carrageenans on Herpes simplex virus infection of mouse astrocytes (1999) Chemotherapy, 45, pp. 429-436 | ||
| 504 | |a Carlucci, M.J., Ciancia, M., Matulewicz, M.C., Cerezo, A.S., Damonte, E.B., Antiherpetic activity and mode of action of natural carrageenans of diverse structural types (1999) Antiviral Res, 43, pp. 93-102 | ||
| 504 | |a Tal-Singer, R., Peng, C., Ponce De Leon, M., Abrams, W.R., Banfield, B.W., Tufaro, F., Interaction of Herpes simplex virus glycoprotein gC with mammalian cell surface molecules (1995) J Virol, 69, pp. 4471-4483 | ||
| 504 | |a Matulewicz, M.C., Ciancia, M., Noseda, M.D., Cerezo, A.S., Carrageenan systems from tetrasporic and cystocarpic stages of Gigartina skottsbergii (1989) Phytochemistry, 28, pp. 2937-2941 | ||
| 504 | |a Ciancia, M., Matulewicz, M.C., Finch, P., Cerezo, A.S., Determination of the structures of cystocarpic carrageenans from Gigartina skottsbergii by methylation analysis and NMR spectroscopy (1993) Carbohydr Res, 238, pp. 241-248 | ||
| 504 | |a Couto, A.S., Gonçalves, M.F., Colli, W., De Lederkremer, R.M., The N-linked carbohydrate chain of the 85-kilodalton glycoprotein from Trypanosoma cruzi trypomastigotes contains sialyl, fucosyl and galactosyl(α-1-3)galactose units (1990) Mol Biochem Parasitol, 39, pp. 101-108 | ||
| 504 | |a Hartman, N.R., Johns, D.G., Mitsuya, H., Pharmacokinetic analysis of dextran sulfate in rats as pertains to its clinical usefulness for therapy of HIV infection (1990) AIDS Res Hum Retroviruses, 6, pp. 805-812 | ||
| 504 | |a Hayashi, K., Hayashi, T., Kojima, I., A natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: In vitro and ex vivo evaluation of anti-Herpes simplex virus and anti-human immunodeficiency virus activities (1996) AIDS Res Hum Retroviruses, 12, pp. 1463-1471 | ||
| 504 | |a Nakashima, H., Yoshida, O., Baba, M., De Clercq, E., Yamamoto, N., Anti-HIV activity of dextran sulphate as determined under different experimental conditions (1989) Antiviral Res, 11, pp. 233-246 | ||
| 504 | |a Guimaraes, M.A.M., Mourao, P.A.S., Urinary excretion of sulfated polysaccharides administered to Wistar rats suggest a renal permselectivity to these polymers based on molecular size (1997) Biochim Biophys Acta, 1335, pp. 161-172 | ||
| 504 | |a Ni, L., Boudinot, F.D., Boudinot, S.G., Henson, G.W., Bossard, G.E., Martellucci, S.A., Pharmacokinetics of antiviral polyoxometalates in rats (1994) Antimicrob Agents Chemother, 38, pp. 504-510 | ||
| 520 | 3 | |a The partially cyclized μ/v-carrageenan 1C3, isolated from the red seaweed Gigartina skottsbergii, was previously shown to be a potent inhibitor of the in vitro replication of Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Here the protective effect of 1C3 in a murine model of intraperitoneal (i.p.) HSV-1 infection was evaluated. OF1 mice were i.p. infected with 5 × 105 PFU of HSV-1 KOS strain, and the effects of different treatments with 1C3 were studied. When 30 mg/kg of body weight of 1C3 was administered by the i.p. route immediately after HSV-1 infection, 87.5% survival of the animals was achieved (p < 0.005), associated with a delay in the mean day of death in 1C3-treated non-surviving mice. Animal survival was not improved when multiple doses of 1C3 were also given in the period 1-48 h post-infection, and no protection was afforded when treatment was started after 24 h of infection. When virus and compound were injected by different routes, i.p. and intravenous (i.v.), respectively, a still significant protection was achieved (40% survival, p < 0.05). No toxicity of 1C3 for the animals was recorded. The pharmacokinetic properties were analyzed after injection of 1C3 into the tail vein by monitoring of [3H]-1C3 in plasma and organs and by a bioassay of the anti-HSV-1 activity remaining in serum after non-radioactive 1C3 inoculation. A very rapid disappearance of the compound from the blood was observed since only 5.9-0.9% of the radioactivity of the initially administered [3H]-1C3 appeared in the plasma between 5-300 minutes after administration. A transient peak of radioactivity was detected in the kidney 15 minutes after inoculation. The bioassay confirms the presence of the compound circulating in a biologically active form up to 1 hour after injection. © Georg Thieme Verlag KG Stuttgart. |l eng | |
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428BGA Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTIVIRAL AGENT |
| 690 | 1 | 0 | |a GIGARTINA SKOTTSBERGII |
| 690 | 1 | 0 | |a GIGARTINACEAE |
| 690 | 1 | 0 | |a GIGARTINALES |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS |
| 690 | 1 | 0 | |a MOUSE INTRAPERITONEAL INFECTION |
| 690 | 1 | 0 | |a NATURAL CARRAGEENAN |
| 690 | 1 | 0 | |a PHARMACOKINETICS |
| 690 | 1 | 0 | |a CARRAGEENAN |
| 690 | 1 | 0 | |a GIGARTINA SKOTTSBERGII EXTRACT |
| 690 | 1 | 0 | |a PLANT EXTRACT |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANTIVIRAL ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DRUG BIOAVAILABILITY |
| 690 | 1 | 0 | |a DRUG BLOOD LEVEL |
| 690 | 1 | 0 | |a DRUG HALF LIFE |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a HERPES SIMPLEX |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS 1 |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS 2 |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a SURVIVAL |
| 690 | 1 | 0 | |a ALGAE, RED |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a CARRAGEENAN |
| 690 | 1 | 0 | |a DISEASE MODELS, ANIMAL |
| 690 | 1 | 0 | |a HERPES SIMPLEX |
| 690 | 1 | 0 | |a INJECTIONS, INTRAPERITONEAL |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a PHYTOTHERAPY |
| 690 | 1 | 0 | |a PLANT PREPARATIONS |
| 690 | 1 | 0 | |a TISSUE DISTRIBUTION |
| 690 | 1 | 0 | |a ALGAE |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a GIGARTINA SKOTTSBERGII |
| 690 | 1 | 0 | |a GIGARTINACEAE |
| 690 | 1 | 0 | |a GIGARTINALES |
| 690 | 1 | 0 | |a HERPES |
| 690 | 1 | 0 | |a HUMAN HERPESVIRUS 1 |
| 690 | 1 | 0 | |a HUMAN HERPESVIRUS 2 |
| 690 | 1 | 0 | |a MURINAE |
| 690 | 1 | 0 | |a SIMPLEXVIRUS |
| 700 | 1 | |a Scolaro, L.A. | |
| 700 | 1 | |a Ciancia, M. | |
| 700 | 1 | |a Matulewicz, M.C. | |
| 700 | 1 | |a Cerezo, A.S. | |
| 700 | 1 | |a Damonte, E.B. | |
| 773 | 0 | |d 2006 |g v. 72 |h pp. 121-125 |k n. 2 |p Planta Med. |x 00320943 |t Planta Medica | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644542115&doi=10.1055%2fs-2005-373168&partnerID=40&md5=ab0028f8cce928cf1ba4406c18e8d641 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1055/s-2005-373168 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00320943_v72_n2_p121_Pujol |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v72_n2_p121_Pujol |y Registro en la Biblioteca Digital |
| 961 | |a paper_00320943_v72_n2_p121_Pujol |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 68276 | ||